Nutraceuticals: An emerging therapeutic approach against the pathogenesis of Alzheimer's disease.


:Alzheimer's disease (AD) is regarded as a progressive and devastating neurodegenerative disorder. In aged individuals, it is the most prevalent cause of dementia and is characterized by gradual loss of cognitive functions. In the last decade, numerous research works were undertaken to investigate the pathogenesis of AD. Although the etiology of AD is still not clear, several histopathological studies confirm prominent changes in the AD affected brains. The major changes include the formation of senile plaques and neurofibrillary tangles primarily owing to the deposition of amyloid β plaques (Aβ) and hyper-phosphorylation of tau protein. Disruption of the redox homeostasis in the brain is a major triggering factor for the development of such pathophysiological conditions. Chemical formulations usually act by inhibiting activities of the enzymes responsible for the development of AD. But with time, these pharmacotherapies develop many side effects including toxicity in different organs. Recent researches are henceforth focused on the identification of novel therapeutic molecules from the nature's basket. This review aims to emphasize the therapeutic effects and regulation of molecular targets of different natural products such as curcumin, resveratrol, genistein and others. These prophylactic multipotent natural compounds have the potency to interfere with the formation as well as deposition of the Aβ peptides. These natural compounds have also been found in modulating different intracellular signalling molecules and enzymes including β-secretase and γ-secretase. This review article is expected to be helpful in understanding the recent progress in natural product research as a therapeutic approach in amelioration and/or delaying the detrimental effects of AD.


Pharmacol Res


Pharmacological research


Sadhukhan P,Saha S,Dutta S,Mahalanobish S,Sil PC




Has Abstract


2018-03-01 00:00:00












  • Pyridoxol L,2-pyrrolidon-5 carboxylate prevents active fibroplasia in CCl4-treated rats.

    abstract::In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

    更新日期:1992-01-01 00:00:00

  • Prescribing habits of general practitioners in choosing an empirical antibiotic regimen for lower respiratory tract infections in adults in Sicily.

    abstract::The survey was carried out, between September 1995 and May 1996, in order to describe the prescriptive behaviour among Sicilian general practitioners (GPs) in choosing an empirical antibiotic regimen for LRTIs in adult patients and begin an educational process which involves the same GPs in decisions regarding their p...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mazzaglia G,Arcoraci V,Greco S,Cucinotta G,Cazzola M,Caputi AP

    更新日期:1999-07-01 00:00:00

  • Advances into Understanding the Vital Role of the Mitochondrial Citrate Carrier (CIC) in Metabolic Diseases.

    abstract::The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found i...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Peng R,Zhang M,Wang H,Lin J,Wang H,Wang F,Liu L,Zhao Q,Liu J

    更新日期:2020-11-01 00:00:00

  • Dual role of betel leaf extract on thyroid function in male mice.

    abstract::The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panda S,Kar A

    更新日期:1998-12-01 00:00:00

  • Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions.

    abstract::Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Shimomura Y,Kitaura Y

    更新日期:2018-07-01 00:00:00

  • Gas chromatographic assay for estazolam in human plasma and results of a bioequivalence study.

    abstract::This paper describes a new sensitive gas chromatographic method with electron capture detector to assay estazolam in human plasma, which has been developed and validated for pharmacokinetic purposes. The drug and the internal standard (triazolam) were extracted from plasma buffered at pH 9.0 into toluene and analysed ...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Dal Bo L,Verga F,Marzo A,La Commare P,De Vito ML

    更新日期:1997-04-01 00:00:00

  • Insulinotropic action of novel succinic acid esters.

    abstract::The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succini...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Björkling F,Malaisse-Lagae F,Malaisse WJ

    更新日期:1996-04-01 00:00:00

  • CAR-T cells and combination therapies: What's next in the immunotherapy revolution?

    abstract::Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ramello MC,Haura EB,Abate-Daga D

    更新日期:2018-03-01 00:00:00

  • Anti-diabetic effects of Gymnema yunnanense extract.

    abstract::In this study, we evaluated anti-hyperglycemic effect and body weight reduction activity of Gymnema yunnanense extract in obese ob/ob and diabetic db/db mice. Animals received daily intraperitoneal injections of the extract 100 mg/kg for 12 days. On Day 5, the extract-treated ob/ob mice had significantly lower fasting...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xie JT,Wang A,Mehendale S,Wu J,Aung HH,Dey L,Qiu S,Yuan CS

    更新日期:2003-04-01 00:00:00

  • Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases.

    abstract::The Janus kinase (JAK) family of non-receptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (tyrosine kinase-2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that regulates the adjacent protein kinase domain (JH1). JAK1/2 and TYK2 are ubiquitously expressed whereas JAK3 is...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Roskoski R Jr

