The potentiation of the histamine release induced by adenosine in mast cells from guinea pig lung and heart: sharp dependence on the time of preincubation.

abstract：:The synergistic protective effect of nicorandil (KATP channel opener) and amlodipine (calcium channel blocker) on mitochondrial respiration and mitochondrial lipid contents were examined on isoproterenol-induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for 2 days showed s...

journal_title：Pharmacological research

authors： Sathish V,Ebenezar KK,Devaki T

更新日期：2003-12-01 00:00:00

abstract：:The effect of gentamicin on both glutamate synthesis and glutamate deamination was studied in kidney-cortex mitochondria and tubules isolated from both control and gentamicin-treated animals. In kidney-cortex mitochondria which were permeabilized in order to make a free access of substrates and antibiotic to the gluta...

journal_title：Pharmacological research

authors： Bryła J,Lietz T,Jarzyna R,Michalik M,Pietkiewicz J

更新日期：1992-12-01 00:00:00

abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...

journal_title：Pharmacological research

authors： Misirkic M,Janjetovic K,Vucicevic L,Tovilovic G,Ristic B,Vilimanovich U,Harhaji-Trajkovic L,Sumarac-Dumanovic M,Micic D,Bumbasirevic V,Trajkovic V

更新日期：2012-01-01 00:00:00

abstract：:Nanotechnology applications in medicine, termed as nanomedicine, have introduced a number of nanoparticles of variable chemistry and architecture for cancer imaging and treatment. Nanotechnology involves engineering multifunctional devices with dimensions at the nanoscale, similar dimensions as those of large biologic...

journal_title：Pharmacological research

authors： Wang M,Thanou M

更新日期：2010-08-01 00:00:00

abstract：AIM:Acute myocardial infarction and subsequent post-infarction heart failure are among the leading causes of mortality worldwide. The endocannabinoid system has emerged as an important modulator of cardiovascular disease, however the role of endocannabinoid metabolic enzymes in heart failure is still elusive. Herein, w...

journal_title：Pharmacological research

authors： van Esbroeck ACM,Varga ZV,Di X,van Rooden EJ,Tóth VE,Onódi Z,Kuśmierczyk M,Leszek P,Ferdinandy P,Hankemeier T,van der Stelt M,Pacher P

更新日期：2020-01-01 00:00:00

abstract：:Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

journal_title：Pharmacological research

authors： Csaba G,Kovács P,Pállinger E

更新日期：2003-11-01 00:00:00

abstract：:Src homology-2-containing protein tyrosine phosphatase 2 (SHP2) is a major phosphatase involved in several cellular processes. In recent years, SHP2 has been the focus of significant attention in human diseases, particular in cancer. Several studies have shown that SHP2 plays an important role in regulating immune cel...

journal_title：Pharmacological research

authors： Liu Q,Qu J,Zhao M,Xu Q,Sun Y

更新日期：2020-02-01 00:00:00

abstract：:Metastatic and primary bone cancers are usually accompanied by severe pain that is difficult to manage. In light of the adverse side effects of opioids, manipulation of the endocannabinoid system may provide an effective alternative for the treatment of cancer pain. The present study determined that a local, periphera...

journal_title：Pharmacological research

authors： Khasabova IA,Chandiramani A,Harding-Rose C,Simone DA,Seybold VS

更新日期：2011-07-01 00:00:00

abstract：:The modification in the composition of bile acids in hamster by the administration of high dose of ursodeoxycholic acid (UDCA) was investigated. Male Golden Syrian hamsters were divided into five groups: a control group, two groups that received 0.5 g of UDCA per 100 g of standard diet during 30 and 60 days and anothe...

journal_title：Pharmacological research

authors： Matejka M,Vescina C,Carducci CN,Alayón A,Dios A,Scarlatto E,Mamianetti A

