Abstract：
:Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in vivo in dissolving coronary thrombi. Clinical studies supported this concept. However, the beneficial effects of these drugs were, to some extent, offset by their inherent adverse reactions. Therefore new thrombolytic agents were developed, and for three of them (APSAC, tPA and proUK) there are enough clinical studies to allow for a comparison with 'old' agents. The data show that none of the new agents is safer or better than old agents with respect to easy handling, incidence of reperfusion of occluded coronary arteries, frequency of reocclusions, thrombus specificity, and bleeding complications. Thus, several directions are currently pursued to develop newer thrombolytic drugs with risk/benefit ratios better than those of 'old' agents. In this respect, it has been shown recently that the combination of aspirin with streptokinase is significantly better than streptokinase alone as far as mortality and incidence of rethrombosis is concerned. These data suggest that thrombolytic approaches safer and better than those currently available are possible and indicate that some of such new strategies are already available to enter the 'thrombolytic era' of acute MI.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei Adoi
10.1016/1043-6618(89)90233-8subject
Has Abstractpub_date
1989-03-01 00:00:00pages
153-61issue
2eissn
1043-6618issn
1096-1186pii
1043-6618(89)90233-8journal_volume
21pub_type
杂志文章,评审abstract：:The hepatoprotective effects of acetylbergenin were examined against D -galactosamine (GalN)-induced liver damage in rats, compared with that of bergenin reported previously. Acetylbergenin was synthesized from acetylation of bergenin, isolated from Mallotus japonicus, to increase lipophilic and physiological activiti...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.2000.0730
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2020.104721
更新日期：2020-05-01 00:00:00
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2009.11.014
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2018-07-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2018-09-01 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Thymidylate synthase (TS) expression levels appear to be related to response to 5-fluorouracil-(5-FU)-based chemotherapy in colorectal cancer (CRC) patients. Three polymorphisms have been proposed as modulators of TS expression: a tandemly repeated sequence (2R/3R) in the 5' UTR, a SNP (G>C) w...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2009.11.009
更新日期：2010-04-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2020-10-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2016.08.001
更新日期：2016-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/s1043-6618(03)00045-8
更新日期：2003-06-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2020.105223
更新日期：2020-11-01 00:00:00
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更新日期：2021-01-13 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2007-03-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2016-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2020-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
abstract：:Combination antiretroviral therapy reduces morbidity and mortality in HIV infected patients. However, the cure of HIV infection is hindered by the persistence of the latent HIV reservoir. Latency reversing agents (LRAs) are developed to target the HIV latently infected cells for HIV reactivation. In addition to revers...
journal_title：Pharmacological research
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更新日期：2019-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,meta分析
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更新日期：2020-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2019-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,meta分析,评审
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更新日期：2016-08-01 00:00:00
abstract：:The DNA microarrays have proven to be a state of the art technique for high throughput comprehensive analysis of thousand of genes in parallel. The application of a DNA microarray to compare normal and pathological cells, tissues or organs may allow, along with classical positional cloning techniques, to speed up the ...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2003.06.001
更新日期：2004-04-01 00:00:00
