Abstract：
:Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspension every other day for 10 days. Arthritis was induced by a heat-killed Mycobacterium butyricum suspension. Reactive oxygen species (ROS) produced by macrophages, and splenic superoxide dismutase (total, cytoplasmic and mitochondrial) and catalase activities were determined. Clinically, joint swelling in arthritic rats was not reduced by antioxidants; however, the 5% cocoa diet and quercetin administration reduced ROS production. Moreover, the 5% cocoa diet normalized the activities of superoxide dismutase and catalase. In conclusion, a cocoa diet reduces the oxidative stress associated with a chronic inflammatory pathology, although it was not enough to attenuate joint swelling.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Ramos-Romero S,Pérez-Cano FJ,Ramiro-Puig E,Franch A,Castell Mdoi
10.1016/j.phrs.2012.05.009subject
Has Abstractpub_date
2012-09-01 00:00:00pages
207-12issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(12)00117-Xjournal_volume
66pub_type
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