更新日期：1990-05-01 00:00:00

abstract：:"Funny" (f) channels underlie the cardiac "pacemaker"I(f) current, originally described as an inward current activated on hyperpolarization to the diastolic range of voltages in sino-atrial node myocytes [Brown, HF, DiFrancesco, D, Noble, SJ. How does adrenaline accelerate the heart? Nature 1979;280:235-236]. The invo...

journal_title：Pharmacological research

authors： DiFrancesco D

更新日期：2006-05-01 00:00:00

abstract：:Boldo (Peumus boldus Mol.), a Chilean tree traditionally employed in folk medicine and recognized as a herbal remedy in a number of pharmacopoeias, mainly for the treatment of liver ailments, has recently been the subject of increasing attention. Boldine, in particular, the major and most characteristic alkaloidal con...

journal_title：Pharmacological research

authors： Speisky H,Cassels BK

更新日期：1994-01-01 00:00:00

abstract：:One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessin...

journal_title：Pharmacological research

authors： Reis F,Tavares P,Teixeira F

更新日期：2000-02-01 00:00:00

abstract：:Ginseng is one of the most popular herbal remedies. Studies were performed in anaesthetized rats to examine the effect of ginseng on bile secretion. Male Sprague-Dawley rats were anaesthetized with intraperitoneal (i.p.) urethane (1.25 g kg(-1)) and equipped with biliary cannulas inserted into the bile duct through th...

journal_title：Pharmacological research

authors： Salam OM,Nada SA,Arbid MS

更新日期：2002-04-01 00:00:00

abstract：:The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyruvic acid, succinic acid and glutamic acid. The meglitinide a...

journal_title：Pharmacological research

authors： Bakkali Nadi A,Zhang TM,Malaisse WJ

更新日期：1996-03-01 00:00:00

abstract：:The present study was designed to investigate the ameliorative potential of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, in tibial and sural nerve transection-induced neuropathic pain in rats. The pinprick, cold immersion, hot plate and hot immersion tests were performed to a...

journal_title：Pharmacological research

authors： Jain V,Jaggi AS,Singh N

更新日期：2009-06-01 00:00:00

abstract：:The sphingolipid field has made significant strides over the past 10 years: from identifying metabolites of the sphingomyelin pathway as second messengers to discerning the molecular biology and biophysics of these lipid-derived second messengers. Building upon this vast basic science literature, scientists from multi...

journal_title：Pharmacological research

authors： Kester M,Kolesnick R

更新日期：2003-05-01 00:00:00

abstract：:An interaction of drug with food, herbs, and dietary supplements is usually the consequence of a physical, chemical or physiologic relationship between a drug and a product consumed as food, nutritional supplement or over-the-counter medicinal plant. The current educational review aims at reminding to the prescribing ...

journal_title：Pharmacological research

authors： Mouly S,Lloret-Linares C,Sellier PO,Sene D,Bergmann JF

更新日期：2017-04-01 00:00:00

abstract：:The first studies of histamine and diabetes date back to the 1950s. Since that time the involvement of histamine in diabetes was related to its well known vasoactive properties and permeability leakage effects. In particular, the first evidence for a correlation between histamine and diabetes arose in 1989 when an inc...

journal_title：Pharmacological research

authors： Pini A,Obara I,Battell E,Chazot PL,Rosa AC

更新日期：2016-09-01 00:00:00

abstract：:In the present study, an attempt has been made to elucidate the role of alpha 2-adrenoceptors in reserpine-induced emesis in pigeons. Reserpine was found to induce dose-dependent emesis and a 500 micrograms kg-1 dose was found to be the 100% emetic dose. alpha 2-adrenoceptor agonists clonidine and alpha-methylnoradren...

journal_title：Pharmacological research

authors： Khandker SK,Mukerjee D,Gurtu S,Pant KK,Dhawan KN,Sinha JN

更新日期：1994-05-01 00:00:00

abstract：:We have shown previously that the antitumor drug, hydroxyurea (HU) is able to induce dose-dependent increases in plasma corticosterone levels in the rat. The drug was administered early in the morning, when the levels of circulating glucocorticoids are low in this species. Normally, in humans under physiological condi...

