Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.


:Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a correlation between GI dysfunction and the degree of social impairment in ASD. The etiology of GI abnormalities in ASD is unclear, though the association between GI dysfunction and ASD-associated behaviors suggest that overlapping developmental defects in the brain and the intestine and/or a defect in communication between the enteric and central nervous systems (ENS and CNS, respectively), known as the gut-brain axis, could be responsible for the observed phenotypes. Brain-gut abnormalities have been increasingly implicated in several disease processes, including ASD. As a critical modulator of ENS and CNS development and function, serotonin may be a nexus for the gut-brain axis in ASD. This paper reviews the role of serotonin in ASD from the perspective of the ENS. A murine model that has been demonstrated to possess brain, behavioral and GI abnormalities mimicking those seen in ASD harbors the most common serotonin transporter (SERT) based mutation (SERT Ala56) found in children with ASD. Discussion of the gut-brain manifestations in the SERT Ala56 mice, and their correction with developmental administration of a 5-HT4 agonist, are also addressed in conjunction with other future directions for diagnosis and treatment.


Pharmacol Res


Pharmacological research


Israelyan N,Margolis KG




Has Abstract


2018-06-01 00:00:00












  • Drugs preventing Na+ and Ca2+ overload.

    abstract::Cardiac intracellular Na+and Ca2+homeostasis is regulated by the concerted action of ion channels, pumps and exchangers. The Na+, K+-ATPase produces the electrochemical concentration gradient for Na+, which is the driving force for Ca2+removal from the cytosol via the Na+/Ca2+exchange. Reduction of this gradient by in...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ravens U,Himmel HM

    更新日期:1999-03-01 00:00:00

  • Effect of DL alpha-lipoic acid on tissue lipid peroxidation and antioxidant systems in normal and glycollate treated rats.

    abstract::The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decreas...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sumathi R,Jayanthi S,Kalpanadevi V,Varalakshmi P

    更新日期:1993-05-01 00:00:00

  • Green tea polyphenols produce antidepressant-like effects in adult mice.

    abstract::Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L

    更新日期:2012-01-01 00:00:00

  • Dual role of betel leaf extract on thyroid function in male mice.

    abstract::The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibite...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panda S,Kar A

    更新日期:1998-12-01 00:00:00

  • Prolonged effect of the tricyclic antidepressant, mianserin on the serotonin and histamine content of young rats' white blood cells and mast cells. A case of late-imprinting.

    abstract::Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Csaba G,Kovács P,Pállinger E

    更新日期:2003-11-01 00:00:00

  • Effect of benzyl isothiocyanate on spontaneous and induced force of rat uterine contraction.

    abstract::The present study examines the effect of benzyl isothiocyanate (BITC) on uterine contraction in vitro. BITC (10-320 microM) caused irreversible, concentration-dependent inhibition of the spontaneous, prostaglandin F(2alpha) (PGF(2alpha)) and oxytocin-induced force of gravid and non-gravid rat uterine contractions in c...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Adebiyi A,Adaikan PG,Prasad RN

    更新日期:2004-05-01 00:00:00

  • An overview of erdosteine antioxidant activity in experimental research.

    abstract::Erdosteine was introduced in the market as a mucolytic agent for chronic pulmonary diseases more than 10 years ago. The drug contains two blocked sulphydryl groups one of which, after hepatic metabolization and opening of the thiolactone ring, becomes available both for the mucolytic and free radical scavenging and an...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Moretti M,Marchioni CF

    更新日期:2007-04-01 00:00:00

  • Estrogenic activity of 7-hydroxymatairesinol potassium acetate (HMR/lignan) from Norway spruce (Picea abies) knots and of its active metabolite enterolactone in MCF-7 cells.

    abstract::Lignans are plant polyphenols which may possess anticancer, antioxidant, antimicrobial, anti-inflammatory and immunomodulatory activities. In particular, the lignan 7-hydroxymatairesinol (HMR/lignan, HMR) is a novel precursor of the mammalian lignan enterolactone (EL). In the present study, we investigated the estroge...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Cosentino M,Marino F,Ferrari M,Rasini E,Bombelli R,Luini A,Legnaro M,Delle Canne MG,Luzzani M,Crema F,Paracchini S,Lecchini S

    更新日期:2007-08-01 00:00:00

  • Evidence for a role of nitric oxide in the mediation of antiproliferative UVA effects in keratinocytes.

    abstract::Using cultured human keratinocytes, the present study investigates the role of nitric oxide (NO) in the mediation of the antiproliferative effects of ultraviolet light A (UVA). UVA treatment of cells (3-21 J cm (-2)) caused a time- and dose-dependent increase in nitrite formation in a micromolar range. This effect was...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Podhaisky HP,Klapperstück T,Riemschneider S,Wohlrab W

    更新日期:2002-03-01 00:00:00


    abstract::A bovine dopamine transporter (bDAT) cDNA was transfected into CV-1 cells, a cell line that lacks vesicular storage and release mechanisms. Using this cell line, the effects of neuroleptic drugs on DAT-mediated uptake and release of dopamine (DA) were examined. All of the neuroleptic drugs tested, inhibited DA uptakes...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lee Sh,Oh Dy,Jung Sc,Kim Ym,Cho Hk,Koh Jk,Lee Ys

    更新日期:1997-05-01 00:00:00

  • The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain.

    abstract::There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

    更新日期:2016-09-01 00:00:00

  • Carnosol-mediated Sirtuin 1 activation inhibits Enhancer of Zeste Homolog 2 to attenuate liver fibrosis.

    abstract::Quiescent hepatic stellate cell (HSC) activation and subsequent conversion into myofibroblasts is the central event in hepatic fibrosis pathogenesis. Epithelial-mesenchymal transition (EMT), another vital participant in liver fibrosis, has the potential to initiate HSC activation, which promotes abundant myofibroblast...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao H,Wang Z,Tang F,Zhao Y,Feng D,Li Y,Hu Y,Wang C,Zhou J,Tian X,Yao J

    更新日期:2018-02-01 00:00:00

  • Effect of sodium-glucose co-transporter 2 inhibitors on lipid profile: A systematic review and meta-analysis of 48 randomized controlled trials.

    abstract::Previous studies have suggested additional beneficial effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors including the lipid-lowering effect; however, results on lipid profile are controversial. Thus, this meta-analysis aimed to determine the effect of SGLT2 inhibitors treatment on lipid levels in patients ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sánchez-García A,Simental-Mendía M,Millán-Alanís JM,Simental-Mendía LE

    更新日期:2020-10-01 00:00:00

  • Antitumor activities and pharmacokinetics of silatecans DB-67 and DB-91.

    abstract::DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

    更新日期:2010-02-01 00:00:00

  • Destabilization of ROR1 enhances activity of Ibrutinib against chronic lymphocytic leukemia in vivo.

    abstract::Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is an onco-embryonic antigen presented on chronic lymphocytic leukemia (CLL), but not on normal adult tissues, which promotes CLL-cell survival. Here, ROR1 was identified as a new client of Heat Shock Protein 90 (HSP90) via a mass spectrometry-based screen for ROR...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Liu Z,Liu J,Zhang T,Shi M,Chen X,Chen Y,Yu J

    更新日期:2020-01-01 00:00:00

  • 6-OHDA bilateral lesions to the nucleus septi lateralis attenuate vasopressin improvement of recall in rats.

    abstract::The investigation was aimed at investigating whether the dopaminergic projection arriving at the nucleus septi lateralis (NSL) is involved in the facilitatory effect of vasopressin (AVP) on memory retrieval. The bilateral 6-OHDA lesions to the NSL were made in 20 male Wistar rats before testing the intracerebroventric...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Winnicka MM,Wiśniewski K

    更新日期:1998-02-01 00:00:00

  • Effects of acetylbergenin against D -galactosamine-induced hepatotoxicity in rats.

    abstract::The hepatoprotective effects of acetylbergenin were examined against D -galactosamine (GalN)-induced liver damage in rats, compared with that of bergenin reported previously. Acetylbergenin was synthesized from acetylation of bergenin, isolated from Mallotus japonicus, to increase lipophilic and physiological activiti...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lim HK,Kim HS,Choi HS,Oh S,Jang CG,Choi J,Kim SH,Chang MJ

    更新日期:2000-11-01 00:00:00

  • Protective effect of ginsenoside Rg5 against kidney injury via inhibition of NLRP3 inflammasome activation and the MAPK signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.

    abstract::Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhu Y,Zhu C,Yang H,Deng J,Fan D

    更新日期:2020-05-01 00:00:00

  • Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities.

