Candidate drugs against SARS-CoV-2 and COVID-19.


:Outbreak and pandemic of coronavirus SARS-CoV-2 in 2019/2020 will challenge global health for the future. Because a vaccine against the virus will not be available in the near future, we herein try to offer a pharmacological strategy to combat the virus. There exists a number of candidate drugs that may inhibit infection with and replication of SARS-CoV-2. Such drugs comprise inhibitors of TMPRSS2 serine protease and inhibitors of angiotensin-converting enzyme 2 (ACE2). Blockade of ACE2, the host cell receptor for the S protein of SARS-CoV-2 and inhibition of TMPRSS2, which is required for S protein priming may prevent cell entry of SARS-CoV-2. Further, chloroquine and hydroxychloroquine, and off-label antiviral drugs, such as the nucleotide analogue remdesivir, HIV protease inhibitors lopinavir and ritonavir, broad-spectrum antiviral drugs arbidol and favipiravir as well as antiviral phytochemicals available to date may limit spread of SARS-CoV-2 and morbidity and mortality of COVID-19 pandemic.


Pharmacol Res


Pharmacological research


McKee DL,Sternberg A,Stange U,Laufer S,Naujokat C




Has Abstract


2020-07-01 00:00:00












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    authors: Yin C,Tian Y,Yu Y,Li D,Miao Z,Su P,Zhao Y,Wang X,Pei J,Zhang K,Qian A

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  • Postmenopausal exogenous hormone therapy and Melanoma risk in women: A systematic review and time-response meta-analysis.

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    authors: Bakkali Nadi A,Zhang TM,Malaisse WJ

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    authors: Fleming I

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  • Simvastatin improves the attenuated heart rate recovery of type 2 diabetics.

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    authors: Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

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    pub_type: 杂志文章


    authors: Altunkan A,Aydin O,Ozer Z,Colak T,Bilgin E,Oral U

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    pub_type: 杂志文章,评审


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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kheifets V,Mochly-Rosen D

    更新日期:2007-06-01 00:00:00

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    authors: Deng SL,Hu ZL,Mao L,Gao B,Yang Q,Wang F,Chen JG

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    authors: Garrido-Moreno V,Díaz-Vegas A,López-Crisosto C,Troncoso MF,Navarro-Marquez M,García L,Estrada M,Cifuentes M,Lavandero S

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    authors: Bazrgar M,Khodabakhsh P,Mohagheghi F,Prudencio M,Ahmadiani A

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    pub_type: 杂志文章,评审


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    authors: Zhang P,Ling L,Zheng Z,Zhang Y,Wang R,Wu M,Zhang N,Hu M,Yang X

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    abstract::Parkinson's disease is a progressive age-related neurodegenerative disease with invariant loss of substantia nigra dopamine neurons and striatal projections. This disorder is well known for the associated motoric symptoms including resting tremor and the inability to initiate movement. However, it is now apparent that...

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    pub_type: 杂志文章,评审


    authors: Maguire-Zeiss KA

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    authors: Liu K,Zhang X,Xie L,Deng M,Chen H,Song J,Long J,Li X,Luo J

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    authors: Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

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    authors: Kim MJ,Lee JH,Park SY,Hong KW,Kim CD,Kim KY,Lee WS

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    authors: Khandker SK,Mukerjee D,Gurtu S,Pant KK,Dhawan KN,Sinha JN

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    pub_type: 杂志文章,评审


    authors: Mousavi SM,Hajishafiee M,Clark CCT,Borges do Nascimento IJ,Milajerdi A,Amini MR,Esmaillzadeh A

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Silva LP,Santos EC,Borges BA,Veloso MP,Chagas-Paula DA,Gonçalves RV,Novaes RD

    更新日期:2020-11-16 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Wang Y,Xu M,Ke ZJ,Luo J

    更新日期:2017-01-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kim J,Kim SM,Nguyen HC,Redondo MJ

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zheng L,Han X,Hu Y,Zhao X,Yin L,Xu L,Qi Y,Xu Y,Han X,Liu K,Peng J

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao H,Wang Z,Tang F,Zhao Y,Feng D,Li Y,Hu Y,Wang C,Zhou J,Tian X,Yao J

    更新日期:2018-02-01 00:00:00