Abstract:
:We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition memory. In this study, the influence of both angiotensins, given intracerebroventricularly at the dose of 1 nmol each, in rats lesioned with 6-OHDA to the nucleus accumbens septi (NAS) and to the nucleus septi lateralis (NSL) on recognition memory was evaluated. AII and its 3-7 fragment significantly improved object recognition in sham-operated to NAS and to NSL groups of rats. Bilateral 6-OHDA lesions to NAS totally abolished and to NSL significantly attenuated the facilitatory effect of both angiotensins on object recognition. These results suggest that the dopaminergic projection arriving to the septal structures. NAS and NSL takes part in the facilitatory effect of angiotensins on recognition memory.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Winnicka MM,Braszko JJ,Wiśniewski Kdoi
10.1006/phrs.1997.0257subject
Has Abstractpub_date
1997-11-01 00:00:00pages
387-94issue
5eissn
1043-6618issn
1096-1186pii
S1043-6618(97)90257-7journal_volume
36pub_type
杂志文章abstract::Breast cancer is a leading cause of morbidity and mortality in women. Both Epidemiological and experimental studies indicate a positive correlation between alcohol consumption and the risk of breast cancer. While alcohol exposure may promote the carcinogenesis or onset of breast cancer, it may as well enhance the prog...
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