Effect of nimodipine on systemic, renal, and cerebral haemodynamics after a mild hypoxic-ischaemic insult in newborn piglets.


:Because many Ca2+ channel blocking agents are known to cause adverse systemic effects, in this study we tested the haemodynamic side effects of nimodipine with and without a mild hypoxic-ischaemic (HI) insult in a newborn piglet model. Fifteen min after completing a brief period of asphyxia we gave i.v. nimodipine as 5 micrograms kg-1 bolus followed by 0.1 microgram kg-1 min-1 continuous infusion for 105 min in six piglets, while the same treatment was repeated in five animals without preceding HI insult. At third group of six served as sham operated controls. In the HI insult group by 105 min of nimodipine infusion the mean BP dropped by 30% and the cardiac output dropped by 23% of respective baseline. In this group, the renal blood flow dropped between 65% and 77% of baseline and regional cerebral blood flow dropped between 28% and 55% of respective baseline by 45 min and 105 min of nimodipine fashion. In the group with no prior HI insult, 105 min of nimodipine infusion caused no significant changes in these variables. Despite nimodipine infusion, HI insult caused a significant increase in the mean brain water content compared to the two control groups: 89 +/- 3.2% compared to 82.7 +/- 0.5% in the nimodipine control group, and 83.7 +/- 1.7% in the sham group (P < 0.0001). We conclude that while nimodipine therapy without prior asphyxial insult does not cause significant adverse haemodynamic effects, its infusion after even a mild HI insult could cause reduction in renal blood flow and moderate reduction in regional cerebral blood flow, BP, and cardiac output, suggesting a differential effect. A 15 min lag between HI insult and nimodipine therapy may be too long to prevent cerebral oedema.


Pharmacol Res


Pharmacological research


Raju TN,John E,Shankararao R,Fornell L,Vasa R,Abu-Harb M




Has Abstract


1996-01-01 00:00:00














  • Advances into Understanding the Vital Role of the Mitochondrial Citrate Carrier (CIC) in Metabolic Diseases.

    abstract::The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found i...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Peng R,Zhang M,Wang H,Lin J,Wang H,Wang F,Liu L,Zhao Q,Liu J

    更新日期:2020-11-01 00:00:00

  • Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives.

    abstract::Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gambardella A,Labate A,Cifelli P,Ruffolo G,Mumoli L,Aronica E,Palma E

    更新日期:2016-11-01 00:00:00

  • Prenatal metformin exposure or organic cation transporter 3 knock-out curbs social interaction preference in male mice.

    abstract::Poorly managed gestational diabetes can lead to severe complications for mother and child including fetal overgrowth, neonatal hypoglycemia and increased autism risk. Use of metformin to control it is relatively new and promising. Yet safety concerns regarding gestational metformin use remain, as its long-term effects...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Garbarino VR,Santos TA,Nelson AR,Zhang WQ,Smolik CM,Javors MA,Daws LC,Gould GG

    更新日期:2019-02-01 00:00:00

  • Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease.

    abstract::Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide that afflicts human health. With the in-depth study of the disease, its pathogenesis has gradually become clear. Although great breakthroughs have been made in the research of ALD, the research and development of drugs related to ALD has...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Hu S,Li SW,Yan Q,Hu XP,Li LY,Zhou H,Pan LX,Li J,Shen CP,Xu T

    更新日期:2019-12-01 00:00:00

  • Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats.

    abstract::Lipid peroxidation increased both in the liver homogenates and in the hepatic mitochondrial fraction of bile duct ligated (BDL)-rats. Although mitochondrial superoxide dismutase (SOD) activity did not change in the liver, glutathione (GSH) levels and glutathione peroxidase (GSH-Px) activity decreased in hepatic mitoch...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Alptekin N,Mehmetçik G,Uysal M,Aykaç-toker G

    更新日期:1997-09-01 00:00:00

  • Ultramicronized palmitoylethanolamide (PEA-um(®)) in the treatment of idiopathic pulmonary fibrosis.

    abstract::Pulmonary fibrosis is a chronic condition characterized by progressive scarring of lung parenchyma. The aim of this study was to examine the effects of an ultramicronized preparation of palmitoylethanolamide (PEA-um(®)), an endogenous fatty acid amide, in mice subjected to idiopathic pulmonary fibrosis. Idiopathic pul...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Di Paola R,Impellizzeri D,Fusco R,Cordaro M,Siracusa R,Crupi R,Esposito E,Cuzzocrea S

