Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells.

abstract：:Results presented in this study demonstrate an association between the L-Histidine-mediated enhancement of H2O2-induced cytotoxicity and the formation of DNA double strand breakage (DSB), whereas no relationship exists between the increased cytotoxic response and DNA single strand breakage (SSB). Indeed, the higher le...

journal_title：Pharmacological research

authors： Cantoni O,Guidarelli A,Sestili P,Giacomoni PU,Cattabeni F

更新日期：1994-02-01 00:00:00

abstract：:Ranolazine has characteristic properties of a selective inhibitor of the inward sodium current. It is primarily indicated as an anti-anginal agent in patients with coronary artery disease and chronic stable angina. Recently, ranolazine has been noted to possibly impart beneficial effects in various other cardiac condi...

journal_title：Pharmacological research

authors： Mihos CG,Krishna RK,Kherada N,Larrauri-Reyes M,Tolentino A,Santana O

更新日期：2016-01-01 00:00:00

abstract：:Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...

journal_title：Pharmacological research

authors： Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi B

更新日期：2015-10-01 00:00:00

abstract：:The effect of chloroquine and other antimalarial drugs on glutamate dehydrogenase activity was studied in liver and renal mitochondria as well as in kidney-cortex tubules of rabbit. In permeabilized mitochondria, with free access of substrates and drugs to glutamate dehydrogenase, 100 microns chloroquine decreased bot...

journal_title：Pharmacological research

authors： Jarzyna R,Lenarcik E,Bryła J

更新日期：1997-01-01 00:00:00

abstract：:Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of pulmonary function, rapidly leading to death. While its clinical role as an anticancer agent is limited, its use in experimental settings is...

journal_title：Pharmacological research

authors： Della Latta V,Cecchettini A,Del Ry S,Morales MA

更新日期：2015-07-01 00:00:00

abstract：:The endogenous gasotransmitter hydrogen sulphide (H2S) is an important regulator of the cardiovascular system, particularly of myocardial function. Moreover, H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury, and is considered an important mediator of "ischemic preconditioning...

journal_title：Pharmacological research

authors： Testai L,Marino A,Piano I,Brancaleone V,Tomita K,Di Cesare Mannelli L,Martelli A,Citi V,Breschi MC,Levi R,Gargini C,Bucci M,Cirino G,Ghelardini C,Calderone V

更新日期：2016-11-01 00:00:00

abstract：:Inflammation plays a key role in tumor promotion and development. Indeed, cyclooxygenase-2 (COX-2) expression is strongly associated with different types of cancer. An emerging class of compounds with significant anti-inflammatory properties is the hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (H2S-...

journal_title：Pharmacological research

authors： De Cicco P,Panza E,Ercolano G,Armogida C,Sessa G,Pirozzi G,Cirino G,Wallace JL,Ianaro A

更新日期：2016-12-01 00:00:00

abstract：:The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2) infection has been listed as a public health emergency of international concern by the World Health Organization (WHO), and its harm degree is defined as a global "pandemic". At present, the efforts of various countries focus on the rapid di...

journal_title：Pharmacological research

authors： Huang F,Li Y,Leung EL,Liu X,Liu K,Wang Q,Lan Y,Li X,Yu H,Cui L,Luo H,Luo L

更新日期：2020-08-01 00:00:00

abstract：:Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell ...

journal_title：Pharmacological research

authors： Westermeier F,Bustamante M,Pavez M,García L,Chiong M,Ocaranza MP,Lavandero S

更新日期：2015-11-01 00:00:00

abstract：:Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infect...

journal_title：Pharmacological research

authors： McKee DL,Sternberg A,Stange U,Laufer S,Naujokat C

更新日期：2020-07-01 00:00:00

abstract：:Vascular responses to hypoxia are heterogeneous and involve the release of vasodilators substances such as nitric oxide (NO) and prostacyclin (PGI(2)). In vitro studies have shown that Vitamin K(1) modulates the release of arachidonic acid (AA) in vascular cells, and thus inhibits the capacity of blood vessels to synt...

journal_title：Pharmacological research

authors： Tirapelli CR,Mingatto FE,De Godoy MA,Ferreira R,De Oliviera AM

更新日期：2002-12-01 00:00:00

abstract：:In previous studies we observed an enhanced anti-inflammatory activity of MPEG-SOD derivatives in acute inflammation in rat. To assess the activity in chronic inflammation we tested the compound with longer half-life (MPEG-SOD 18) in complete adjuvant arthritis in rat. According to the prophylactic schedule of treatme...

journal_title：Pharmacological research

authors： Conforti A,Caliceti P,Sartore L,Schiavon O,Veronese F,Velo GP

更新日期：1991-01-01 00:00:00

abstract：:The present study examines the effect of benzyl isothiocyanate (BITC) on uterine contraction in vitro. BITC (10-320 microM) caused irreversible, concentration-dependent inhibition of the spontaneous, prostaglandin F(2alpha) (PGF(2alpha)) and oxytocin-induced force of gravid and non-gravid rat uterine contractions in c...

journal_title：Pharmacological research

authors： Adebiyi A,Adaikan PG,Prasad RN

更新日期：2004-05-01 00:00:00

abstract：:Corticosteroids are shown to have deleterious effects on wound healing for various tissues. Arginine metabolism and nitric oxide (NO) synthesis play an important role in many aspects of inflammation and wound healing. The study was designed to evaluate the relationship of dexamethasone impaired healing of tracheal ana...

journal_title：Pharmacological research

authors： Talas DU,Nayci A,Polat G,Atis S,Comelekoglu U,Bagdatoglu OT,Bagdatoglu C

更新日期：2002-09-01 00:00:00

abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...

