Notch in fibrosis and as a target of anti-fibrotic therapy.

Abstract:

:The Notch pathway represents a highly conserved signaling network with essential roles in regulation of key cellular processes and functions, many of which are critical for development. Accumulating evidence indicates that it is also essential for fibrosis and thus the pathogenesis of chronic fibroproliferative diseases in diverse organs and tissues. Different effects of Notch activation are observed depending on cellular and tissue context as well as in both physiologic and pathologic states. Close interactions of Notch signaling pathway with other signaling pathways have been identified. In this review, current knowledge on the role of the Notch signaling with special focus on fibrosis and its potential as a therapeutic target is summarized.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Hu B,Phan SH

doi

10.1016/j.phrs.2016.04.010

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

57-64

eissn

1043-6618

issn

1096-1186

pii

S1043-6618(16)30309-7

journal_volume

108

pub_type

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