Prefrontal-accumbens opioid plasticity: Implications for relapse and dependence.

abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...

journal_title：Pharmacological research

authors： Faillie JL

更新日期：2017-04-01 00:00:00

abstract：:Moderate wine consumption has been shown to reduce cardiovascular (CV) risk, due to alcohol and polyphenolic compounds, such as resveratrol. We investigated the associations between total urinary resveratrol metabolites (TRMs) as biomarkers of wine and resveratrol consumption and CV risk factors in a large cross-secti...

journal_title：Pharmacological research

authors： Zamora-Ros R,Urpi-Sarda M,Lamuela-Raventós RM,Martínez-González MÁ,Salas-Salvadó J,Arós F,Fitó M,Lapetra J,Estruch R,Andres-Lacueva C,PREDIMED Study Investigators.

更新日期：2012-06-01 00:00:00

abstract：:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic...

journal_title：Pharmacological research

authors： Caselli C,D'Amico A,Cabiati M,Prescimone T,Del Ry S,Giannessi D

更新日期：2014-04-01 00:00:00

abstract：:Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

journal_title：Pharmacological research

authors： Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

更新日期：1999-08-01 00:00:00

abstract：:Purine release and prostaglandin (PG) outflow were simultaneously evaluated from untreated glial primary cultures of rat striatum, at rest and under field electrical stimulation. Purine release was also assayed from sister cultured cells in which a suitable pharmacological treatment with 1 x 10(-6) M dexamethasone or ...

journal_title：Pharmacological research

authors： Caciagli F,Ciccarelli R,Di Iorio P,Tacconelli L,Ballerini P

更新日期：1989-05-01 00:00:00

abstract：:Alzheimer's disease is the fourth largest cause of death for people over 65 years of age. Dementia of Alzheimer's type is the commonest form of dementia, the other two forms being vascular dementia and mixed dementia. At present, the therapy of Alzheimer's disease is aimed at improving both, cognitive and behavioural ...

journal_title：Pharmacological research

authors： Sonkusare SK,Kaul CL,Ramarao P

更新日期：2005-01-01 00:00:00

abstract：:The antinociceptive effect of the D(2) antagonist prochlorperazine was examined in the mouse hot-plate and abdominal constriction tests. Prochlorperazine (1-2 mg kg(-1) s.c./i.p.) produced an increase of the pain threshold in the mouse hot-plate test. The antinociception produced by prochlorperazine was prevented by t...

journal_title：Pharmacological research

authors： Ghelardini C,Galeotti N,Uslenghi C,Grazioli I,Bartolini A

更新日期：2004-09-01 00:00:00

abstract：:The pharmacokinetics of doxycycline hydrochloride (DoxHcl) at a dose of 5 mg kg-1 BW was studied after an intravenous (i.v.) bolus and intramuscular (i.m.) injections in non lactating goats. A microbiological assay employing Bacillus subtilis as the test organism was used to measure its concentrations in serum and uri...

journal_title：Pharmacological research

authors： Abd El-Aty AM,Goudah A,Zhou HH

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND AND PURPOSE:Chronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar damage and generally irreversible airflow limitation. Nuclear factor-κB (NF-κB) plays a critical role in COPD pathogenesis. Receptor-interacting protein 2 (Rip2), a 60 kDa adaptor protein, is a positive regulato...

journal_title：Pharmacological research

authors： Dong J,Liao W,Tan LH,Yong A,Peh WY,Wong WSF

更新日期：2019-01-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used as analgesics. Although the results of clinical studies indicate considerable disparity in the analgesic efficacy of NSAIDs, the pre-clinical models generally used for the study of nociception do not allow a clear distinction to be made between the ana...

journal_title：Pharmacological research

authors： Bianchi M,Panerai AE

更新日期：2002-02-01 00:00:00

abstract：:Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6....

journal_title：Pharmacological research

authors： Chae HJ,Kim SC,Chae SW,An NH,Kim HH,Lee ZH,Kim HR

更新日期：2001-03-01 00:00:00

abstract：:Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...

journal_title：Pharmacological research

authors： Xu L,Li Y,Dai Y,Peng J

更新日期：2018-04-01 00:00:00

abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

journal_title：Pharmacological research

authors： Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

更新日期：2000-01-01 00:00:00

abstract：:Flibanserin has been reported to be an agonist at 5-HT1A-receptors and an antagonist at 5-HT2A receptors, with higher affinity for 5-HT1A receptors. Despite the fact that less receptor occupation is required by full agonists than by antagonists to exert their effects, flibanserin was shown to exert 5-HT2A antagonism a...

journal_title：Pharmacological research

authors： Scandroglio A,Monferini E,Borsini F

更新日期：2001-02-01 00:00:00

abstract：:Antioxidants have a great potential as adjuvant therapeutics in patients with Duchenne muscular dystrophy, although systematic comparisons at pre-clinical level are limited. The present study is a head-to-head assessment, in the exercised mdx mouse model of DMD, of natural compounds, resveratrol and apocynin, and of t...

journal_title：Pharmacological research

authors： Capogrosso RF,Cozzoli A,Mantuano P,Camerino GM,Massari AM,Sblendorio VT,De Bellis M,Tamma R,Giustino A,Nico B,Montagnani M,De Luca A

