Abstract:
:Flibanserin has been reported to be an agonist at 5-HT1A-receptors and an antagonist at 5-HT2A receptors, with higher affinity for 5-HT1A receptors. Despite the fact that less receptor occupation is required by full agonists than by antagonists to exert their effects, flibanserin was shown to exert 5-HT2A antagonism at doses (4-5 mg kg-1) that are lower or equal to those required to stimulate 5-HT1A receptors. In order to understand this phenomenon, the interaction of flibanserin with 5-HT1A and 5-HT2A receptors was evaluated in ex vivo binding studies. This interaction was evaluated in the prefrontal cortex, hippocampus and midbrain by using [3H]8-OH-DPAT and [3H]ketanserin to label 5-HT1A and 5-HT2A receptors, respectively. Flibanserin was given at 1, 10 and 30 mg kg-1 intraperitoneally. The dose of 1 mg kg-1 displaced both radioligands preferentially in the frontal cortex. The doses of 10 and 30 mg kg-1 reduced the binding of both radioligands in all the three brain regions non-selectively by about 50% and 70%, respectively. The displacement was maximal after 0.5 h and was reduced or not evident after 3 h. We conclude that 5-HT2 antagonism brought about by low doses of flibanserin may reflect functional mechanisms more than receptor-mediated effects.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Scandroglio A,Monferini E,Borsini Fdoi
10.1006/phrs.2000.0762keywords:
subject
Has Abstractpub_date
2001-02-01 00:00:00pages
179-83issue
2eissn
1043-6618issn
1096-1186pii
S1043-6618(00)90762-Xjournal_volume
43pub_type
杂志文章abstract:OBJECTIVE:The vasorelaxant effect of 2-arachidonoylglycerol (2-AG) has been well characterised in animals. 2-AG is present in human vascular cells and is up-regulated in cardiovascular pathophysiology. However, the acute vascular actions of 2-AG have not been explored in humans. APPROACH:Mesenteric arteries were obtai...
journal_title:Pharmacological research
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journal_title:Pharmacological research
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pub_type: 杂志文章,随机对照试验
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journal_title:Pharmacological research
pub_type: 杂志文章
doi:10.1006/phrs.1998.0442
更新日期:1999-04-01 00:00:00
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doi:10.1016/j.phrs.2014.02.008
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journal_title:Pharmacological research
pub_type: 杂志文章
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更新日期:1997-05-01 00:00:00
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journal_title:Pharmacological research
pub_type: 杂志文章,评审
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