当前位置： SCI文献检索 > PHARMACOLOGICAL RESEARCH期刊下所有文献 > Progression of renal failure with anaemia and multiple effects of angiotensin-converting enzyme inhibitor in rats with renal mass reduction.

Progression of renal failure with anaemia and multiple effects of angiotensin-converting enzyme inhibitor in rats with renal mass reduction.

Abstract：

:Several factors such as proteinuria and renal fibrosis may be important in the progression of many forms of chronic renal diseases. The purposes of the current study were to investigate the progressive renal failure of the rats with surgical renal mass reduction (RMR) and the effect of the angiotensin-converting enzyme (ACE) inhibitor, lisinopril, and to document correlation of several factors associated with progressive renal failure. Rats were subtotal (5/6) nephrectomized by resection of the renal poles and sham-operated. The functional, histological and haematological changes of the rats were studied for up to 10 weeks. After 2 weeks of RMR, oral administration of lisinopril (10 mg kg(-1) per day) was performed for 8 weeks. RMR resulted in progressive renal failure with proteinuria, monocyte/macrophage (ED1+) infiltration, anaemia as assessed by haemoglobin and haematocrit (Htc), renal hypertrophy as assessed by left kidney to body weight ratio (BKW/BW), and renal fibrosis as assessed by glomerular lesions and tubulointerstitial changes. Lisinopril exhibited renoprotection with antiproteinuric effect and inhibition of monocyte/macrophage (ED1+) infiltration. However, beneficial effect of lisinopril on anaemia was not observed. At 10 weeks after surgery, severity of proteinuria positively correlated with plasma creatinine (Pcr), BKW/BW, histological damage, and systolic blood pressure, and negatively correlated with haemoglobin. Severity of tubulointerstitial changes positively correlated with Pcr and blood urea nitrogen, and negatively correlated with haemoglobin and Htc. Moreover, monocyte/macrophage (ED1+) infiltration positively correlated with severity of proteinuria and tubulointerstitial changes. These findings strongly support that proteinuria, monocyte/macrophage infiltration and renal fibrosis appear to play principal roles in the progressive renal failure with anaemia and renoprotection of ACE inhibition may be mediated by multiple actions of ACE inhibitor. The present study confirms that rats with RMR is useful to explore target molecules for renoprotective drugs and evaluate renoprotective effect of new molecular entities.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Yatsu T,Sanagi M,Fujimori A,Tomura Y,Hayashi K,Tanahashi M,Inagaki O

doi

10.1016/s1043-6618(02)00321-3

keywords:

subject

Has Abstract

pub_date

2003-03-01 00:00:00

pages

243-52

issue

3

eissn

1043-6618

issn

1096-1186

pii

S1043661802003213

journal_volume

47

pub_type

杂志文章

相关文献

PHARMACOLOGICAL RESEARCH文献大全
  • Levosulpiride: a review of its clinical use in psychiatry.

    abstract：:Levosulpiride is the (-)-enantiomer of sulpiride. It has shown greater central antidopaminergic activity, antiemetic and antidyspeptic effects and lower acute toxicity than both the racemic and dextro forms. Several clinical studies indicate that levosulpiride has therapeutic efficacy in depressive and somatoform diso...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/1043-6618(95)80053-0

    authors： Mucci A,Nolfe G,Maj M

    更新日期：1995-02-01 00:00:00

  • Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression.

    abstract：:The suppression of the abnormal systemic immune response constitutes a primary strategy for treatment of rheumatoid arthritis (RA); toward this end, the identification of natural compounds with immunosuppressive activity represents a promising strategy for RA drug discovery. Cinnamtannin D1 (CTD-1), a polyphenolic com...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2019.104513

    authors： Shi C,Zhang H,Wang X,Jin B,Jia Q,Li Y,Yang Y

    更新日期：2020-01-01 00:00:00

  • Investigation of cancer drug resistance mechanisms by phosphoproteomics.

    abstract：:Cancer cell mutations can be identified by genomic and transcriptomic techniques. However, they are not sufficient to understand the full complexity of cancer heterogeneity. Analyses of proteins expressed in cancers and their modification profiles show how these mutations could be translated at the functional level. P...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2020.105091

    authors： Boulos JC,Yousof Idres MR,Efferth T

    更新日期：2020-10-01 00:00:00

  • Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis.

