Pre-Eclampsia: Microbiota possibly playing a role.


:Pre-eclampsia (PE) is a complication of pregnancy that is associated with mortality and morbidity in mothers and fetuses worldwide. Oxygen dysregulation in the placenta, abnormal remodeling of the spiral artery, defective placentation, oxidative stress at the fetal-maternal border, inflammation and angiogenic impairment in the maternal circulation are the main causes of this syndrome. These events result in a systemic and diffuse endothelial cell dysfunction, an essential pathophysiological feature of PE. The impact of bacteria on the multifactorial pathway of PE is the recent focus of scientific inquiry since microbes may cause each of the aforementioned features. Microbes and their derivatives by producing antigens and other inflammatory factors may trigger infection and inflammatory responses. A mother's bacterial communities in the oral cavity, gut, vagina, cervix and uterine along with the placenta and amniotic fluid microbiota may be involved in the development of PE. Here, we review the mechanistic and pathogenic role of bacteria in the development of PE. Then, we highlight the impact of alterations in a set of maternal microbiota (dysbiosis) on the pathogenesis of PE.


Pharmacol Res


Pharmacological research


Ahmadian E,Rahbar Saadat Y,Hosseiniyan Khatibi SM,Nariman-Saleh-Fam Z,Bastami M,Zununi Vahed F,Ardalan M,Zununi Vahed S




Has Abstract


2020-05-01 00:00:00












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    journal_title:Pharmacological research

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:Pharmacological research

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    authors: Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

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    authors: el-Batran SA,el-Shenawy SM,Nofal SM,Abdel-Salam OM,Arbid MS

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lauritzen B,Lykkesfeldt J,Djurup R,Flodgaard H,Svendsen O

    更新日期:2005-06-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Besserer-Offroy É,Bérubé P,Côté J,Murza A,Longpré JM,Dumaine R,Lesur O,Auger-Messier M,Leduc R,Marsault É,Sarret P

    更新日期:2018-05-01 00:00:00


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    pub_type: 杂志文章,评审


    authors: Sharma A,Gupta S,Chauhan S,Nair A,Sharma P

    更新日期:2020-08-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Seedher N,Bhatia S

    更新日期:2006-08-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2003-12-01 00:00:00

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    authors: Korolkiewicz RP,Konstański Z,Rekowski P,Ruczyński J,Szyk A,Dabkowski J,Ujda M,Korolkiewicz KZ,Petrusewicz J

    更新日期:2001-07-01 00:00:00

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    pub_type: 杂志文章,meta分析


    authors: Barylski M,Nikfar S,Mikhailidis DP,Toth PP,Salari P,Ray KK,Pencina MJ,Rizzo M,Rysz J,Abdollahi M,Nicholls SJ,Banach M,Lipid and Blood Pressure Meta-Analysis Collaboration Group.

    更新日期:2013-06-01 00:00:00

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    pub_type: 杂志文章


    authors: McCarthy CG,Wenceslau CF,Goulopoulou S,Ogbi S,Matsumoto T,Webb RC

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    pub_type: 杂志文章


    authors: Pitsikas N,Rigamonti AE,Cella SG,Muller EE

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    pub_type: 杂志文章,评审


    authors: Gupta S,Sen U

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    pub_type: 杂志文章,meta分析,评审


    authors: Dinca M,Serban MC,Sahebkar A,Mikhailidis DP,Toth PP,Martin SS,Blaha MJ,Blüher M,Gurban C,Penson P,Michos ED,Hernandez AV,Jones SR,Banach M,for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Matsumoto T,Ishida K,Nakayama N,Taguchi K,Kobayashi T,Kamata K

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    journal_title:Pharmacological research

    pub_type: 杂志文章


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    pub_type: 杂志文章


    authors: Ozmen I,Küfrevioglu OI

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  • The effects of doxazosin on plasma lipid and lipoprotein levels in hypertensive patients.

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    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Ahaneku JE,Taylor GO,Agbedana EO,Walker O,Salako LA

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Chae HJ,Kim SC,Chae SW,An NH,Kim HH,Lee ZH,Kim HR

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kim MJ,Lee JH,Park SY,Hong KW,Kim CD,Kim KY,Lee WS

    更新日期:2006-10-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Albiero M,Fadini GP

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Meldolesi J

    更新日期:2017-07-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Scandroglio A,Monferini E,Borsini F

    更新日期:2001-02-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Huang F,Li Y,Leung EL,Liu X,Liu K,Wang Q,Lan Y,Li X,Yu H,Cui L,Luo H,Luo L

    更新日期:2020-08-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Newton PM,Ron D

    更新日期:2007-06-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kenakin TP

    更新日期:2016-12-01 00:00:00

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    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Moyano-Porcile V,Olavarría-Ramírez L,González-Arancibia C,Bravo JA,Julio-Pieper M

    更新日期:2015-11-01 00:00:00