    更新日期:2016-09-01 00:00:00

  • The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone.

    abstract::The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

    更新日期:1993-02-01 00:00:00

  • Statins in chronic kidney disease and kidney transplantation.

    abstract::HMG-CoA reductase inhibitors (statins) have been shown to improve cardiovascular (CV) outcomes in the general population as well as in patients with cardiovascular disease (CVD). Statins' beneficial effects have been attributed to both cholesterol-lowering and cholesterol-independent "pleiotropic" properties. By their...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kassimatis TI,Goldsmith DJ

    更新日期:2014-10-01 00:00:00

  • Relationship between constitutive nitric oxide synthase activity and mucus level in the gastric mucosa of rats with stress.

    abstract::A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Nishida K,Ohta Y,Ishiguro I

    更新日期:1998-11-01 00:00:00

  • Targeting nanoparticles to cancer.

    abstract::Nanotechnology applications in medicine, termed as nanomedicine, have introduced a number of nanoparticles of variable chemistry and architecture for cancer imaging and treatment. Nanotechnology involves engineering multifunctional devices with dimensions at the nanoscale, similar dimensions as those of large biologic...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Wang M,Thanou M

    更新日期:2010-08-01 00:00:00

  • The potentiation of the histamine release induced by adenosine in mast cells from guinea pig lung and heart: sharp dependence on the time of preincubation.

    abstract::We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Campos BG,Ferreira RR,Gomes JC

    更新日期:2000-03-01 00:00:00

  • Effect of captopril on doxorubicin-induced nephrotoxicity in normal rats.

    abstract::Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mansour MA,El-Kashef HA,Al-Shabanah OA

    更新日期:1999-03-01 00:00:00

  • Impact of SLC22A1 and CYP3A5 genotypes on imatinib response in chronic myeloid leukemia: A systematic review and meta-analysis.

    abstract::Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia (CML). In the present study, we conducted a systematic review and meta-analysis of published studies to estimate the impac...

    journal_title:Pharmacological research

    pub_type: 杂志文章,meta分析


    authors: Cargnin S,Ravegnini G,Soverini S,Angelini S,Terrazzino S

    更新日期:2018-05-01 00:00:00

  • Vasoactive eicosanoids in the rat heart: clues to a contributory role of cardiac thromboxane to post-ischaemic hyperaemia.

    abstract::To assess the potential role of vasoactive cardiac eicosanoids in the modulation of coronary flow, we measure thromboxane(TX)B2, 6-keto-prostaglandin(PG)F1 alpha, PGE2 and sulphido-peptide leukotrienes (LTC4, D4, E4) in the coronary effluent of isolated perfused rat heart in both baseline and post-ischaemic conditions...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Giannessi D,Lazzerini G,Sicari R,DeCaterina R

    更新日期:1992-12-01 00:00:00

  • Candidate drugs against SARS-CoV-2 and COVID-19.

    abstract::Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infect...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: McKee DL,Sternberg A,Stange U,Laufer S,Naujokat C

    更新日期:2020-07-01 00:00:00


    abstract::Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patient...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ahaneku JE,Sakata K,Urano T,Takada Y,Takada A

    更新日期:2000-01-01 00:00:00

  • Effects of heparin-binding protein (CAP37/azurocidin) in a porcine model of Actinobacillus pleuropneumoniae-induced pneumonia.

    abstract::Heparin-binding protein (HBP; CAP37/azurocidin) is secreted from neutrophil leukocytes early during inflammation and plays a central role in early capillary leakage and extravasation of neutrophils. Furthermore, HBP is chemotactic towards monocytes and lymphocytes and protects against stress-induced apoptosis, e.g. in...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

    更新日期:2005-06-01 00:00:00

  • Dopaminergic projection to the septum mediates facilitatory effect of angiotensins on recognition memory in rats.

    abstract::We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition me...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Winnicka MM,Braszko JJ,Wiśniewski K

    更新日期:1997-11-01 00:00:00

  • Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice.

    abstract::We compared the protective abilities of Mangifera indica L. stem bark extract (Vimang) 50-250 mgkg(-1), mangiferin 50 mgkg(-1), vitamin C 100 mgkg(-1), vitamin E 100 mgkg(-1)and beta -carotene 50 mgkg(-1)against the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced oxidative damage in serum, liver, brain as well as i...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sánchez GM,Re L,Giuliani A,Núñez-Sellés AJ,Davison GP,León-Fernández OS

