Abstract:
:Alzheimer's is the neurodegenerative disease affecting the largest number of patients in the world. In spite of the intense research of the last decades, progress about its knowledge and therapy was limited. In particular, various cytotoxic processes remained debated, while the few drugs approved for therapy were of only marginal relevance. Recent studies have identified key aspects of the disease, such as the mechanisms governing the development of pathology. In order to operate the Aβ peptide, known as the key factor, requires a complex assembled by its high affinity binding to PrPc, a cell surface prion protein, and mGluR5, a metabotropic glutamate receptor. Aβ and its associates bind also phosphorylated tau transferred to the extracellular space, with final activation of intracellular cytotoxic signals. Pathology is further affected by factors (including genes, receptors and their agonists) and by glial cells governing (via vesicles, cytokines and enzymes) cell immunology, inflammation and oxidative stress. Concomitant to pathology studies, strong attempts have been made for the development of new, effective therapies. Critical for this are biomarkers, by which Alzheimer's patients are recognized even before appearance of their symptoms. The question was whether patients take advantage from drugs not yet approved. The latter, first identified in mice, were found effective also in men, however only before appearance or at early stage of the disease. In other words, the drugs not yet approved induce effective protection of patients still healthy or in a preliminary stage of the disease. In contrast, developed Alzheimer's disease is practically irreversible.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Meldolesi Jdoi
10.1016/j.phrs.2019.104316subject
Has Abstractpub_date
2019-08-01 00:00:00pages
104316eissn
1043-6618issn
1096-1186pii
S1043-6618(19)30601-2journal_volume
146pub_type
杂志文章,评审abstract::A growing number of evidences from clinical and preclinical studies have shown that dysregulation of microRNA (miRNA) function contributes to the progression of cancer and thus miRNA can be an effective target in therapy. Dietary phytochemicals, such as quercetin, are natural products that have potential anti-cancer p...
journal_title:Pharmacological research
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abstract::A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...
journal_title:Pharmacological research
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doi:10.1006/phrs.1998.0379
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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doi:10.1016/j.phrs.2004.02.008
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journal_title:Pharmacological research
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doi:10.1016/1043-6618(90)90754-2
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2003.11.017
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2016.11.008
更新日期:2017-01-01 00:00:00
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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doi:10.1016/j.phrs.2016.09.006
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更新日期:2019-07-01 00:00:00
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journal_title:Pharmacological research
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更新日期:2021-01-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/j.phrs.2015.05.001
更新日期:2015-09-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1016/j.phrs.2005.05.014
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journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:1996-04-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Pharmacological research
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
doi:10.1016/1043-6618(90)90739-z
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