The effects of a nutraceutical combination on plasma lipids and glucose: A systematic review and meta-analysis of randomized controlled trials.

abstract：:Skeletal muscle fitness is vital for human health and disease and is determined by the capacity for burning fuel, mitochondrial ATP production, and contraction. High quality mitochondria in skeletal muscle are essential for maintaining energy homeostasis in response to a myriad of physiologic or pathophysiological str...

journal_title：Pharmacological research

authors： Xu Z,Fu T,Guo Q,Sun W,Gan Z

更新日期：2019-03-01 00:00:00

abstract：:The objective of the study was to investigate possible changes in vancomycin serum levels induced by cardio-pulmonary bypass (CPB). Ten cardiac patients (seven males, three females, aged between 56 and 81), who underwent cardiac surgery requiring CPB, took part in the study. Vancomycin (15 mg kg-1) was intravenously i...

journal_title：Pharmacological research

authors： Miglioli PA,Merlo F,Grabocka E,Padrini R

更新日期：1998-10-01 00:00:00

abstract：:Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1997-12-01 00:00:00

abstract：:Our preliminary data suggested that 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene [Viale M, Ottone M, Chiavarina B, Mariggiò MA, Prevosto C, Dell'Erba C, et al. Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadi...

journal_title：Pharmacological research

authors： Dell'Erba C,Chiavarina B,Fenoglio C,Petrillo G,Cordazzo C,Boncompagni E,Spinelli D,Ognio E,Aiello C,Mariggiò MA,Viale M

更新日期：2005-09-01 00:00:00

abstract：:Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however...

journal_title：Pharmacological research

authors： Kaushik S,Cuervo AM

更新日期：2012-12-01 00:00:00

abstract：:Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

journal_title：Pharmacological research

authors： Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

更新日期：1999-08-01 00:00:00

abstract：:We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition me...

journal_title：Pharmacological research

authors： Winnicka MM,Braszko JJ,Wiśniewski K

更新日期：1997-11-01 00:00:00

abstract：:The intestinal barrier function depends on an adequate response to pathogens by the epithelium. Toll-like receptor 3 (TLR-3) recognizes double-stranded RNA, a virus-associated molecular pattern. Activation of TLR-3 with Poly(I:C), a synthetic agonist, modulates tissue repair and permeability in other epithelia; howeve...

journal_title：Pharmacological research

authors： Moyano-Porcile V,Olavarría-Ramírez L,González-Arancibia C,Bravo JA,Julio-Pieper M

更新日期：2015-11-01 00:00:00

abstract：:The most frequent cause of mortality and morbidity in industrialized countries is coronary artery disease (CAD), which in Europe alone is responsible for around two million deaths per year. In 2001 it accounted for about 260,000 hospital discharges in Italy. The costs of CAD treatment in Italy--which were borne by the...

journal_title：Pharmacological research

authors： De Portu S,Menditto E,Scalone L,Bustacchini S,Cricelli C,Mantovani LG

更新日期：2006-08-01 00:00:00

abstract：:Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present study investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial infarction given specifically at reperfusion and the signalling pathway involved. Thiobutabarb...

journal_title：Pharmacological research

authors： Karwi QG,Whiteman M,Wood ME,Torregrossa R,Baxter GF

更新日期：2016-09-01 00:00:00

abstract：:Cannabinoids have emerged as promising neuroprotective agents due to their capability to activate specific targets, which are involved in the control of neuronal homeostasis and survival. Specifically, those ligands that selectively target and activate the CB2 receptor may be useful for their anti-inflammatory and neu...

journal_title：Pharmacological research

authors： Gómez-Cañas M,Morales P,García-Toscano L,Navarrete C,Muñoz E,Jagerovic N,Fernández-Ruiz J,García-Arencibia M,Pazos MR

更新日期：2016-08-01 00:00:00

abstract：:The antinociceptive and motor effects of the hydrophilic alpha 2-adrenoceptor agonist ST-91 were studied after intrathecal administration to male Wistar rats in different heat-pain tests and different test settings. Intrathecal administration of ST-91 caused a dose-dependent increase in hind paw licking latency in the...

journal_title：Pharmacological research

authors： Horváth G,Dobos I,Liszli P,Klimscha W,Szikszay M,Benedek G

更新日期：1997-06-01 00:00:00

abstract：:Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent...

journal_title：Pharmacological research

authors： Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

更新日期：2017-08-01 00:00:00

abstract：:The effect of age and sex on the predictive value of colorectal cancer (CRC) patients treated with immune checkpoint inhibitors (ICIs) has been controversial, and the effect of specific gene mutations on the predictive value of CRC patients treated with ICIs remains to be explored. Our study analyzed the influence of ...

journal_title：Pharmacological research

authors： Lin A,Zhang H,Hu X,Chen X,Wu G,Luo P,Zhang J

更新日期：2020-09-01 00:00:00

abstract：:The aqueous extract from aerial parts of Artemisia copa Phil. (Compositae), was evaluated for antinociceptive activity using writhing, formalin, and hot-plate tests in mice. A dose-related antinociceptive response was obtained in the writhing test at doses of 500 and 1000 mg/kg p.o. (percentage of inhibition 23.3 and ...

journal_title：Pharmacological research

authors： Miño J,Moscatelli V,Hnatyszyn O,Gorzalczany S,Acevedo C,Ferraro G

更新日期：2004-07-01 00:00:00

abstract：:Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...

