Abstract：
:The role of the angiotensin AT1 receptors in certain behavioural effects of angiotensin II (Ang II), using their selective antagonist losartan (DuP 753), was assessed. Ang II, given intracerebroventricularly (ICV) at the dose of 1 nmole, significantly improved object recognition, learning of conditioned avoidance responses (CARs), and recall of a passive avoidance behaviour. Losartan alone (1 microgram) was ineffective in any test except for the elevated 'plus' maze measuring anxiety which was diminished by the drug, both in peptide treated and in control rats. Losartan, given 5 min before Ang II, abolished improved after the peptide recall of the passive avoidance and object recognition. Losartan did not influence increased after Ang II rate of CARs acquisition. None of the treatments significantly changed behaviour of rats in the open field. The results point to the considerable involvement of the AT1 angiotensin receptors in the cognition improving effects of Ang II. However, unspecific psychoactivity of losartan should also be taken into account.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Kułakowska A,Karwowska W,Wiśniewski K,Braszko JJdoi
10.1006/phrs.1996.0073subject
Has Abstractpub_date
1996-09-01 00:00:00pages
109-15issue
3-4eissn
1043-6618issn
1096-1186pii
S1043-6618(96)90073-0journal_volume
34pub_type
杂志文章abstract：:Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK3-receptors on allergen-induced pulmonary inflammation, studies were performed on ovalbumin (OVA) sensitized and challen...
journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：1995-09-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2003-12-01 00:00:00
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更新日期：2004-01-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2019-02-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.2000.0673
更新日期：2000-08-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2020-11-16 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2005.05.014
更新日期：2005-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2018-07-01 00:00:00
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journal_title：Pharmacological research
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
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更新日期：2017-04-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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doi：10.1006/phrs.1997.0225
更新日期：1997-09-01 00:00:00
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abstract：:Osteopontin (OPN) is known as an active player in the progression of vascular remodeling diseases, however, the precise role in the proliferation of vascular smooth muscle cells (VSMC) is unclear. Thus, this study investigated the role of OPN in VSMC proliferation induced by 4-hydroxynonenal (HNE), and identified the ...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2016-06-01 00:00:00
abstract：:Melanoma is a highly invasive and metastatic cancer with high mortality rates and chemoresistance. Around 50% of melanomas are driven by activating mutations in BRAF that has led to the development of potent anti-BRAF inhibitors. However resistance to anti-BRAF therapy usually develops within a few months and conseque...
journal_title：Pharmacological research
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更新日期：2017-11-01 00:00:00
