Abstract:
:A study was carried out relating to the anticholinergic action of clonidine on the cardiovascular responses to i.c.v. injection of neostigmine, a quaternary anticholinesterase, in conscious sham-operated animals and rats with sinoaortic denervation, 7 days after the corresponding operation. Neostigmine (0.1-1 micrograms i.c.v.) induced a dose-dependent pressor and bradycardic responses in sham-operated rats but induced only an increase in blood pressure in sinoaortic-denervated animals. However, the pressor response in sinoaortic-denervated rats was significantly greater than in sham-operated animals. Clonidine (10 micrograms kg-1 i.v.) induced a fall in mean arterial pressure in sinoaortic-denervated rats but not in sham-operated animals. Moreover, sinoaortic denervation reduced the bradycardic action of this antihypertensive drug. The anticholinesterase activity of clonidine (10 micrograms kg-1 i.v.), given 30 min previously, prevented the bradycardic action of neostigmine (0.1-1 micrograms i.c.v.) but failed to modify the pressor effect in sham-operated rats. This alpha2-adrenergic agent reduced the pressor response to i.c.v. administration of neostigmine in sinoaortic-denervated rats. Alternatively, the i.c.v. administration of clonidine (3 micrograms i.c.v.), given either 15 or 30 min before neostigmine, only prevented the bradycardic effect of the anticholinesterase (0.3 micrograms i.c.v.) in sham-operated rats but not the pressor action of this drug. In sinoaortic denervated rats, 3 micrograms of clonidine i.c.v. reduced an increase in blood pressure by i.c.v. injection of the anticholinesterase. The results suggest different central cholinergic mechanisms and different cholinergic-adrenergic interactions on the cardiovascular responses elicited by centrally injected neostigmine in sinoaortic denervated rats.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Taira CAdoi
10.1006/phrs.1997.0295subject
Has Abstractpub_date
1998-04-01 00:00:00pages
255-63issue
4eissn
1043-6618issn
1096-1186pii
S1043-6618(97)90295-4journal_volume
37pub_type
杂志文章abstract::It is well known that type 2 diabetes mellitus is frequently associated with vascular dysfunction and an elevated systemic blood pressure, yet the underlying mechanisms are not completely understood. We previously reported that in mesenteric arteries from established type 2 diabetic Otsuka Long-Evans Tokushima fatty (...
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1996.0057
更新日期:1996-07-01 00:00:00
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doi:10.1016/j.phrs.2014.02.001
更新日期:2014-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1006/phrs.1997.0225
更新日期:1997-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/s1043-6618(05)80084-2
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pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1999.0595
更新日期:2000-03-01 00:00:00
abstract::Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...
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更新日期:2018-04-01 00:00:00
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更新日期:2005-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.phrs.2006.12.008
更新日期:2007-04-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,meta分析,评审
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更新日期:2016-08-01 00:00:00
abstract::Neuronal damage following cerebral ischemia is mediated by various mechanisms, among which nitrosative stress plays an important role. Peroxynitrite, a powerful oxidant, contributes heavily to the neuronal damage in cerebral ischemic-reperfusion (IR) injury. In the present study, we have investigated the neuroprotecti...
journal_title:Pharmacological research
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doi:10.1016/j.phrs.2007.01.002
更新日期:2007-04-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0464
更新日期:1999-06-01 00:00:00
abstract::Erdosteine was introduced in the market as a mucolytic agent for chronic pulmonary diseases more than 10 years ago. The drug contains two blocked sulphydryl groups one of which, after hepatic metabolization and opening of the thiolactone ring, becomes available both for the mucolytic and free radical scavenging and an...
journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2006.12.006
更新日期:2007-04-01 00:00:00