Abstract:
:Several studies have demonstrated that any beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins), of which simvastatin (Merck Sharp & Dohme) is an example, on coronary events are linked to their hypocholesterolemic properties. The in vivo effects of simvastatin treatment on lipase (GEH = glycerol ester hydrolase) and cholesterol esterase (CEase) activity in the serum of men with coronary heart disease (CHD) were examined. GEH and CEase activity in the serum of men with CHD, before simvastatin treatment, was lower than in the control subjects. In our study we have provided evidence that simvastatin increases GEH activity in a time-dependent manner, but has no effect on CEase activity. This suggests that simvastatin can directly affect acylglycerol metabolism by an increase in GEH activity and may therefore be suitable for the treatment of combined lipoprotein disorders characterized by elevation of triacylglycerols.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Pioruńska-Stolzmann M,Pioruńska-Mikołajczak Adoi
10.1006/phrs.2000.0787keywords:
subject
Has Abstractpub_date
2001-04-01 00:00:00pages
359-62issue
4eissn
1043-6618issn
1096-1186pii
S1043661800907874journal_volume
43pub_type
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