journal_title：Pharmacological research

authors： Navarra P,Aloe-Spiriti MA,Boccarini F,Montefusco E,Latagliata R,Preziosi P,Petti MC

更新日期：2000-10-01 00:00:00

abstract：:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses c...

journal_title：Pharmacological research

authors： Costa Queiroz RH,de Souza AM,Sampaio SV,Melchior E Jr

更新日期：2002-08-01 00:00:00

abstract：:The aim of this study was to investigate the effects of manganese chloride on gentamicin-induced nephrotoxicity in rats. Thirty-six adult Wistar Albino rats were divided into six equal groups. They were injected with gentamicin sulfate (100 mg kg(-1) per day i.p.) and manganese chloride (2 or 20 mg kg(-1) per day i.p....

journal_title：Pharmacological research

authors： Ateşşahin A,Karahan I,Yilmaz S,Ceribaşi AO,Princci I

更新日期：2003-12-01 00:00:00

abstract：:Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions. In this work, we ...

journal_title：Pharmacological research

authors： Gómez-Escribano AP,Bono-Yagüe J,García-Gimeno MA,Sequedo MD,Hervás D,Fornés-Ferrer V,Torres-Sánchez SC,Millán JM,Sanz P,Vázquez-Manrique RP

更新日期：2020-11-01 00:00:00

abstract：:Beta-endorphin/beta-lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain p...

journal_title：Pharmacological research

authors： Salar G,Alessio L,Govoni S,Battaini F,Iob I,Goss I,Trabucchi M

更新日期：1991-02-01 00:00:00

abstract：:Cicletanine [(+/-)-C] is a racemic furopyridine derivative used as an antihypertensive agent. Pharmacokinetic and metabolic studies have shown that cicletanine is rapidly and almost fully metabolized into sulfo- and glucuro-conjugated metabolites. However, the stereoselective metabolism of cicletanine is not well-know...

journal_title：Pharmacological research

authors： Menard C,Lamiable D,Vistelle R,Morin E,Ratanasavanh D

更新日期：2000-07-01 00:00:00

abstract：:Local microcirculatory dysfunction within the pancreatic gland might be an important factor in the conversion of oedematous to necrotizing pancreatitis. Therapeutic agents, improving the pancreatic blood flow, might be valuable in acute pancreatitis treatment. An influence of nitric oxide, heparin and procaine treatme...

journal_title：Pharmacological research

authors： Dobosz M,Hac S,Mionskowska L,Dobrowolski S,Wajda Z

更新日期：1997-08-01 00:00:00

abstract：:Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

journal_title：Pharmacological research

authors： Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

更新日期：1989-03-01 00:00:00

abstract：:Progressive neuronal death is the key pathogenic event leading to clinical symptoms in neurodegenerative disorders (NDDs). Neuroprotective treatments are virtually unavailable, partly because of the marked internal heterogeneity of the mechanisms underlying pathology. Targeted neuroprotection would require deep mechan...

journal_title：Pharmacological research

authors： Masi A,Narducci R,Mannaioni G

更新日期：2019-09-01 00:00:00

abstract：:The effect of fluvoxamine (FLV) a selective serotonin reuptake inhibitor agent was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. FLV (8-64 microM) caused a dose-dependent decrease in the rate of contractions (7-52%) and in the contractile force (11-57%). Ouabain alone (2 mic...

journal_title：Pharmacological research

authors： Pousti A,Deemyad T,Brumand K,Bakhtiarian A

更新日期：2005-08-01 00:00:00

abstract：:Biochemical evaluations of the effects of the sulfhydryl-containing angiotensin-converting enzyme inhibitor (captopril) on the nephrotoxicity induced by doxorubicin in normal rats were carried out. A single dose of doxorubicin (15 mg kg-1) which caused nephrotoxicity was manifested biochemically by the elevation of se...

journal_title：Pharmacological research

authors： