Short-term effects of Poly(I:C) on gut permeability.

abstract：:Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell ...

journal_title：Pharmacological research

authors： Westermeier F,Bustamante M,Pavez M,García L,Chiong M,Ocaranza MP,Lavandero S

更新日期：2015-11-01 00:00:00

abstract：:Memory T cells can be generated and remain long-term in different tissues following infection or immunization. Tissue-resident memory T (TRM) cells are a unique group of memory T cells that form and persist mainly in peripheral non-lymphoid organs. Unlike effector or central memory T (TEM or TCM) cells, TRM cells do n...

journal_title：Pharmacological research

authors： Wang T,Shen Y,Luyten S,Yang Y,Jiang X

更新日期：2020-09-01 00:00:00

abstract：:Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present study investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial infarction given specifically at reperfusion and the signalling pathway involved. Thiobutabarb...

journal_title：Pharmacological research

authors： Karwi QG,Whiteman M,Wood ME,Torregrossa R,Baxter GF

更新日期：2016-09-01 00:00:00

abstract：:Duchenne muscular dystrophy (DMD) is a severe muscle disease of known etiology without effective, or generally applicable therapy. Mitochondria are affected by the disease in animal models but whether mitochondrial dysfunction is part of the pathogenesis in patients remains unclear. We show that primary cultures obtai...

journal_title：Pharmacological research

authors： Schiavone M,Zulian A,Menazza S,Petronilli V,Argenton F,Merlini L,Sabatelli P,Bernardi P

更新日期：2017-11-01 00:00:00

abstract：:The effect of the inhalation of vaporized ethanol on injected [1-14C]pyruvate kinetics was studied in mice. The [1-14C]pyruvate kinetics were modelled by means of a four-compartment closed model, i.e. injected site, blood, periphery and expired 14CO2. The results show that the inhalation of vaporized ethanol can stimu...

journal_title：Pharmacological research

authors： Wu G

更新日期：1998-01-01 00:00:00

abstract：:Exogenously administered fructose-1,6-diphosphate (FDP) has been studied for its ability to protect tissue during hypoxia or ischemia. Recently, a clear effect of FDP on the central nervous system has raised the question whether FDP can get into the brain. FDP levels were measured in blood, brain, liver, kidney, muscl...

journal_title：Pharmacological research

authors： Xu K,Stringer JL

更新日期：2008-03-01 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) epidemic has been almost controlled in China under a series of policies, including "early diagnosis and early treatment". This study aimed to explore the association between early treatment with Qingfei Paidu decoction (QFPDD) and favorable clinical outcomes. In this retrospecti...

journal_title：Pharmacological research

authors： Shi N,Liu B,Liang N,Ma Y,Ge Y,Yi H,Wo H,Gu H,Kuang Y,Tang S,Zhao Y,Tong L,Liu S,Zhao C,Chen R,Bai W,Fan Y,Shi Z,Li L,Liu J,Gu H,Zhi Y,Wang Z,Li Y,Li H,Wang J,Jiao L,Tian Y,Xiong Y,Huo R,Zhang X

更新日期：2020-11-01 00:00:00

abstract：:Oxidative stress is related to the progression of renal diseases and modulation of oxidative stress can lead to a reduction in vascular events in patients with chronic renal insufficiency (CRI). Indoxyl sulfate (IS) and xanthine oxidase (XO) are related to impaired neovasculogenesis in CRI. Hydralazine is suggested fo...

journal_title：Pharmacological research

authors： Chang TT,Chen JW

更新日期：2020-01-01 00:00:00

abstract：:We have recently synthesized a new series of 4,5-dihydrobenzo-oxa-cycloheptapyrazole derivatives with the aim to discover novel CB1 antagonist agents characterized by anti-obesity activity comparable to that of SR141716A but with reduced adverse effects such as anxiety and depression. Within the novel class, the CB1 a...

journal_title：Pharmacological research

authors： Mastinu A,Pira M,Pinna GA,Pisu C,Casu MA,Reali R,Marcello S,Murineddu G,Lazzari P

更新日期：2013-08-01 00:00:00

abstract：:Several factors such as proteinuria and renal fibrosis may be important in the progression of many forms of chronic renal diseases. The purposes of the current study were to investigate the progressive renal failure of the rats with surgical renal mass reduction (RMR) and the effect of the angiotensin-converting enzym...

journal_title：Pharmacological research

authors： Yatsu T,Sanagi M,Fujimori A,Tomura Y,Hayashi K,Tanahashi M,Inagaki O

更新日期：2003-03-01 00:00:00

abstract：:Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size des...

journal_title：Pharmacological research

authors： Gaborit B,Moulin PA,Bege T,Boullu S,Vincentelli C,Emungania O,Morange PE,Berdah S,Salem JE,Dutour A,Frere C

更新日期：2018-05-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer researchers have developed many agents to target TRAIL and some of these agents have entered clinical trials in oncology. Unfortunatel...

journal_title：Pharmacological research

authors： Dianat-Moghadam H,Heidarifard M,Mahari A,Shahgolzari M,Keshavarz M,Nouri M,Amoozgar Z

更新日期：2020-05-01 00:00:00

abstract：:Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...

journal_title：Pharmacological research

authors： Mansour MA,El-Kashef HA,Al-Shabanah OA

更新日期：1999-03-01 00:00:00

abstract：:Nebivolol is a new selective beta 1-adrenergic blocking agent, that possesses a peculiar pharmacodynamic profile and an original chemical structure, by which it differs from traditional beta 1-blockers. Nebivolol is a racemic mixture of two enantiomers in equal ratios. It is endowed with a highly selective beta 1-bloc...

