Abstract：
:Aminoglycoside antibiotics are employed clinically because of their potent bactericidal activities, less bacterial resistance, post-antibiotic effects and low cost. However, drugs belong to this class are well-known to cause nephrotoxicity, which limits their frequent clinical exploitation. Gentamicin, a commonly used aminoglycoside, is associated with an induction of tubular necrosis, epithelial oedema of proximal tubules, cellular desquamation, tubular fibrosis, glomerular congestion, perivascular edema and inflammation, which ultimately show the way to renal dysfunction. It is a matter of debate whether we have promising agents to prevent the incidence of gentamicin-induced nephrotoxicity. The present review critically discussed the pathogenesis of gentamicin-induced nephrotoxicity. In addition, based on the experimental and clinical studies, the possible therapeutic approach to prevent gentamicin-induced nephrotoxicity has been discussed.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Balakumar P,Rohilla A,Thangathirupathi Adoi
10.1016/j.phrs.2010.04.004subject
Has Abstractpub_date
2010-09-01 00:00:00pages
179-86issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(10)00103-9journal_volume
62pub_type
杂志文章,评审abstract：:The possible involvement of adenosine 5'-triphosphate (ATP) receptors in the function of the hippocampus is reviewed. The involvement of these receptors in the hippocampus is suggested by data that ATP is released from hippocampal slices [1] and that it also induces fast synaptic currents in cultured hippocampal neuro...
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