journal_title：Pharmacological research

authors： Faillie JL

更新日期：2017-04-01 00:00:00

abstract：:Herpesviruses encode transmembrane G protein-coupled receptors (GPCRs), which share structural homology to human chemokine receptors. These viral GPCRs include KSHV-encoded ORF74, EBV-encoded BILF1, and HCMV-encoded US28, UL33, UL78 and US27. Viral GPCRs hijack various signaling pathways and cellular networks, includi...

journal_title：Pharmacological research

authors： van Senten JR,Fan TS,Siderius M,Smit MJ

更新日期：2020-06-01 00:00:00

abstract：:Aminoglycosides are very effective antibiotics for the treatment of severe infections, but they rank among the most frequent causes of drug-induced nephrotoxicity. Thus, prevention of aminoglycoside nephrotoxicity is an unmet therapeutic objective. Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, has ...

journal_title：Pharmacological research

authors： Quirós Y,Blanco-Gozalo V,Sanchez-Gallego JI,López-Hernandez FJ,Ruiz J,Perez de Obanos MP,López-Novoa JM

更新日期：2016-05-01 00:00:00

abstract：:Thioredoxin is one of the most important cellular antioxidant systems known to date, and is responsible of maintaining the reduced state of the intracellular space. Trx-1 is a small cytosolic protein whose transcription is induced by stress. Therefore it is possible that this antioxidant plays a protective role agains...

journal_title：Pharmacological research

authors： D'Annunzio V,Perez V,Boveris A,Gelpi RJ,Poderoso JJ

更新日期：2016-07-01 00:00:00

abstract：:Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1997-12-01 00:00:00

abstract：:Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6....

journal_title：Pharmacological research

authors： Chae HJ,Kim SC,Chae SW,An NH,Kim HH,Lee ZH,Kim HR

更新日期：2001-03-01 00:00:00

abstract：:Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

journal_title：Pharmacological research

authors： Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

更新日期：2020-11-01 00:00:00

abstract：:A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer p...

journal_title：Pharmacological research

authors： Kim DH,Khan H,Ullah H,Hassan STS,Šmejkal K,Efferth T,Mahomoodally MF,Xu S,Habtemariam S,Filosa R,Lagoa R,Rengasamy KR

更新日期：2019-09-01 00:00:00

abstract：:This paper describes a new sensitive gas chromatographic method with electron capture detector to assay estazolam in human plasma, which has been developed and validated for pharmacokinetic purposes. The drug and the internal standard (triazolam) were extracted from plasma buffered at pH 9.0 into toluene and analysed ...

journal_title：Pharmacological research

authors： Dal Bo L,Verga F,Marzo A,La Commare P,De Vito ML

更新日期：1997-04-01 00:00:00

abstract：:Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10...

journal_title：Pharmacological research

authors： Balakumar P,Varatharajan R,Nyo YH,Renushia R,Raaginey D,Oh AN,Akhtar SS,Rupeshkumar M,Sundram K,Dhanaraj SA

更新日期：2014-12-01 00:00:00

abstract：:Male weanling Wistar rats were fed a 4% cholestyramine diet and used as a model to demonstrate that a reduction in serum low density lipoproteins stimulates de novo cholesterogenesis leading to DNA synthesis and cell proliferation. Feeding this diet resulted in a decrease in serum very low density lipoproteins and low...

journal_title：Pharmacological research

authors： Kazanecki ME,Melhem MF,Spichty KJ,Kelly RH,Rao KN

更新日期：1989-09-01 00:00:00

abstract：:Monoamine oxidases (MAO) are mitochondrial enzymes that catalyze the oxidation of monoamines in multiple tissues, including the brain. Elevated MAO activity has long been implicated in the etiology of depression, anxiety, and neurodegenerative disease, fuelling the search for inhibitors in the prevention and treatment...

journal_title：Pharmacological research

authors： Dreiseitel A,Korte G,Schreier P,Oehme A,Locher S,Domani M,Hajak G,Sand PG

更新日期：2009-05-01 00:00:00

abstract：:The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties ...

journal_title：Pharmacological research

authors： Perreault M,Maltais R,Kenmogne LC,Létourneau D,LeHoux JG,Gobeil S,Poirier D

更新日期：2018-02-01 00:00:00

abstract：:In recent clinical observation, the growth of endothelial tumors, such as hemangiomas of infancy, was repressed by the non-selective beta-adrenergic antagonist propranolol possibly through targeting of the vascular endothelial compartment. As human brain microvascular endothelial cells (HBMEC) play an essential role a...

journal_title：Pharmacological research

authors： Annabi B,Lachambre MP,Plouffe K,Moumdjian R,Béliveau R

更新日期：2009-11-01 00:00:00

abstract：:Epidemiological studies suggest that diets with a high intake of vegetables and fruits may reduce the incidence of degenerative disorders including Alzheimer's disease. Berries are some of the popular fruits consumed worldwide. They are considered to be rich in anthocyanin pigments, a group belonging to the flavonoids...

journal_title：Pharmacological research

authors： Ramirez MR,Izquierdo I,do Carmo Bassols Raseira M,Zuanazzi JA,Barros D,Henriques AT

更新日期：2005-12-01 00:00:00

abstract：:Osteoporosis caused by aging and menopause had become an emerging threat to human health. The reduction of osteoblast differentiation has been considered to be an essential cause of osteoporosis. Osteoblast differentiation could be regulated by LncRNAs, and increasing evidences have proved that LncRNAs may be adopted ...

journal_title：Pharmacological research

authors： Yin C,Tian Y,Yu Y,Li D,Miao Z,Su P,Zhao Y,Wang X,Pei J,Zhang K,Qian A

更新日期：2021-01-01 00:00:00