    abstract：:Cetyl myristoleate (CM) was reported by Diehl and May [J Pharm Sci 83 (1994) 296] to block inflammation and prevent adjuvant-induced arthritis in rats. To verify this earlier work, we have synthesized pure CM and tested its anti-arthritic properties in a collagen-induced arthritis model in DBA/1LacJ mice. Multiple int...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/s1043-6618(02)00239-6

    authors： Hunter KW Jr,Gault RA,Stehouwer JS,Tam-Chang SW

    更新日期：2003-01-01 00:00:00

  • Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.

    abstract：:Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present study investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial infarction given specifically at reperfusion and the signalling pathway involved. Thiobutabarb...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2016.06.028

    authors： Karwi QG,Whiteman M,Wood ME,Torregrossa R,Baxter GF

    更新日期：2016-09-01 00:00:00

  • The non-NMDA receptor antagonist NBQX does not affect rats performance in the object recognition task.

    abstract：:Though the AMPA receptor has been implicated in several neurodegenerative processes (epilepsy, ischemia, spasticity), its role in cognition is yet to be clarified. The aim of this study was to assess in the rat the effects of the AMPA receptor antagonist NBQX (3.5, 7, 10, 20 and 30 mgkg(-1), i.p.) on learning and memo...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.2001.0898

    authors： Pitsikas N,Rigamonti AE,Cella SG,Muller EE

    更新日期：2002-01-01 00:00:00

  • Direct inotropic effects of propofol and adenosine on rat atrial muscle: possible mechanisms.

    abstract：:Experiments were designed to evaluate the mechanisms of propofol and adenosine in rat atrial muscle. Atria were suspended in the isolated organ bath system for isometric tension recording and response to propofol and adenosine were tested in the absence and presence of glibenclamide, N(G)-nitro-arginine-methyl-ester (...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.2000.0666

    authors： Cinel I,Gür S

    更新日期：2000-08-01 00:00:00

  • Gentamicin-induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it?

    abstract：:Aminoglycoside antibiotics are employed clinically because of their potent bactericidal activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs belong to this class are well-known to cause nephrotoxicity, which limits their frequent clinical exploitation. Gentamicin, a commonly used...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2010.04.004

    authors： Balakumar P,Rohilla A,Thangathirupathi A

    更新日期：2010-09-01 00:00:00

  • GDF-11 prevents cardiomyocyte hypertrophy by maintaining the sarcoplasmic reticulum-mitochondria communication.

    abstract：:Growth differentiation factor 11 (GDF11) is a novel factor with controversial effects on cardiac hypertrophy both in vivo and in vitro. Although recent evidence has corroborated that GDF11 prevents the development of cardiac hypertrophy, its molecular mechanism remains unclear. In our previous work, we showed that nor...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2019.104273

    authors： Garrido-Moreno V,Díaz-Vegas A,López-Crisosto C,Troncoso MF,Navarro-Marquez M,García L,Estrada M,Cifuentes M,Lavandero S

    更新日期：2019-08-01 00:00:00

  • Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice.

    abstract：:Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are natu...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.105252

    authors： Lim DW,Park J,Jung J,Kim SH,Um MY,Yoon M,Kim YT,Han D,Lee C,Lee J

    更新日期：2020-11-01 00:00:00

  • The effect of morbid obesity on morphine glucuronidation.

    abstract：:The purpose of the present work was to study the change in morphine metabolic ratio in obese subjects before and after Roux-en-Y Gastric Bypass (RYGB) and to identify clinical and/or biological factors associated with this change. The pharmacokinetics (PK) of oral morphine (30mg), morphine-3-glucuronide (M3G) and morp...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2016.08.031

    authors： Lloret-Linares C,Luo H,Rouquette A,Labat L,Poitou C,Tordjman J,Bouillot JL,Mouly S,Scherrmann JM,Bergmann JF,Declèves X

    更新日期：2017-04-01 00:00:00

  • Sulforaphane protects ischemic injury of hearts through antioxidant pathway and mitochondrial K(ATP) channels.

    abstract：:Reactive oxygen species are important mediators that exert a toxic effect during ischemia-reperfusion (I/R) injury of various organs. Sulforaphane is known to be an indirect antioxidant that acts by inducing Nrf2-dependent phase 2 enzymes. In this study, we investigated whether sulforaphane protects heart against I/R ...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2009.11.009

    authors： Piao CS,Gao S,Lee GH,Kim DS,Park BH,Chae SW,Chae HJ,Kim SH

    更新日期：2010-04-01 00:00:00

  • Effects of nifedipine and Bay K 8644 on the R-PIA and caffeine-induced changes in the locomotor activity of rats.

