Therapeutic effects of I(f) blockade: evidence and perspective.

abstract：:We aimed to elucidate the role of vitamin D supplementation on adipokines through a systematic review and a meta-analysis of randomized placebo-controlled trials (RCTs). The search included PUBMED, Scopus, Web of Science and Google Scholar through July 1st, 2015. Finally we identified 9 RCTs and 484 participants. Meta...

journal_title：Pharmacological research

authors： Dinca M,Serban MC,Sahebkar A,Mikhailidis DP,Toth PP,Martin SS,Blaha MJ,Blüher M,Gurban C,Penson P,Michos ED,Hernandez AV,Jones SR,Banach M,for Lipid Blood Pressure Meta-analysis Collaboration LBPMC Group.

更新日期：2016-05-01 00:00:00

abstract：:Changes in vascular responsiveness are the basis for some of the cardiovascular complications in cholestasis. Since the duration of cholestasis is important in determining the degree of the complications, we investigated the time-course dependent evolution of vascular relaxation responsiveness in the aortic rings of c...

journal_title：Pharmacological research

authors： Rastegar H,Jorjani M,Roushanzamir F,Ahmadiani A,Namiranian K,Dehpour AR

更新日期：2001-12-01 00:00:00

abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

journal_title：Pharmacological research

authors： Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

更新日期：2000-01-01 00:00:00

abstract：:Secretion of matrix metalloproteinases (MMPs) by macrophages and smooth muscle cells (SMC) may impair atherosclerotic cap integrity leading to atherosclerosis complications. Selective estrogen receptor modulators (SERMs) have favourable impact on plasma lipid levels, but their role in the prevention of atherosclerosis...

journal_title：Pharmacological research

authors： Bellosta S,Baetta R,Canavesi M,Comparato C,Granata A,Monetti M,Cairoli F,Eberini I,Puglisi L,Corsini A

更新日期：2007-08-01 00:00:00

abstract：:Breast cancer is a leading cause of morbidity and mortality in women. Both Epidemiological and experimental studies indicate a positive correlation between alcohol consumption and the risk of breast cancer. While alcohol exposure may promote the carcinogenesis or onset of breast cancer, it may as well enhance the prog...

journal_title：Pharmacological research

authors： Wang Y,Xu M,Ke ZJ,Luo J

更新日期：2017-01-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:Flibanserin has been reported to be an agonist at 5-HT1A-receptors and an antagonist at 5-HT2A receptors, with higher affinity for 5-HT1A receptors. Despite the fact that less receptor occupation is required by full agonists than by antagonists to exert their effects, flibanserin was shown to exert 5-HT2A antagonism a...

journal_title：Pharmacological research

authors： Scandroglio A,Monferini E,Borsini F

更新日期：2001-02-01 00:00:00

abstract：:"Funny" (f) channels underlie the cardiac "pacemaker"I(f) current, originally described as an inward current activated on hyperpolarization to the diastolic range of voltages in sino-atrial node myocytes [Brown, HF, DiFrancesco, D, Noble, SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236]. The invo...

journal_title：Pharmacological research

authors： DiFrancesco D

更新日期：2006-05-01 00:00:00

abstract：AIM:Acute myocardial infarction and subsequent post-infarction heart failure are among the leading causes of mortality worldwide. The endocannabinoid system has emerged as an important modulator of cardiovascular disease, however the role of endocannabinoid metabolic enzymes in heart failure is still elusive. Herein, w...

journal_title：Pharmacological research

authors： van Esbroeck ACM,Varga ZV,Di X,van Rooden EJ,Tóth VE,Onódi Z,Kuśmierczyk M,Leszek P,Ferdinandy P,Hankemeier T,van der Stelt M,Pacher P

更新日期：2020-01-01 00:00:00

abstract：:In the present study the effect of ketamine on the contractions caused by propoxur and phoxim on the isolated guinea pig ileum was investigated. Ketamine was found able to inhibit in a concentration-dependent manner the contractile responses of the ileum to propoxur and phoxim, while it did not significantly modify th...

journal_title：Pharmacological research

authors： Koutsoviti-Papadopoulou M,Kounenis G,Elezoglou V

更新日期：1994-08-01 00:00:00

abstract：:Diabetic erectile dysfunction (DED) hugely affected the patients' sexual life quality. However, there are no satisfactory therapeutic methods and intervention targets for this subtype of erectile dysfunction (ED). Inspired by the clinical practice of traditional Chinese medicine (TCM), we found that hirudin, the main ...

journal_title：Pharmacological research

authors： Yang R,Liu C,Li Q,Wang W,Wu B,Chen A,Wang B,Li W,Chen J

更新日期：2021-01-01 00:00:00

abstract：:We aimed to examine the effects of KTO-7924 (beta3-adrenoceptor agonist) on lipid metabolism and mRNA expressions in retroperitoneal white adipose tissue (RP WAT) in obese (fa/fa) Zucker rats using DNA microarray. Oral KTO-7924 for 28 days significantly decreased RP WAT weight, plasma triglyceride, free fatty acid, an...

journal_title：Pharmacological research

authors： Oana F,Homma T,Takeda H,Matsuzawa A,Akahane S,Isaji M,Akahane M

更新日期：2005-11-01 00:00:00

abstract：:Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

journal_title：Pharmacological research

authors： Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

更新日期：2000-07-01 00:00:00

abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...

