Role of aldehyde dehydrogenase in the biological activity of spermine dialdehyde, a novel immunosuppressive/purging agent.

abstract：INTRODUCTION:Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the func...

journal_title：Pharmacological research

authors： Silva DF,Wenceslau CF,Mccarthy CG,Szasz T,Ogbi S,Webb RC

更新日期：2019-09-01 00:00:00

abstract：:Purine release and prostaglandin (PG) outflow were simultaneously evaluated from untreated glial primary cultures of rat striatum, at rest and under field electrical stimulation. Purine release was also assayed from sister cultured cells in which a suitable pharmacological treatment with 1 x 10(-6) M dexamethasone or ...

journal_title：Pharmacological research

authors： Caciagli F,Ciccarelli R,Di Iorio P,Tacconelli L,Ballerini P

更新日期：1989-05-01 00:00:00

abstract：:In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted a...

journal_title：Pharmacological research

authors： Pistollato F,Forbes-Hernández TY,Calderón Iglesias R,Ruiz R,Elexpuru Zabaleta M,Cianciosi D,Giampieri F,Battino M

更新日期：2020-02-01 00:00:00

abstract：:Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we explored the pain-relief potential of a pepducin series derived from ...

journal_title：Pharmacological research

authors： Brouillette RL,Besserer-Offroy É,Mona CE,Chartier M,Lavenus S,Sousbie M,Belleville K,Longpré JM,Marsault É,Grandbois M,Sarret P

更新日期：2020-05-01 00:00:00

abstract：:The isolated heart is deservedly one of the most popular experimental models in cardiovascular research, both in terms of cost and the quality and quantity of data it provides. However, it is a deceptively simple model, capable of throwing many problems in the path of the inexperienced or unwary perfuser. The followin...

journal_title：Pharmacological research

authors： Sutherland FJ,Hearse DJ

更新日期：2000-06-01 00:00:00

abstract：:DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

journal_title：Pharmacological research

authors： Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

更新日期：2010-02-01 00:00:00

abstract：:The EEG and behavioural changes induced by the administration of polyamines (spermine and spermidine) were studied in rabbit. Spermine and spermidine were administered at different doses (200 and 400 micrograms) into the mesencephalic ventricle (i.c.v.) both as a bolus and in constant perfusion (60 min duration). We a...

journal_title：Pharmacological research

authors： Bo P,Giorgetti A,Camana C,Savoldi F

更新日期：1990-07-01 00:00:00

abstract：:Etifoxine (EFX) is a non-benzodiazepine psychoactive drug which exhibits anxiolytic effects through a dual mechanism, by directly binding to GABAA receptors (GABAARs) and to the mitochondrial 18-kDa translocator protein, resulting in the potentiation of the GABAergic function. The β subunit subtype plays a key role in...

journal_title：Pharmacological research

authors： Mattei C,Taly A,Soualah Z,Saulais O,Henrion D,Guérineau NC,Verleye M,Legros C

更新日期：2019-07-01 00:00:00

abstract：:CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

journal_title：Pharmacological research

authors： Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

更新日期：2014-03-01 00:00:00

abstract：:In the present study, an attempt has been made to elucidate the role of alpha 2-adrenoceptors in reserpine-induced emesis in pigeons. Reserpine was found to induce dose-dependent emesis and a 500 micrograms kg-1 dose was found to be the 100% emetic dose. alpha 2-adrenoceptor agonists clonidine and alpha-methylnoradren...

journal_title：Pharmacological research

authors： Khandker SK,Mukerjee D,Gurtu S,Pant KK,Dhawan KN,Sinha JN

更新日期：1994-05-01 00:00:00

abstract：:The mechanisms involved in enhanced cough induced by central and inhaled NGF in guinea pigs were investigated. Cough and airway function were assessed by plethysmography following inhaled or intracerebroventricular (i.c.v.) NGF treatment. Expression of TrkA and/or TRPV1 was determined in bronchi and/or brainstem by re...

journal_title：Pharmacological research

authors： El-Hashim AZ,Jaffal SM,Al-Rashidi FT,Luqmani YA,Akhtar S

更新日期：2013-08-01 00:00:00

abstract：:An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

journal_title：Pharmacological research

authors： Giacobini E

更新日期：2004-10-01 00:00:00

abstract：:The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of...

journal_title：Pharmacological research

authors： Alama A,Barbieri F,Cagnoli M,Schettini G

更新日期：1997-09-01 00:00:00

abstract：:Exposure to ionizing radiation causes damage to living tissues; however, only a small number of agents have been approved for use in radiation injuries. Radioprotector is the primary countermeasure to radiation injury and none radioprotector has indeed reached the drug development stage. Repurposing the long list of a...

journal_title：Pharmacological research

authors： Ren L,Xie D,Li P,Qu X,Zhang X,Xing Y,Zhou P,Bo X,Zhou Z,Wang S

更新日期：2016-11-01 00:00:00

abstract：:Radiotherapy plays a critical role in the treatment of non-small cell lung cancer (NSCLC). However, radioresistance is a major barrier against increasing the efficiency of radiotherapy for NSCLC. To understand the mechanisms underlying NSCLC radioresistance, we previously focused on the potential involvement of PIM1, ...