    abstract::A novel alkynylthiophene series of cannabinoid CB1 receptor antagonists has been described to exhibit distinct intrinsic activities with minimal substructure modifications. The three representatives, BPR0432, BPR0568 and BPR0569, functioning as a neutral antagonist, an inverse agonist and a partial agonist, respective...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lin Y,Shia KS,Hsiao WC,Hsieh WP,Yeh TK,Tseng SL,Hsu CY,Chao YS,Hung MS

    更新日期:2010-10-01 00:00:00

  • Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice.

    abstract::Tachykinins are important in the development of pulmonary inflammation in mice but the tachykinin receptor subtype mediating this response has not been defined. To elucidate the role of tachykinin NK3-receptors on allergen-induced pulmonary inflammation, studies were performed on ovalbumin (OVA) sensitized and challen...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kung TT,Crawley Y,Jones H,Luo B,Gilchrest H,Greenfeder S,Anthes JC,Lira S,Wiekowski M,Cook DN,Hey JA,Egan RW,Chapman RW

    更新日期:2004-12-01 00:00:00

  • Dementia of Alzheimer's disease and other neurodegenerative disorders--memantine, a new hope.

    abstract::Alzheimer's disease is the fourth largest cause of death for people over 65 years of age. Dementia of Alzheimer's type is the commonest form of dementia, the other two forms being vascular dementia and mixed dementia. At present, the therapy of Alzheimer's disease is aimed at improving both, cognitive and behavioural ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Sonkusare SK,Kaul CL,Ramarao P

    更新日期:2005-01-01 00:00:00

  • Alzheimer's disease: Key developments support promising perspectives for therapy.

    abstract::Alzheimer's is the neurodegenerative disease affecting the largest number of patients in the world. In spite of the intense research of the last decades, progress about its knowledge and therapy was limited. In particular, various cytotoxic processes remained debated, while the few drugs approved for therapy were of o...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Meldolesi J

    更新日期:2019-08-01 00:00:00

  • Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart.

    abstract::Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

    更新日期:1999-08-01 00:00:00

  • Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications.

    abstract::Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In th...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Genario R,Cipolla-Neto J,Bueno AA,Santos HO

    更新日期:2021-01-01 00:00:00

  • Nicotinamide-rich diet protects the heart against ischaemia-reperfusion in mice: a crucial role for cardiac SUR2A.

    abstract::It is a consensus view that a strategy to increase heart resistance to ischaemia-reperfusion is a warranted. Here, based on our previous study, we have hypothesized that a nicotinamide-rich diet could increase myocardial resistance to ischaemia-reperfusion. Therefore, the purpose of this study was to determine whether...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Sukhodub A,Du Q,Jovanović S,Jovanović A

    更新日期:2010-06-01 00:00:00

  • Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.

    abstract::The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Koksel O,Yildirim C,Cinel L,Tamer L,Ozdulger A,Bastürk M,Degirmenci U,Kanik A,Cinel I

    更新日期:2005-05-01 00:00:00

  • An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines.

    abstract::Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety of cancer cell lines. The objective of this study was to determine the inhibitory effects of gossypol on cell proliferation. Five human carcinoma cell lines were evaluated including endometrial (RL95-2), ovarian (SKOV-3), me...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Le Blanc M,Russo J,Kudelka AP,Smith JA

    更新日期:2002-12-01 00:00:00

  • Bisoprolol and hydrochlorothiazide effects on cardiovascular remodeling in spontaneously hypertensive rats.

    abstract::Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mougenot N,Médiani O,Lechat P

    更新日期:2005-04-01 00:00:00

  • Mitochondrial quality orchestrates muscle-adipose dialog to alleviate dietary obesity.

    abstract::Skeletal muscle fitness is vital for human health and disease and is determined by the capacity for burning fuel, mitochondrial ATP production, and contraction. High quality mitochondria in skeletal muscle are essential for maintaining energy homeostasis in response to a myriad of physiologic or pathophysiological str...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Xu Z,Fu T,Guo Q,Sun W,Gan Z

    更新日期:2019-03-01 00:00:00

  • Involvement of the GABAA receptor α subunit in the mode of action of etifoxine.

    abstract::Etifoxine (EFX) is a non-benzodiazepine psychoactive drug which exhibits anxiolytic effects through a dual mechanism, by directly binding to GABAA receptors (GABAARs) and to the mitochondrial 18-kDa translocator protein, resulting in the potentiation of the GABAergic function. The β subunit subtype plays a key role in...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mattei C,Taly A,Soualah Z,Saulais O,Henrion D,Guérineau NC,Verleye M,Legros C

    更新日期:2019-07-01 00:00:00