journal_title：Pharmacological research

authors： Misirkic M,Janjetovic K,Vucicevic L,Tovilovic G,Ristic B,Vilimanovich U,Harhaji-Trajkovic L,Sumarac-Dumanovic M,Micic D,Bumbasirevic V,Trajkovic V

更新日期：2012-01-01 00:00:00

abstract：:Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

journal_title：Pharmacological research

authors： Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

更新日期：2017-03-01 00:00:00

abstract：:Long non-coding RNA (lncRNA) is a class of non-coding RNA with ≥200 nucleotides in length which are involved as critical regulators in various cellular processes. LncRNAs contribute to the development and progression of many human diseases. Autophagy is a key catabolic process which helps to maintain the cellular home...

journal_title：Pharmacological research

authors： Barangi S,Hayes AW,Reiter R,Karimi G

更新日期：2019-04-01 00:00:00

abstract：:The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

journal_title：Pharmacological research

authors： Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

更新日期：1999-11-01 00:00:00

abstract：:Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and medicinal plants. In the last decade, a plethora of studies on the pharmacological activities of lupeol have been conducted and have demonstrated that lupeol possesses an extensive range of pharmacological activities such as antic...

journal_title：Pharmacological research

authors： Liu K,Zhang X,Xie L,Deng M,Chen H,Song J,Long J,Li X,Luo J

更新日期：2020-12-11 00:00:00

abstract：:We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) is a salt form of niclosamide and has ...

journal_title：Pharmacological research

authors： Li SL,Yan J,Zhang YQ,Zhen CL,Liu MY,Jin J,Gao JL,Xiao XL,Shen X,Tai Y,Hu N,Zhang XZ,Sun ZJ,Dong DL

更新日期：2017-01-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

journal_title：Pharmacological research

authors： Shimomura Y,Kitaura Y

更新日期：2018-07-01 00:00:00

abstract：:Pre-eclampsia (PE) is a complication of pregnancy that is associated with mortality and morbidity in mothers and fetuses worldwide. Oxygen dysregulation in the placenta, abnormal remodeling of the spiral artery, defective placentation, oxidative stress at the fetal-maternal border, inflammation and angiogenic impairme...

journal_title：Pharmacological research

authors： Ahmadian E,Rahbar Saadat Y,Hosseiniyan Khatibi SM,Nariman-Saleh-Fam Z,Bastami M,Zununi Vahed F,Ardalan M,Zununi Vahed S

更新日期：2020-05-01 00:00:00

abstract：:Despite our insufficient understanding of the exact molecular mechanisms of general anesthetics and sedatives, every year millions of children are treated with these drugs in a seemingly safe manner. However, increasing evidence particularly from animal studies has suggested the possibility for deleterious effects in ...

journal_title：Pharmacological research

authors： Ward CG,Loepke AW

更新日期：2012-03-01 00:00:00

abstract：:The uridin-diphosphoglucuronyl-transferase (UDP-GT) is a membrane-bound enzyme responsible for glucuronidation of endogenous and exogenous compounds. This work established the UDP-GT activity and its lipid membrane microenvironment in two experimental models: acute paracetamol intoxication, and cholestasis followed by...

journal_title：Pharmacological research

authors： Bengochea L,Ghanem C,Perazzo JC,Ghisolfi C,Marabotto L,Acevedo C,Mino J,Lemberg A,Rubio M

更新日期：1999-10-01 00:00:00

abstract：:This article summarizes the discovery and the development of endothelial biology with a special focus on the role of endothelium-dependent vasoconstriction. The physician-scientist Paul Michel Vanhoutte contributed many of the initial observations that helped to understand and form the main concepts of modern vascular...

journal_title：Pharmacological research

authors： Barton M

更新日期：2011-06-01 00:00:00

abstract：INTRODUCTION:Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the func...

journal_title：Pharmacological research

authors： Silva DF,Wenceslau CF,Mccarthy CG,Szasz T,Ogbi S,Webb RC

更新日期：2019-09-01 00:00:00

abstract：:In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study,we introduced the current ...

journal_title：Pharmacological research

authors： Wu W,Tang Z,Chen J,Gao Y

更新日期：2019-10-01 00:00:00

abstract：:Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of pulmonary function, rapidly leading to death. While its clinical role as an anticancer agent is limited, its use in experimental settings is...

journal_title：Pharmacological research

authors： Della Latta V,Cecchettini A,Del Ry S,Morales MA

更新日期：2015-07-01 00:00:00

abstract：:Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...

journal_title：Pharmacological research

authors： Bourre L,Thibaut S,Briffaud A,Lajat Y,Patrice T

更新日期：2002-02-01 00:00:00

abstract：:There is evidence that hydrazine, a metabolite of isoniazid, plays an important role in the mechanism of isoniazid-induced hepatotoxicity. Hydrazine has been reported to be metabolised by NADPH cytochrome P-450 reductase (reductase) to reactive and potentially toxic intermediates. The present study was designed, using...

journal_title：Pharmacological research

authors： Sarich TC,Adams SP,Wright JM

更新日期：1998-09-01 00:00:00

abstract：:Alzheimer's is the neurodegenerative disease affecting the largest number of patients in the world. In spite of the intense research of the last decades, progress about its knowledge and therapy was limited. In particular, various cytotoxic processes remained debated, while the few drugs approved for therapy were of o...

journal_title：Pharmacological research

authors： Meldolesi J

更新日期：2019-08-01 00:00:00