EEG and behavioural effects of polyamines (spermine and spermidine) on rabbits.

abstract：:The intestinal barrier function depends on an adequate response to pathogens by the epithelium. Toll-like receptor 3 (TLR-3) recognizes double-stranded RNA, a virus-associated molecular pattern. Activation of TLR-3 with Poly(I:C), a synthetic agonist, modulates tissue repair and permeability in other epithelia; howeve...

journal_title：Pharmacological research

authors： Moyano-Porcile V,Olavarría-Ramírez L,González-Arancibia C,Bravo JA,Julio-Pieper M

更新日期：2015-11-01 00:00:00

abstract：:Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggest that statins have additional properties such as endothelial protection via action o...

journal_title：Pharmacological research

authors： Malfitano AM,Marasco G,Proto MC,Laezza C,Gazzerro P,Bifulco M

更新日期：2014-10-01 00:00:00

abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

journal_title：Pharmacological research

authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

更新日期：2007-12-01 00:00:00

abstract：:In the present study, we have investigated the effects of centrally administered ginsenoside Rc and Rg1 on the modulation of the NMDA receptor and GABA(A)receptor binding in rat brain. The NMDA receptor binding was analysed by quantitative autoradiography using [(3)H]MK-801 binding, and the GABA(A)receptor bindings we...

journal_title：Pharmacological research

authors： Kim HS,Hwang SL,Nah SY,Oh S

更新日期：2001-05-01 00:00:00

abstract：:The antinociceptive and motor effects of the hydrophilic alpha 2-adrenoceptor agonist ST-91 were studied after intrathecal administration to male Wistar rats in different heat-pain tests and different test settings. Intrathecal administration of ST-91 caused a dose-dependent increase in hind paw licking latency in the...

journal_title：Pharmacological research

authors： Horváth G,Dobos I,Liszli P,Klimscha W,Szikszay M,Benedek G

更新日期：1997-06-01 00:00:00

abstract：:An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

journal_title：Pharmacological research

authors： Giacobini E

更新日期：2004-10-01 00:00:00

abstract：:Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. In visceral obese subjects, signal transducer and activator of the transcription 3 (STAT3) in adipocy...

journal_title：Pharmacological research

authors： Su T,Huang C,Yang C,Jiang T,Su J,Chen M,Fatima S,Gong R,Hu X,Bian Z,Liu Z,Kwan HY

更新日期：2020-02-01 00:00:00

abstract：:Iron is an essential element for virtually all organisms. It facilitates cell proliferation and growth but also contributes to major hallmarks of cancer such as tumor initiation, growth, and metastasis. Often, iron handling of tumor cells is disturbed, with altered iron acquisition, efflux, and storage. Targeting pert...

journal_title：Pharmacological research

authors： Jung M,Mertens C,Bauer R,Rehwald C,Brüne B

更新日期：2017-06-01 00:00:00

abstract：:Kidney injury is one of the main complications of obstructive jaundice (OJ) and its pathogenesis has not been clarified. As an independent risk factor for OJ associated with significant morbidity and mortality, it can be mainly divided into two types of morphological injury and functional injury. We called these dysfu...

journal_title：Pharmacological research

authors： Liu J,Qu J,Chen H,Ge P,Jiang Y,Xu C,Chen H,Shang D,Zhang G

更新日期：2021-01-01 00:00:00

abstract：:Selective cyclooxygenase 2 (COX2) inhibitors (COXIBs) are effective anti-inflammatory and analgesic drugs with improved gastrointestinal (GI) safety compared to nonselective nonsteroidal anti-inflammatory drugs known as traditional (tNSAIDs). However, their use is associated with a cardiovascular (CV) hazard (i.e. inc...

journal_title：Pharmacological research

authors： Martelli A,Testai L,Anzini M,Cappelli A,Di Capua A,Biava M,Poce G,Consalvi S,Giordani A,Caselli G,Rovati L,Ghelardini C,Patrignani P,Sautebin L,Breschi MC,Calderone V

更新日期：2013-12-01 00:00:00

abstract：:Although calcimimetics were developed to block parathyroid hormone synthesis, some reports suggest that they may also reduce blood pressure by unknown mechanisms. Calcimimetic-induced changes in the synthesis of endothelial vasoactive factors could be involved. Wistar rats were treated with the calcimimetic R-568, and...

journal_title：Pharmacological research

authors： Martínez-Miguel P,Medrano-Andrés D,Lopes-Martín V,Arribas-Gómez I,Rodríguez-Puyol M,Rodríguez-Puyol D,López-Ongil S

更新日期：2013-10-01 00:00:00

abstract：:The Janus kinase (JAK) family of non-receptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (tyrosine kinase-2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that regulates the adjacent protein kinase domain (JH1). JAK1/2 and TYK2 are ubiquitously expressed whereas JAK3 is...

journal_title：Pharmacological research

authors： Roskoski R Jr

更新日期：2016-09-01 00:00:00

abstract：:The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...

journal_title：Pharmacological research

authors： Arzi A,Hemmati AA,Razian A

更新日期：2004-03-01 00:00:00

abstract：:CYT387 is an orally bioavailable, small molecule inhibitor of Janus family of tyrosine kinases (JAK) 1 and 2. It is currently undergoing Phase I/II clinical trials for the treatment of myelofibrosis and myeloproliferative neoplasms. We aimed to establish whether the multidrug efflux transporters P-glycoprotein (P-gp; ...