journal_title：Pharmacological research

authors： Mangrella M,Rossi F,Fici F,Rossi F

更新日期：1998-12-01 00:00:00

abstract：:Skeletal muscle fitness is vital for human health and disease and is determined by the capacity for burning fuel, mitochondrial ATP production, and contraction. High quality mitochondria in skeletal muscle are essential for maintaining energy homeostasis in response to a myriad of physiologic or pathophysiological str...

journal_title：Pharmacological research

authors： Xu Z,Fu T,Guo Q,Sun W,Gan Z

更新日期：2019-03-01 00:00:00

abstract：:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a s...

journal_title：Pharmacological research

authors： Brites GS,Ferreira I,Sebastião AI,Silva A,Carrascal M,Neves BM,Cruz MT

更新日期：2020-12-01 00:00:00

abstract：:Baroreflex plays a crucial role in regulation of arterial blood pressure (BP). Recently, Piezo1 and Piezo2, the mechanically-activated (MA) ion channels, have been identified as baroreceptors. However, the underlying molecular mechanism for regulating these baroreceptors in hypertension remains unknown. In this study,...

journal_title：Pharmacological research

authors： Huo L,Gao Y,Zhang D,Wang S,Han Y,Men H,Yang Z,Qin X,Wang R,Kong D,Bai H,Zhang H,Zhang W,Jia Z

更新日期：2020-12-19 00:00:00

abstract：:Despite our insufficient understanding of the exact molecular mechanisms of general anesthetics and sedatives, every year millions of children are treated with these drugs in a seemingly safe manner. However, increasing evidence particularly from animal studies has suggested the possibility for deleterious effects in ...

journal_title：Pharmacological research

authors： Ward CG,Loepke AW

更新日期：2012-03-01 00:00:00

abstract：:Purine release and prostaglandin (PG) outflow were simultaneously evaluated from untreated glial primary cultures of rat striatum, at rest and under field electrical stimulation. Purine release was also assayed from sister cultured cells in which a suitable pharmacological treatment with 1 x 10(-6) M dexamethasone or ...

journal_title：Pharmacological research

authors： Caciagli F,Ciccarelli R,Di Iorio P,Tacconelli L,Ballerini P

更新日期：1989-05-01 00:00:00

abstract：:TMEM16A plays critical roles in physiological process and may serve as drug targets for diverse diseases. Recently, TMEM16A has started to be regarded as potential primary lung adenocarcinoma targets. Here, we identified that arctigenin, a natural compound, is a novel TMEM16A inhibitor, and it can suppress lung adenoc...

journal_title：Pharmacological research

authors： Guo S,Chen Y,Shi S,Wang X,Zhang H,Zhan Y,An H

更新日期：2020-05-01 00:00:00

abstract：:The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

journal_title：Pharmacological research

authors： Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

更新日期：2018-03-01 00:00:00

abstract：:Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified ...

journal_title：Pharmacological research

authors： Ramello MC,Haura EB,Abate-Daga D

更新日期：2018-03-01 00:00:00

abstract：:Cardiac arrhythmia can be a serious complication during general anaesthesia of patients suffering from cardiac arrhythmias and using antiarrhythmic drugs. The aim of the present experiments was to establish the way in which lidocaine and verapamil influence haemodynamic parameters of rabbits after midazolam anaesthesi...

journal_title：Pharmacological research

authors： Wiktorowska A,Owczarek J,Orszulak-Michalak D

更新日期：1999-06-01 00:00:00

abstract：:The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faec...

journal_title：Pharmacological research

authors： Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

更新日期：1993-01-01 00:00:00

abstract：:Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our...

journal_title：Pharmacological research

authors： Liu J,Yue S,Yang Z,Feng W,Meng X,Wang A,Peng C,Wang C,Yan D

更新日期：2018-08-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

journal_title：Pharmacological research

authors： Zhu Y,Zhu C,Yang H,Deng J,Fan D

更新日期：2020-05-01 00:00:00

abstract：:In recent years, natural products have reemerged as biotherapeutic options, with several dietary carotenoids, viz. astaxanthin, fucoxanthin, siphonaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene, developing as potential candidates for chemoprevention and chemotherapeutics of breast, colorectal, lung, a...

journal_title：Pharmacological research

authors： Saini RK,Keum YS,Daglia M,Rengasamy KR

更新日期：2020-07-01 00:00:00

abstract：:Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...

journal_title：Pharmacological research

authors： Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

更新日期：2001-03-01 00:00:00

abstract：:Bombycis corpus(BC) or Bombyx Batryticatus, a batryticated silkworm and white-stiff silkworm, is a drug consisting of the dried larva of silkworm, Mobyz mori L., dead and stiffened due to the infection of Beauveria (Bals.) Vuill. In the present study, we have examined the protective effect of the water extracts agains...

journal_title：Pharmacological research

authors： Kim HJ,Lee WH,Yoon CH,Jeong JC,Nam KS,Kim HM,Choo YK,Lee MC,Kim CH

更新日期：2001-01-01 00:00:00

abstract：:Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg(-1)day(-1)for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a ...

journal_title：Pharmacological research

authors： Ali BH,Al-Qarawi AA

更新日期：2000-07-01 00:00:00