Abstract：
:In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sensitivity of the intestinal parts to both the above substances increases from the duodenum to the ileum. Ketamine produces a non-competitive inhibition of the GABA- and muscimol-induced contractions of the ileum, while it does not influence the ileal cholinergic contractions induced by exogenous acetylcholine. These results suggest that ketamine may modify intestinal motility through its antagonistic action at the GABAA-receptor complex.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Kounenis G,Koutsoviti-Papadopoulou M,Elezoglou Vdoi
10.1016/1043-6618(95)80086-7subject
Has Abstractpub_date
1995-06-01 00:00:00pages
337-40issue
6eissn
1043-6618issn
1096-1186pii
1043-6618(95)80086-7journal_volume
31pub_type
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