journal_title：Pharmacological research

authors： Varotto-Boccazzi I,Epis S,Arnoldi I,Corbett Y,Gabrieli P,Paroni M,Nodari R,Basilico N,Sacchi L,Gramiccia M,Gradoni L,Tranquillo V,Bandi C

更新日期：2020-11-01 00:00:00

abstract：:In addiction, an individual's ability to inhibit drug seeking and drug taking is thought to reflect a pathological strengthening of drug-seeking behaviors or impairments in the capacity to control maladaptive behavior. These processes are not mutually exclusive and reflect drug-induced modifications within prefrontal ...

journal_title：Pharmacological research

authors： Hearing M

更新日期：2019-01-01 00:00:00

abstract：:Implantable cardioverter-defibrillators (ICDs) have revolutionized the primary and secondary prevention of patients with ventricular arrhythmias. However, the adverse effects of appropriate or inappropriate shocks may require the adjunctive use of anti-arrhythmic drugs (AADs). Beta blockers are the cornerstone of phar...

journal_title：Pharmacological research

authors： AlTurki A,Proietti R,Russo V,Dhanjal T,Banerjee P,Essebag V

更新日期：2019-05-01 00:00:00

abstract：:The mitochondrial citrate carrier (CIC) is a nuclear-encoded protein located in the inner mitochondrial membrane. By mediating efflux of citrate from the mitochondria to the cytosol, CIC links mitochondrial central carbon metabolism and cytosolic lipogenesis together. Abnormal activity or expression of CIC was found i...

journal_title：Pharmacological research

authors： Peng R,Zhang M,Wang H,Lin J,Wang H,Wang F,Liu L,Zhao Q,Liu J

更新日期：2020-11-01 00:00:00

abstract：:Baroreflex plays a crucial role in regulation of arterial blood pressure (BP). Recently, Piezo1 and Piezo2, the mechanically-activated (MA) ion channels, have been identified as baroreceptors. However, the underlying molecular mechanism for regulating these baroreceptors in hypertension remains unknown. In this study,...

journal_title：Pharmacological research

authors： Huo L,Gao Y,Zhang D,Wang S,Han Y,Men H,Yang Z,Qin X,Wang R,Kong D,Bai H,Zhang H,Zhang W,Jia Z

更新日期：2020-12-19 00:00:00

abstract：:Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-beta-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to influence halothane...

journal_title：Pharmacological research

authors： Harrison GG,Dyer RA,Llewellyn RL,James MF

更新日期：1999-02-01 00:00:00

abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

journal_title：Pharmacological research

authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

更新日期：2007-12-01 00:00:00

abstract：:Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries. In the majority of cases, HEV causes a self-limiting hepatitis. GT3 and GT4 can be responsib...

journal_title：Pharmacological research

authors： De Winter BCM,Hesselink DA,Kamar N

更新日期：2018-04-01 00:00:00

abstract：:The role of the angiotensin AT1 receptors in certain behavioural effects of angiotensin II (Ang II), using their selective antagonist losartan (DuP 753), was assessed. Ang II, given intracerebroventricularly (ICV) at the dose of 1 nmole, significantly improved object recognition, learning of conditioned avoidance resp...

journal_title：Pharmacological research

authors： Kułakowska A,Karwowska W,Wiśniewski K,Braszko JJ

更新日期：1996-09-01 00:00:00

abstract：:The cytoprotective activity of alpha-lipoic acid against free radical toxicity, manifested during experimental hyperoxaluria, has been investigated. Glycollate was used as the inducer of oxalate hyperoxaluria in rats. The increase in lipid peroxidation and superoxide dismutase (SOD) activity, associated with a decreas...

journal_title：Pharmacological research

authors： Sumathi R,Jayanthi S,Kalpanadevi V,Varalakshmi P

更新日期：1993-05-01 00:00:00

abstract：:In China, child and adolescent pediatricians often face challenges in treating children with the appropriate medications. Within the last 8 years, the Chinese government has already initiated a series of policies to promote development of age-appropriate medicines for children. In this study,we introduced the current ...

journal_title：Pharmacological research

authors： Wu W,Tang Z,Chen J,Gao Y

更新日期：2019-10-01 00:00:00

abstract：:Tissue subjected to a period of ischemia undergoes functional and morphological damage that increases during the reperfusion phase. In this study, the protective effect of aprotinin, which is a protease inhibitor, was assessed in a rabbit unilateral renal ischemia-reperfusion (I/R) model. New Zealand rabbits, weighing...

journal_title：Pharmacological research

authors： Ozer Z,Sucu N,Düşmez D,Tamer L,Altunkan AA,DIkmengIl M,Oral U

更新日期：2001-12-01 00:00:00

abstract：:The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is n...

journal_title：Pharmacological research

authors： Fleming I

更新日期：2004-06-01 00:00:00

abstract：:PI3K was originally discovered as a lipid kinase involved in the phosphorylation of the inositol ring in position -3, leading to the synthesis of phosphatidyl-inositol-3-4 bisphosphate. The enzyme purified from rat liver is an heterodimer of two subunits of 85 and 110 KD respectively: it phosphorylates the D3 hydroxyl...

journal_title：Pharmacological research

authors： Chiarugi V

更新日期：1997-04-01 00:00:00

abstract：:The effect of flumazenil (FLU) on plasma protein binding of diazepam (DZ), nordiazepam (ND) and oxazepam (OX) was determined in plasma from drug-naive dogs to which graded concentrations of tested drugs alone and in combination were added. The results revealed that as the concentration of FLU added to plasma alone was...

journal_title：Pharmacological research

authors： Wala EP,Sloan JW

更新日期：1995-11-01 00:00:00