journal_title：Pharmacological research

authors： Kim W,Youn H,Kwon T,Kang J,Kim E,Son B,Yang HJ,Jung Y,Youn B

更新日期：2013-04-01 00:00:00

abstract：:Over the past decade, poly(ADP-ribosyl)ation has emerged as a crucial event in the pathogenesis of ischemic stroke. A large body of evidence unambiguously demonstrates that activity of poly(ADP-ribose) polymerase-1 (PARP-1) significantly increases during brain ischemia, and that inhibition of this enzymatic activity a...

journal_title：Pharmacological research

authors： Chiarugi A

更新日期：2005-07-01 00:00:00

abstract：:The gut microbiota and its short chain fatty acid (SCFA) metabolites have been established to play an important protective role against neurodegenerative diseases. Our previous study demonstrated that cerebral ischemic stroke triggers dysfunctional gut microbiota and increased intestinal permeability. In this study, w...

journal_title：Pharmacological research

authors： Chen R,Xu Y,Wu P,Zhou H,Lasanajak Y,Fang Y,Tang L,Ye L,Li X,Cai Z,Zhao J

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...

journal_title：Pharmacological research

authors： Korolkiewicz RP,Tashima K,Fujita A,Kato S,Takeuchi K

更新日期：2000-02-01 00:00:00

abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...

journal_title：Pharmacological research

authors： Misirkic M,Janjetovic K,Vucicevic L,Tovilovic G,Ristic B,Vilimanovich U,Harhaji-Trajkovic L,Sumarac-Dumanovic M,Micic D,Bumbasirevic V,Trajkovic V

更新日期：2012-01-01 00:00:00

abstract：:Secretion of matrix metalloproteinases (MMPs) by macrophages and smooth muscle cells (SMC) may impair atherosclerotic cap integrity leading to atherosclerosis complications. Selective estrogen receptor modulators (SERMs) have favourable impact on plasma lipid levels, but their role in the prevention of atherosclerosis...

journal_title：Pharmacological research

authors： Bellosta S,Baetta R,Canavesi M,Comparato C,Granata A,Monetti M,Cairoli F,Eberini I,Puglisi L,Corsini A

更新日期：2007-08-01 00:00:00

abstract：:Ranolazine has characteristic properties of a selective inhibitor of the inward sodium current. It is primarily indicated as an anti-anginal agent in patients with coronary artery disease and chronic stable angina. Recently, ranolazine has been noted to possibly impart beneficial effects in various other cardiac condi...

journal_title：Pharmacological research

authors： Mihos CG,Krishna RK,Kherada N,Larrauri-Reyes M,Tolentino A,Santana O

更新日期：2016-01-01 00:00:00

abstract：:Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject of increasing attention. Boldine, in particular, the major and most characteristic alkaloidal con...

journal_title：Pharmacological research

authors： Speisky H,Cassels BK

更新日期：1994-01-01 00:00:00

abstract：:Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...

journal_title：Pharmacological research

authors： al-Zuhair H,el-Sayeh B,Ameen HA,al-Shoora H

更新日期：1996-07-01 00:00:00

abstract：:Myriocin, a potent inhibitor of serine palmitoyltransferase (SPT), has been shown to reduce plasma sphingolipids, cholesterol and triglycerides in hyperlipidemic apolipoprotein E knockout (apoE KO) mice. We hypothesized that the inhibition of sphingolipid biosynthesis modulates the composition of atherosclerotic plaqu...

journal_title：Pharmacological research

authors： Park TS,Rosebury W,Kindt EK,Kowala MC,Panek RL

更新日期：2008-07-01 00:00:00

abstract：:The role of the angiotensin AT1 receptors in certain behavioural effects of angiotensin II (Ang II), using their selective antagonist losartan (DuP 753), was assessed. Ang II, given intracerebroventricularly (ICV) at the dose of 1 nmole, significantly improved object recognition, learning of conditioned avoidance resp...

journal_title：Pharmacological research

authors： Kułakowska A,Karwowska W,Wiśniewski K,Braszko JJ

更新日期：1996-09-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

journal_title：Pharmacological research

authors： Shimomura Y,Kitaura Y

更新日期：2018-07-01 00:00:00

abstract：:Monoclonal antibodies (mAb) have revolutionised the way in which we treat disease. From cancer to autoimmunity, antibody therapy has been responsible for some of the most impressive clinical responses observed in the last 2 decades. A key component of this success has been their generally low levels of toxicity, and u...

journal_title：Pharmacological research

authors： Vaughan AT,Cragg MS,Beers SA

更新日期：2015-09-01 00:00:00

abstract：:To minimize irreversible brain injury after acute ischemic stroke (AIS), the time to treatment (i.e., treatment delay) should be minimized. However, thus far, all cytoprotective clinical trials have failed. Analysis of literature identified short treatment durations (≤72 h) as a common motif among completed cytoprotec...

journal_title：Pharmacological research

authors： Gaidhani N,Uteshev VV

更新日期：2018-10-01 00:00:00

abstract：:Implantable cardioverter-defibrillators (ICDs) have revolutionized the primary and secondary prevention of patients with ventricular arrhythmias. However, the adverse effects of appropriate or inappropriate shocks may require the adjunctive use of anti-arrhythmic drugs (AADs). Beta blockers are the cornerstone of phar...

journal_title：Pharmacological research

authors： AlTurki A,Proietti R,Russo V,Dhanjal T,Banerjee P,Essebag V

更新日期：2019-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

journal_title：Pharmacological research

authors： Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

更新日期：2020-12-08 00:00:00