    更新日期:2000-12-01 00:00:00

  • Diabetes differentially modulated receptor- and non-receptor-mediated relaxation in rat renal artery.

    abstract::In this study, we have investigated the vasodilator response to acetylcholine under diabetic conditions in isolated renal arteries of Wistar rats. The effect of nitric oxide synthase (NOS) inhibition on acetylcholine-induced vasodilator response was investigated. We have also examined the effects of two endothelium-de...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yousif MH

    更新日期:2003-09-01 00:00:00

  • Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats.

    abstract::The natural resin collected from the trunk wood of Protium heptaphyllum is used in folk medicine to treat inflammatory conditions and to hasten wound repair. In the search of new potential anti-inflammatory agents with gastroprotective property, the present study evaluated its effects in experimental models of gastric...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Oliveira FA,Vieira-Júnior GM,Chaves MH,Almeida FR,Florêncio MG,Lima RC Jr,Silva RM,Santos FA,Rao VS

    更新日期:2004-02-01 00:00:00

  • Selective angiotensin II type 1 receptor blockade ameliorates cyclosporine nephrotoxicity.

    abstract::Nephrotoxicity associated with cyclosporine A (CsA) administration is characterized by marked renal vasoconstriction, interstitial fibrosis and arteriolar hypertrophy. The molecular mechanisms of CsA nephrotoxicity are not well characterized, but previous studies have demonstrated that angiotensin II (Ang II), the pri...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Padi SS,Chopra K

    更新日期:2002-05-01 00:00:00

  • Newer agents for coronary thrombolysis. Perspectives from clinical studies.

    abstract::Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

    更新日期:1989-03-01 00:00:00

  • An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines.

    abstract::Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety of cancer cell lines. The objective of this study was to determine the inhibitory effects of gossypol on cell proliferation. Five human carcinoma cell lines were evaluated including endometrial (RL95-2), ovarian (SKOV-3), me...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Le Blanc M,Russo J,Kudelka AP,Smith JA

    更新日期:2002-12-01 00:00:00

  • Inhibition of the NANC relaxation of the guinea-pig proximal colon longitudinal muscle by the purinoceptor antagonist PPADS, inhibition of nitric oxide synthase, but not by a PACAP/VIP antagonist.

    abstract::The effects of the P(2)-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl- 2('),4(')- disulphonic acid (PPADS), the nitric oxide (NO) synthase inhibitor N(G)-nitro- l -arginine (l -NOARG), the K(+)-channel blocker apamin, the pituitary adenylate cyclase activating peptide (PACAP) antagonist PACAP(6-38) and the s...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Rózsai B,Lázár Z,Benkó R,Barthó L

    更新日期:2001-01-01 00:00:00

  • Allosteric MEK1/2 inhibitors including cobimetanib and trametinib in the treatment of cutaneous melanomas.

    abstract::The Ras-Raf-MEK-ERK (Map kinase) cellular pathway is a highly conserved eukaryotic signaling module that transduces extracellular signals from growth factors and cytokines into intracellular regulatory events that are involved in cell growth and proliferation or the contrary pathway of cell differentiation. Dysregulat...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Roskoski R Jr

    更新日期:2017-03-01 00:00:00

  • Improvement of ursodeoxycholic acid bioavailability by 2-hydroxypropyl-beta-cyclodextrin complexation in healthy volunteers.

    abstract::Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Foll...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panini R,Vandelli MA,Forni F,Pradelli JM,Salvioli G

    更新日期:1995-03-01 00:00:00

  • From stroke to neurodegenerative diseases: The multi-target neuroprotective effects of 3-n-butylphthalide and its derivatives.

    abstract::Discovering effective agents to slow or stop neurodegeneration is a challenging task. Over decades, only a few drugs were approved by Food and Drug Administration (FDA) and most ended in failure. The lessons learned have switched the strategy of drug discovery from designing highly selective ligands to a network pharm...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Huang L,Wang S,Ma F,Zhang Y,Peng Y,Xing C,Feng Y,Wang X,Peng Y

    更新日期:2018-09-01 00:00:00

  • L-histidine-mediated enhancement of hydrogen peroxide-induced cytotoxicity: relationships between DNA single/double strand breakage and cell killing.

    abstract::Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cantoni O,Guidarelli A,Sestili P,Giacomoni PU,Cattabeni F

    更新日期:1994-02-01 00:00:00

  • Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

    abstract::Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhu Y,Zhu C,Yang H,Deng J,Fan D

    更新日期:2020-05-01 00:00:00