Abstract：
:Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg(-1)day(-1)for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a deficient haemolysate due to the addition of TPP before incubation) were measured. The results indicated that, at doses of 20 and 30 mg kg(-1)(but not 10 mg kg(-1)), furosemide produced significant effects on these indices suggestive of thiamin deficiency. In another experiment, the effect of thiamin treatment (20 and 100 microg kg(-1)) in rats concomitantly given furosemide (30 mg kg(-1)) was investigated. The high dose of the vitamin was sufficient to overcome the biochemical signs of thiamin deficiency induced by furosemide.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Ali BH,Al-Qarawi AAdoi
10.1006/phrs.1999.0632keywords:
subject
Has Abstractpub_date
2000-07-01 00:00:00pages
21-4issue
1eissn
1043-6618issn
1096-1186pii
S1043-6618(99)90632-1journal_volume
42pub_type
杂志文章abstract：:In the field of kinase inhibitors for applications in cancer research, tubulin is emerging as a targeted cellular protein that can significantly contribute to their activities. However, investigation of kinase inhibitors beyond the kinome is an area often neglected. Herein, we describe the results of pharmacological s...
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journal_title：Pharmacological research
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pub_type： 临床试验,杂志文章
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abstract：:The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...
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更新日期：2004-03-01 00:00:00