journal_title：Pharmacological research

authors： Durmus S,Xu N,Sparidans RW,Wagenaar E,Beijnen JH,Schinkel AH

更新日期：2013-10-01 00:00:00

abstract：:In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sen...

journal_title：Pharmacological research

authors： Kounenis G,Koutsoviti-Papadopoulou M,Elezoglou V

更新日期：1995-06-01 00:00:00

abstract：:Alzheimer's is the neurodegenerative disease affecting the largest number of patients in the world. In spite of the intense research of the last decades, progress about its knowledge and therapy was limited. In particular, various cytotoxic processes remained debated, while the few drugs approved for therapy were of o...

journal_title：Pharmacological research

authors： Meldolesi J

更新日期：2019-08-01 00:00:00

abstract：:Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject of increasing attention. Boldine, in particular, the major and most characteristic alkaloidal con...

journal_title：Pharmacological research

authors： Speisky H,Cassels BK

更新日期：1994-01-01 00:00:00

abstract：CONTEXT:Ticagrelor was related to bradycardia in DISPERSE-II trial. This risk has been integrated into the European risk-management plan, and its use is warned in at-risk patients. Nevertheless, this risk was not systematically assessed nor measured. OBJECTIVES:To estimate the risk of bradyarrhythmia associated with t...

journal_title：Pharmacological research

authors： Pujade I,Perino J,Mathieu C,Arnaud M,Raschi E,Gatti M,Bezin J,Salvo F

更新日期：2020-10-01 00:00:00

abstract：:We aimed to investigate the cardiac changes in patients with human epidermal growth factor receptor 2 (HER2)-positive breast cancer treated with trastuzumab in an adjuvant setting. Two hundred and fifty-three women with HER2-positive breast cancer were included. The assessment of cardiovascular system and echocardiogr...

journal_title：Pharmacological research

authors： Piotrowski G,Gawor R,Bourge RC,Stasiak A,Potemski P,Gawor Z,Nanda NC,Banach M

更新日期：2013-12-01 00:00:00

abstract：:The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and ac...

journal_title：Pharmacological research

authors： Cinelli M,Magnelli L,Chiarugi V

更新日期：1998-02-01 00:00:00

abstract：:The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening the cytoskeleton of ASM. Although the underlying mechanism is not entirely cle...

journal_title：Pharmacological research

authors： Wang L,Chitano P,Seow CY

更新日期：2020-09-01 00:00:00

abstract：:Inflammatory reaction and cell apoptosis are two important processes in intestinal ischemia/reperfusion (II/R) injury, and exploration of effective lead compounds against II/R injury via regulating inflammation and apoptosis is critical important. In this paper, the results indicated that dioscin significantly increas...

journal_title：Pharmacological research

authors： Zheng L,Han X,Hu Y,Zhao X,Yin L,Xu L,Qi Y,Xu Y,Han X,Liu K,Peng J

更新日期：2019-01-01 00:00:00

abstract：:Advanced glycation end-products (AGE) and the receptor for AGE (RAGE) have been linked to numerous diabetic vascular complications. RAGE activation promotes a self-sustaining state of chronic inflammation and has been shown to induce apoptosis in various cell types. Although previous studies in vascular smooth muscle ...

journal_title：Pharmacological research

authors： Maltais JS,Simard E,Froehlich U,Denault JB,Gendron L,Grandbois M

更新日期：2016-02-01 00:00:00

abstract：:Though the AMPA receptor has been implicated in several neurodegenerative processes (epilepsy, ischemia, spasticity), its role in cognition is yet to be clarified. The aim of this study was to assess in the rat the effects of the AMPA receptor antagonist NBQX (3.5, 7, 10, 20 and 30 mgkg(-1), i.p.) on learning and memo...

journal_title：Pharmacological research

authors： Pitsikas N,Rigamonti AE,Cella SG,Muller EE

更新日期：2002-01-01 00:00:00

abstract：:The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this new family of molecules toward a clinical phase 1 trial, the mechanism of action governing the anticancer properties ...

journal_title：Pharmacological research

authors： Perreault M,Maltais R,Kenmogne LC,Létourneau D,LeHoux JG,Gobeil S,Poirier D

更新日期：2018-02-01 00:00:00

abstract：:To minimize irreversible brain injury after acute ischemic stroke (AIS), the time to treatment (i.e., treatment delay) should be minimized. However, thus far, all cytoprotective clinical trials have failed. Analysis of literature identified short treatment durations (≤72 h) as a common motif among completed cytoprotec...

journal_title：Pharmacological research

authors： Gaidhani N,Uteshev VV

更新日期：2018-10-01 00:00:00

abstract：:Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

journal_title：Pharmacological research

authors： Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

更新日期：2005-03-01 00:00:00

abstract：:Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of ...

journal_title：Pharmacological research

authors： Huber G,Schuster F,Raasch W

更新日期：2017-11-01 00:00:00

abstract：:Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack...

journal_title：Pharmacological research

authors： Wu T,Yu GY,Xiao J,Yan C,Kurihara H,Li YF,So KF,He RR

更新日期：2018-07-01 00:00:00

abstract：:Exposure to ionizing radiation causes damage to living tissues; however, only a small number of agents have been approved for use in radiation injuries. Radioprotector is the primary countermeasure to radiation injury and none radioprotector has indeed reached the drug development stage. Repurposing the long list of a...

journal_title：Pharmacological research

authors： Ren L,Xie D,Li P,Qu X,Zhang X,Xing Y,Zhou P,Bo X,Zhou Z,Wang S

更新日期：2016-11-01 00:00:00