    更新日期:2016-09-01 00:00:00

  • Potential efficacy of a delta 5-aminolevulinic acid thermosetting gel formulation for use in photodynamic therapy of lesions of the gastrointestinal tract.

    abstract::Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Bourre L,Thibaut S,Briffaud A,Lajat Y,Patrice T

    更新日期:2002-02-01 00:00:00

  • Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

    abstract::Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of p...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Nadeem A,Al-Harbi NO,Al-Harbi MM,El-Sherbeeny AM,Ahmad SF,Siddiqui N,Ansari MA,Zoheir KM,Attia SM,Al-Hosaini KA,Al-Sharary SD

    更新日期:2015-09-01 00:00:00

  • Effects of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of proton pump inhibitors.

    abstract::Proton pump inhibitors (PPIs) are used widely for the treatment of acid-related disorders. Despite their excellent efficacy and tolerance, the pharmacodynamics and pharmacokinetics of PPIs are affected by each patient's CYP2C19 and gastric H+,K+-ATPase genotype. The aim of this review was to analyze the effect of gene...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zhang HJ,Zhang XH,Liu J,Sun LN,Shen YW,Zhou C,Zhang HW,Xie LJ,Chen J,Liu Y,Wang YQ

    更新日期:2020-02-01 00:00:00

  • The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials.

    abstract::Dyslipidemia and hyperglycemia are associated with an increased risk of ischemic cardiovascular disease. Positive effects of a nutraceutical combination comprising red yeast rice, berberine, policosanol, astaxanthin, coenzyme Q10 and folic acid (NComb) on plasma lipid and glucose levels have been reported in some but ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,meta分析,评审


    authors: Pirro M,Mannarino MR,Bianconi V,Simental-Mendía LE,Bagaglia F,Mannarino E,Sahebkar A

    更新日期:2016-08-01 00:00:00

  • Synoptic pharmacology: Detecting and assessing the pharmacological significance of ligands for orphan receptors.

    abstract::This paper discusses the discovery of ligands for orphan receptors and the identification of the natural endogenous ligands for those receptors in physiology. The central thesis is that orphan seven transmembrane receptors (7TMRs) are allosteric conduits of chemical information exchange from extracellular ligands to i...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kenakin TP

    更新日期:2016-12-01 00:00:00

  • Selectivity of blocking of low- versus high-voltage activated calcium currents by the dihydropyridine derivatives Bay E5759 and Bay A4339 in neuroblastoma--glioma NG 108-15 cells.

    abstract::Beneficial therapeutic effects of dihydropyridine derivatives in cardiovascular and neurological disorders are often associated with selective L-type Ca(2+)channel blockade. Here the new dihydropyridine derivatives Bay E5759 (1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl-1-methylethyl ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Himmel HM,Stengel W,Ravens U

    更新日期:2001-08-01 00:00:00

  • DNA microarray analysis of white adipose tissue from obese (fa/fa) Zucker rats treated with a beta3-adrenoceptor agonist, KTO-7924.

    abstract::We aimed to examine the effects of KTO-7924 (beta3-adrenoceptor agonist) on lipid metabolism and mRNA expressions in retroperitoneal white adipose tissue (RP WAT) in obese (fa/fa) Zucker rats using DNA microarray. Oral KTO-7924 for 28 days significantly decreased RP WAT weight, plasma triglyceride, free fatty acid, an...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Oana F,Homma T,Takeda H,Matsuzawa A,Akahane S,Isaji M,Akahane M

    更新日期:2005-11-01 00:00:00

  • A pharmacological assessment of agonists and modulators at α4β2γ2 and α4β2δ GABAA receptors: The challenge in comparing apples with oranges.

    abstract::Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the presence of a δ subunit in the receptor complex. δ-Containing receptors respond to low ambient concentrations of GABA, or respond to spillover of GABA from the synapse, and give rise to tonic inhibitory currents. In ce...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ahring PK,Bang LH,Jensen ML,Strøbæk D,Hartiadi LY,Chebib M,Absalom N

    更新日期:2016-09-01 00:00:00

  • Effects of ropivacaine, bupivacaine and sufentanil in colon and pancreatic cancer cells in vitro.

    abstract::The perioperative period is supposed to be a vulnerable period for cancer progression. Results of clinical studies indicate that the use of regional anesthesia can influence and improve oncological outcome of cancer patients. Uncontrolled cell proliferation and resistance to apoptotic cell death are important characte...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Bundscherer A,Malsy M,Gebhardt K,Metterlein T,Plank C,Wiese CH,Gruber M,Graf BM