更新日期：2016-04-01 00:00:00

abstract：:Heart rate slowing has been accepted for decades as a primary therapeutic approach to prevention (and even to treatment) of angina pectoris. Pure heart rate slowing has not been achieved with previously available rate-slowing pharmacological agents (beta adrenergic blockers, certain calcium channel blockers), all of w...

journal_title：Pharmacological research

authors： Borer JS

更新日期：2006-05-01 00:00:00

abstract：:The mechanism for the pathological increase in cell death in various disease states e.g. HIV immunodefficiency or even ageing or Alzheimer's disease, occurs by complex and as yet undefined mechanism(s) related to immunological, virological or biochemical disturbances (i.e. energy depletion, oxidative stress, increased...

journal_title：Pharmacological research

authors： Virmani MA,Biselli R,Spadoni A,Rossi S,Corsico N,Calvani M,Fattorossi A,De Simone C,Arrigoni-Martelli E

更新日期：1995-12-01 00:00:00

abstract：:We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

journal_title：Pharmacological research

authors： Campos BG,Ferreira RR,Gomes JC

更新日期：2000-03-01 00:00:00

abstract：:Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by motor neurons degeneration and muscular atrophy. There is no effective SMA treatment. Loganin is a botanical candidate with anti-inflammatory, anti-oxidant, glucose-lowering and anti-diabetic nephropathy activities. The ...

journal_title：Pharmacological research

authors： Tseng YT,Chen CS,Jong YJ,Chang FR,Lo YC

更新日期：2016-09-01 00:00:00

abstract：:The review emphasizes the role of NGF, the most representative member of the neurotrophins family, in cardiac physiopathology with a particular focus on healing and sprouting processes occurring after tissue damage. Cardiac and circulating NGF levels dramatically increase following myocardial injury (MI). A very early...

journal_title：Pharmacological research

authors： Govoni S,Pascale A,Amadio M,Calvillo L,D'Elia E,Cereda C,Fantucci P,Ceroni M,Vanoli E

更新日期：2011-04-01 00:00:00

abstract：:Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack...

journal_title：Pharmacological research

authors： Wu T,Yu GY,Xiao J,Yan C,Kurihara H,Li YF,So KF,He RR

更新日期：2018-07-01 00:00:00

abstract：:Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate pr...

journal_title：Pharmacological research

authors： Oner-Iyidoğan Y,Oner P,Koçak H,Lama A,Gürdöl F,Bekpinar S,Unur N,Ozbek-Kir Z

更新日期：2005-10-01 00:00:00

abstract：:The principle of mechanopharmacology of airway smooth muscle (ASM) is based on the premise that physical agitation, such as pressure oscillation applied to an airway, is able to induce bronchodilation by reducing contractility and softening the cytoskeleton of ASM. Although the underlying mechanism is not entirely cle...

journal_title：Pharmacological research

authors： Wang L,Chitano P,Seow CY

更新日期：2020-09-01 00:00:00

abstract：:An interaction of drug with food, herbs, and dietary supplements is usually the consequence of a physical, chemical or physiologic relationship between a drug and a product consumed as food, nutritional supplement or over-the-counter medicinal plant. The current educational review aims at reminding to the prescribing ...

journal_title：Pharmacological research

authors： Mouly S,Lloret-Linares C,Sellier PO,Sene D,Bergmann JF

更新日期：2017-04-01 00:00:00

abstract：:Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent...

journal_title：Pharmacological research

authors： Zhu R,Liu H,Liu C,Wang L,Ma R,Chen B,Li L,Niu J,Fu M,Zhang D,Gao S

更新日期：2017-08-01 00:00:00

abstract：:This paper discusses the discovery of ligands for orphan receptors and the identification of the natural endogenous ligands for those receptors in physiology. The central thesis is that orphan seven transmembrane receptors (7TMRs) are allosteric conduits of chemical information exchange from extracellular ligands to i...

journal_title：Pharmacological research

authors： Kenakin TP

更新日期：2016-12-01 00:00:00

abstract：AIM:To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation. METHODS:We enrolled 532 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of...

journal_title：Pharmacological research

authors： Derosa G,Maffioli P,Scelsi L,Bestetti A,Vanasia M,Cicero AFG,Spinardi L,Bentivenga C,Esposti DD,Caprio M,Borghi C,Pitt B,Cosentino E

更新日期：2019-03-01 00:00:00

abstract：:Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper-stimulation of G protein couple receptors (GPCRs) and downstream signaling components. Although GPCR blockade is a key component of current anti-hypertensive strategies, whether hypertension is better managed by directly targeting...

journal_title：Pharmacological research

authors： Meleka MM,Edwards AJ,Xia J,Dahlen SA,Mohanty I,Medcalf M,Aggarwal S,Moeller KD,Mortensen OV,Osei-Owusu P

更新日期：2019-03-01 00:00:00

abstract：:Proton pump inhibitors (PPIs) are used widely for the treatment of acid-related disorders. Despite their excellent efficacy and tolerance, the pharmacodynamics and pharmacokinetics of PPIs are affected by each patient's CYP2C19 and gastric H+,K+-ATPase genotype. The aim of this review was to analyze the effect of gene...

journal_title：Pharmacological research

authors： Zhang HJ,Zhang XH,Liu J,Sun LN,Shen YW,Zhou C,Zhang HW,Xie LJ,Chen J,Liu Y,Wang YQ

更新日期：2020-02-01 00:00:00

abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

journal_title：Pharmacological research

authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

更新日期：2007-12-01 00:00:00