    abstract：:Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.1996.0021

    authors： Eroglu L,Tuna R,Caglayan B

    更新日期：1996-02-01 00:00:00

  • Bmi1 drives the formation and development of intrahepatic cholangiocarcinoma independent of Ink4A/Arf repression.

    abstract：:Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.105365

    authors： Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

    更新日期：2020-12-08 00:00:00

  • MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.

    abstract：:As one classic anticancer drug, clinical application of Doxorubicin (Dox) is limited due to its side effects. In our previous work, we have investigated the drug targets to treat Dox-induced cardiotoxicity, hepatotoxicity and nephrotoxicity. In this paper, the mechanisms and new drug-target associated with Dox-induced...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2019.104276

    authors： Zhao X,Jin Y,Li L,Xu L,Tang Z,Qi Y,Yin L,Peng J

    更新日期：2019-08-01 00:00:00

  • Is there a place for tricyclic antidepressants and subsequent augmentation strategies in obtaining remission for patients with treatment resistant depression?

    abstract：:Major depressive disorder is a worrying mental health problem and obtaining remission from treatment resistant depression (TRD) remains an important clinical issue. Twenty patients (14 women, 6 men) considered as treatment resistant after the fourth step of a seven-step treatment algorithm to obtain remission in major...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2008.11.005

    authors： Gervasoni N,Aubry JM,Gex-Fabry M,Bertschy G,Bondolfi G

    更新日期：2009-03-01 00:00:00

  • Cardiotoxic interaction of metabolites from a prodrug segment cilexetil (cyclohexyloxy-carbonyloxy-ethyl) with digoxin in the canine failing heart.

    abstract：:Potential risks of cyclohexanol (CH) and cyclohexanediol (CHD) isomers, which are the metabolites derived from cilexetil ester side-chain of several prodrugs such as antibiotics (e.g. cefotiam hexetil) and an antihypertensive agent (candesartan cilexetil), were examined in beagles that were made congestive heart failu...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/s1043661802001743

    authors： Okunishi H,Shimoura K,Wang DQ,Kakizoe E

    更新日期：2002-10-01 00:00:00

  • Influence of a 3-day regimen of azithromycin on the disposition kinetics of cyclosporine A in stable renal transplant patients.

    abstract：:Some macrolide antibiotics have been shown to produce significant drug-drug interactions through the inhibition of cytochrome P450 (CYP) enzymes. In renal transplant patients these interactions pose potentially serious problems for the safe administration of cyclosporine A (CSA), a substrate of CYP3A4. The effects of ...

    journal_title：Pharmacological research

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1043-6618(03)00018-5

    authors： Bachmann K,Jauregui L,Chandra R,Thakker K

    更新日期：2003-06-01 00:00:00

  • Novel celecoxib analogues inhibit glial production of prostaglandin E2, nitric oxide, and oxygen radicals reverting the neuroinflammatory responses induced by misfolded prion protein fragment 90-231 or lipopolysaccharide.

    abstract：:We tested the efficacy of novel cyclooxygenase 2 (COX-2) inhibitors in counteracting glia-driven neuroinflammation induced by the amyloidogenic prion protein fragment PrP90-231 or lipopolysaccharide (LPS). In search for molecules with higher efficacy than celecoxib, we focused our study on its 2,3-diaryl-1,3-thiazolid...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2016.09.010

    authors： Villa V,Thellung S,Bajetto A,Gatta E,Robello M,Novelli F,Tasso B,Tonelli M,Florio T

    更新日期：2016-11-01 00:00:00

  • ATB-346, a novel hydrogen sulfide-releasing anti-inflammatory drug, induces apoptosis of human melanoma cells and inhibits melanoma development in vivo.

    abstract：:Inflammation plays a key role in tumor promotion and development. Indeed, cyclooxygenase-2 (COX-2) expression is strongly associated with different types of cancer. An emerging class of compounds with significant anti-inflammatory properties is the hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (H2S-...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2016.10.019

    authors： De Cicco P,Panza E,Ercolano G,Armogida C,Sessa G,Pirozzi G,Cirino G,Wallace JL,Ianaro A

    更新日期：2016-12-01 00:00:00

  • Lupeol and its derivatives as anticancer and anti-inflammatory agents: Molecular mechanisms and therapeutic efficacy.