    更新日期:2015-05-01 00:00:00

  • Control of salt intake by steroids and cerebral peptides.

    abstract::Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Epstein AN

    更新日期:1992-02-01 00:00:00

  • In vitro physiological evidence of enhanced antioxidant and neuroprotective action of 2,3-dihydromelatonin, a melatonin analogue.

    abstract::As the capacity of the endogenous antioxidative system is limited, pharmacological treatment with antioxidants may help to protect neuronal tissue against increased amount of reactive oxygen species produced during oxidative stress. We attempted to improve resistance of rat hippocampal slices exposed to ischaemia in v...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gáspárová Z,Stolc S,Snirc V

    更新日期:2006-01-01 00:00:00

  • Histamine in diabetes: Is it time to reconsider?

    abstract::The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an inc...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Pini A,Obara I,Battell E,Chazot PL,Rosa AC

    更新日期:2016-09-01 00:00:00


    abstract::Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patient...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ahaneku JE,Sakata K,Urano T,Takada Y,Takada A

    更新日期:2000-01-01 00:00:00

  • To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling.

    abstract::Sphingosine 1-phosphate (S1P) is an extracellular lipid signaling molecule that acts as a selective, high-affinity ligand for a family of five G protein-coupled receptors. This signaling system was first identified twenty years ago, and has since been shown to regulate a diverse range of physiological processes and di...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Chew WS,Wang W,Herr DR

    更新日期:2016-11-01 00:00:00

  • Time-dependent reduction of acetylcholine-induced relaxation in aortic rings of cholestatic rats.

    abstract::Changes in vascular responsiveness are the basis for some of the cardiovascular complications in cholestasis. Since the duration of cholestasis is important in determining the degree of the complications, we investigated the time-course dependent evolution of vascular relaxation responsiveness in the aortic rings of c...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Rastegar H,Jorjani M,Roushanzamir F,Ahmadiani A,Namiranian K,Dehpour AR

    更新日期:2001-12-01 00:00:00

  • FeTPPS protects against global cerebral ischemic-reperfusion injury in gerbils.

    abstract::Neuronal damage following cerebral ischemia is mediated by various mechanisms, among which nitrosative stress plays an important role. Peroxynitrite, a powerful oxidant, contributes heavily to the neuronal damage in cerebral ischemic-reperfusion (IR) injury. In the present study, we have investigated the neuroprotecti...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sharma SS,Dhar A,Kaundal RK

    更新日期:2007-04-01 00:00:00

  • Important roles of protein tyrosine phosphatase PTPN12 in tumor progression.

    abstract::Protein tyrosine phosphatases (PTPs), which are ubiquitously expressed in hematopoietic and non-hematopoietic cells, are critical for regulating cell proliferation as well as differentiation in the physiology of multicellular organisms. PTPs regulate the intracellular signaling mechanism of immune cells via dephosphor...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Lee C,Rhee I

    更新日期:2019-06-01 00:00:00

  • Cyproterone acetate and reversal of the impaired endometrial decidualization in streptozotocin-diabetic pseudopregnant rats.

    abstract::Reproductive dysfunction in the female diabetic rat is associated with impaired hypothalamic-hypophyseal system, anovulation, insufficiency of ovarian steroidogenesis and spontaneous failure of pregnancy. Formation of decidua, the highly modified endometrium of pregnancy and pseudopregnancy could only be achieved when...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zakaria R,Ismail Z,Chatterjee A

    更新日期:2000-08-01 00:00:00

  • Pharmacogenomic analyzis of the responsiveness of gastrointestinal tumor cell lines to drug therapy: A transportome approach.

    abstract::In this study, we have addressed the pharmacogenomic basis of the response of gastrointestinal tumors to six anticancer drugs using a panel of fifteen cell lines derived from pancreatic, stomach and biliary tract cancers. We determined the constitutive expression levels of 96 genes, whose encoded proteins contribute t...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Grañé-Boladeras N,Pérez-Torras S,Lozano JJ,Romero MR,Mazo A,Marín JJG,Pastor-Anglada M

    更新日期:2016-11-01 00:00:00

  • The importance of regulating the education and training of Traditional Chinese Medicine practitioners and a potential role for ISO/TC 249.

    abstract::As Traditional Chinese Medicine (TCM) transcends its cultural boundaries and becomes widely used in many countries around the world, one of the major risks to the growing use of TCM internationally is the damage caused to its reputation and to community safety when TCM practitioners are not adequately trained. Ensurin...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Li J,Graham D

    更新日期:2020-11-01 00:00:00