Conjugated linoleic acid: implications for human health.

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression by targeting specific mRNAs for degradation or translation repression. Changes in miRNAs expression profiles have been reported in several neurodegenerative disorders such as Alzheimer's disease (AD) and related tauopathies...

journal_title：Pharmacological research

authors： Bazrgar M,Khodabakhsh P,Mohagheghi F,Prudencio M,Ahmadiani A

更新日期：2020-05-01 00:00:00

abstract：:Endothelial dysfunction (ED), an established response to cardiovascular risk factors, is characterized by increased levels of soluble molecules secreted by endothelial cells (EC). Evidence suggest that ED is an independent predictor of cardiac events and that it is associated with a deficiency in production or bioavai...

journal_title：Pharmacological research

authors： Charles S,Raj V,Arokiaraj J,Mala K

更新日期：2017-05-01 00:00:00

abstract：:Gamma-vinyl GABA (vigabatrin; VGB), an irreversible inhibitor of GABA-transaminase, was evaluated for its effect on the contractile responses to PGE(2) or its precursor arachidonic acid (AA) in guinea pig ileum (GPI) and non-pregnant rat uterus. Rationale behind this study was the rise in gamma-aminobutyric acid (GABA...

journal_title：Pharmacological research

authors： Raza M,Al-Shabanah OA

更新日期：2003-06-01 00:00:00

abstract：:The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...

journal_title：Pharmacological research

authors： Turan NN,Demiryürek AT,Kanzik I

更新日期：2000-05-01 00:00:00

abstract：:We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta...

journal_title：Pharmacological research

authors： Dinca M,Serban MC,Sahebkar A,Mikhailidis DP,Toth PP,Martin SS,Blaha MJ,Blüher M,Gurban C,Penson P,Michos ED,Hernandez AV,Jones SR,Banach M,for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

更新日期：2016-05-01 00:00:00

abstract：:The potential drug-to-drug interaction between darunavir and raltegravir in the setting of HIV infection is a highly debated issue still unresolved. In the present study we have evaluated the pharmacokinetics of darunavir and ritonavir in 53 HIV-1 infected patients with or without concomitant raltegravir administratio...

journal_title：Pharmacological research

authors： Cattaneo D,Gervasoni C,Cozzi V,Baldelli S,Fucile S,Meraviglia P,Landonio S,Boreggio G,Rizzardini G,Clementi E

更新日期：2012-02-01 00:00:00

abstract：:Novel therapeutic strategies are needed to address and to solve the emerging problem of hypoxia-induced resistance to anticancer drugs. N-(4-Hydroxyphenyl)retinamide (4-HPR) exhibits potent anticancer and chemopreventive activities, but its inefficiency under hypoxia, through undetermined mechanisms, may contribute to...

journal_title：Pharmacological research

authors： Liu XW,Su Y,Zhu H,Cao J,Ding WJ,Zhao YC,He QJ,Yang B

更新日期：2010-11-01 00:00:00

abstract：:Iron is an essential element for virtually all organisms. It facilitates cell proliferation and growth but also contributes to major hallmarks of cancer such as tumor initiation, growth, and metastasis. Often, iron handling of tumor cells is disturbed, with altered iron acquisition, efflux, and storage. Targeting pert...

journal_title：Pharmacological research

authors： Jung M,Mertens C,Bauer R,Rehwald C,Brüne B

更新日期：2017-06-01 00:00:00

abstract：:Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

journal_title：Pharmacological research

authors： Chiarugi A

更新日期：2005-07-01 00:00:00

abstract：:A global transcriptional regulator, MgrA, was previously identified as a key determinant of virulence in Staphylococcus aureus. An 80% EtOH extract of Uncaria gambier was found to attenuate the virulence of S. aureus via its effects on MgrA. Using bioassay-guided fractionation, a polyphenolic polymer, uncariitannin, w...

journal_title：Pharmacological research

authors： Zhang H,Jiang JM,Han L,Lao YZ,Zheng D,Chen YY,Wan SJ,Zheng CW,Tan HS,Li ZG,Xu HX

更新日期：2019-09-01 00:00:00

abstract：:This article summarizes the discovery and the development of endothelial biology with a special focus on the role of endothelium-dependent vasoconstriction. The physician-scientist Paul Michel Vanhoutte contributed many of the initial observations that helped to understand and form the main concepts of modern vascular...

journal_title：Pharmacological research

authors： Barton M

更新日期：2011-06-01 00:00:00

abstract：:Nebivolol is a new selective beta 1-adrenergic blocking agent, that possesses a peculiar pharmacodynamic profile and an original chemical structure, by which it differs from traditional beta 1-blockers. Nebivolol is a racemic mixture of two enantiomers in equal ratios. It is endowed with a highly selective beta 1-bloc...

journal_title：Pharmacological research

authors： Mangrella M,Rossi F,Fici F,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

journal_title：Pharmacological research

authors： Epstein AN

更新日期：1992-02-01 00:00:00

abstract：:Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...

journal_title：Pharmacological research

authors： Mansour MA,El-Kashef HA,Al-Shabanah OA

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...