    abstract：:Lupeol is a natural triterpenoid that widely exists in edible fruits and vegetables, and medicinal plants. In the last decade, a plethora of studies on the pharmacological activities of lupeol have been conducted and have demonstrated that lupeol possesses an extensive range of pharmacological activities such as antic...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2020.105373

    authors： Liu K,Zhang X,Xie L,Deng M,Chen H,Song J,Long J,Li X,Luo J

    更新日期：2020-12-11 00:00:00

  • The abundance of the long intergenic non-coding RNA 01087 differentiates between luminal and triple-negative breast cancers and predicts patient outcome.

    abstract：:The molecular complexity of human breast cancer (BC) renders the clinical management of the disease challenging. Long non-coding RNAs (lncRNAs) are promising biomarkers for BC patient stratification, early detection, and disease monitoring. Here, we identified the involvement of the long intergenic non-coding RNA 0108...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.105249

    authors： De Palma FDE,Del Monaco V,Pol JG,Kremer M,D'Argenio V,Stoll G,Montanaro D,Uszczyńska-Ratajczak B,Klein CC,Vlasova A,Botti G,D'Aiuto M,Baldi A,Guigó R,Kroemer G,Maiuri MC,Salvatore F

    更新日期：2020-11-01 00:00:00

  • Pharmacokinetic and chemoprevention studies on tea in humans.

    abstract：:Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolit...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2011.05.007

    authors： Chow HH,Hakim IA

    更新日期：2011-08-01 00:00:00

  • Allergic contact dermatitis: From pathophysiology to development of new preventive strategies.

    abstract：:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a s...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.105282

    authors： Brites GS,Ferreira I,Sebastião AI,Silva A,Carrascal M,Neves BM,Cruz MT

    更新日期：2020-12-01 00:00:00

  • Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo.

    abstract：:Our preliminary data suggested that 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene [Viale M, Ottone M, Chiavarina B, Mariggiò MA, Prevosto C, Dell'Erba C, et al. Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadi...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2005.03.011

    authors： Dell'Erba C,Chiavarina B,Fenoglio C,Petrillo G,Cordazzo C,Boncompagni E,Spinelli D,Ognio E,Aiello C,Mariggiò MA,Viale M

    更新日期：2005-09-01 00:00:00

  • Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin derivatives.

    abstract：:Chrysin, a natural flavone compound found in plants, has anti-inflammatory activity that has been previously explained in part by the suppression of promoter activities of pro-inflammatory enzymes, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS). Here we present evidence that several chrysin deriva...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/s1043-6618(03)00248-2

    authors： Cho H,Yun CW,Park WK,Kong JY,Kim KS,Park Y,Lee S,Kim BK

    更新日期：2004-01-01 00:00:00

  • Apigenin inhibits STAT3/CD36 signaling axis and reduces visceral obesity.

    abstract：:Visceral obesity is the excess deposition of visceral fat within the abdominal cavity that surrounds vital organs. Visceral obesity is directly associated with metabolic syndrome, breast cancer and endometrial cancer. In visceral obese subjects, signal transducer and activator of the transcription 3 (STAT3) in adipocy...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2019.104586

    authors： Su T,Huang C,Yang C,Jiang T,Su J,Chen M,Fatima S,Gong R,Hu X,Bian Z,Liu Z,Kwan HY

    更新日期：2020-02-01 00:00:00

  • Free radicals and antioxidant status following pylorus ligation induced gastric mucosal injury in rats.

    abstract：:The present investigation was undertaken to suggest the involvement of free radicals in the pathogenesis of pyloric ligation induced ulcers in rats. Lipid peroxidation product (MDA), antioxidant contents and secretory activity have been studied in the rat stomach at different time intervals after pylorus ligation indu...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.1998.0343

    authors： Rastogi L,Patnaik GK,Dikshit M

    更新日期：1998-08-01 00:00:00

  • Etrolizumab versus infliximab in the treatment of induction phase of ulcerative colitis: A systematic review and indirect comparison.

    abstract：OBJECTIVES:There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS...

    journal_title：Pharmacological research

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.phrs.2018.11.003

    authors： Motaghi E,Ghasemi-Pirbaluti M,Zabihi M

    更新日期：2019-01-01 00:00:00

  • Improved drug targeting of cancer cells by utilizing actively targetable folic acid-conjugated albumin nanospheres.

    abstract：:Folic acid-conjugated albumin nanospheres (FA-AN) have been developed to provide an actively targetable drug delivery system for improved drug targeting of cancer cells with reduced side effects. The nanospheres were prepared by conjugating folic acid onto the surface of albumin nanospheres using 1-ethyl-3-(3-dimethyl...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2010.10.012

    authors： Shen Z,Li Y,Kohama K,Oneill B,Bi J

    更新日期：2011-01-01 00:00:00