journal_title：Pharmacological research

authors： Korolkiewicz RP,Tashima K,Fujita A,Kato S,Takeuchi K

更新日期：2000-02-01 00:00:00

abstract：:Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolit...

journal_title：Pharmacological research

authors： Chow HH,Hakim IA

更新日期：2011-08-01 00:00:00

abstract：:Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1997-12-01 00:00:00

abstract：:Cardiovascular baroreflex mechanisms and sympathetic tone could be involved in the arterial hypertension by coarctation of abdominal aorta artery (CoA). The present work analyzes the effect on the arterial pressure and heart rate (HR) of the clonidine, an alpha(2)-adrenergic central acting antihypertensive agent, afte...

journal_title：Pharmacological research

authors： Gorzalczany SB,Opezzo JA,del Carmen Garcia M,Taira CA

更新日期：2003-07-01 00:00:00

abstract：:The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...

journal_title：Pharmacological research

authors： Arzi A,Hemmati AA,Razian A

更新日期：2004-03-01 00:00:00

abstract：:The antipsychotic drug olanzapine is widely used in the treatment of schizophrenia, bipolar and other mental disorders; however, it causes serious metabolic disorders, including dyslipidemia. Our previous studies have identified that olanzapine activated expression of the sterol regulatory element binding transcriptio...

journal_title：Pharmacological research

authors： Su Y,Liu X,Lian J,Deng C

更新日期：2020-05-01 00:00:00

abstract：:In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sen...

journal_title：Pharmacological research

authors： Kounenis G,Koutsoviti-Papadopoulou M,Elezoglou V

更新日期：1995-06-01 00:00:00

abstract：:Male Swiss Webster mice exhibited antinociception, hypothermia and Straub tail 3h following a 75mg morphine pellet implantation. These signs disappeared by 72h, and the morphine-pelleted mice were indistinguishable from placebo-pelleted ones, although brain morphine concentrations ranged from 200 to 400ng/gm. We previ...

journal_title：Pharmacological research

authors： Smith FL,Javed RR,Smith PA,Dewey WL,Gabra BH

更新日期：2006-12-01 00:00:00

abstract：:Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack...

journal_title：Pharmacological research

authors： Wu T,Yu GY,Xiao J,Yan C,Kurihara H,Li YF,So KF,He RR

更新日期：2018-07-01 00:00:00

abstract：:The concept of compartment evolved in the contexts of radioactivity, physiology, pharmacology and tracer kinetics. Recently compartmental models have been compared with 'physiological models', even though in most cases the same, or stricter hypotheses, are necessary for the validity of these latter models. This paper ...

journal_title：Pharmacological research

authors： Rescigno A

更新日期：2001-10-01 00:00:00

abstract：:Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Foll...

journal_title：Pharmacological research

authors： Panini R,Vandelli MA,Forni F,Pradelli JM,Salvioli G

更新日期：1995-03-01 00:00:00

abstract：:Vascular responses to hypoxia are heterogeneous and involve the release of vasodilators substances such as nitric oxide (NO) and prostacyclin (PGI(2)). In vitro studies have shown that Vitamin K(1) modulates the release of arachidonic acid (AA) in vascular cells, and thus inhibits the capacity of blood vessels to synt...

journal_title：Pharmacological research

authors： Tirapelli CR,Mingatto FE,De Godoy MA,Ferreira R,De Oliviera AM

更新日期：2002-12-01 00:00:00

abstract：:The EEG and behavioural changes induced by the administration of polyamines (spermine and spermidine) were studied in rabbit. Spermine and spermidine were administered at different doses (200 and 400 micrograms) into the mesencephalic ventricle (i.c.v.) both as a bolus and in constant perfusion (60 min duration). We a...

journal_title：Pharmacological research

authors： Bo P,Giorgetti A,Camana C,Savoldi F

更新日期：1990-07-01 00:00:00

abstract：:The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization (WHO), and its harm degree is defined as a global "pandemic". At present, the efforts of various countries focus on the rapid di...

journal_title：Pharmacological research

authors： Huang F,Li Y,Leung EL,Liu X,Liu K,Wang Q,Lan Y,Li X,Yu H,Cui L,Luo H,Luo L

更新日期：2020-08-01 00:00:00

abstract：:It is generally accepted that divalent cations are involved in the nociceptive pathway. The effect of systemic co-administration of magnesium sulfate and calcium channel blockers (nifedipine, verapamil) on the analgesic effect of opioid (mixed mu/kappa: butorphanol) and non-opioid drugs (paracetamol) was investigated....

journal_title：Pharmacological research

authors： Assi AA

更新日期：2001-06-01 00:00:00

abstract：:Mild cognitive impairment (MCI), regarded as the prodromal stage before the clinical phase of Alzheimer's disease (AD), has been considered for early intervention. Unfortunately, many trials in this stage with drugs with single-target turned out to be little or no effect. Multi-targeting in nature based on the theory ...

journal_title：Pharmacological research

authors： Zhang J,Yang C,Wei D,Li H,Leung EL,Deng Q,Liu Z,Fan XX,Zhang Z

更新日期：2019-08-01 00:00:00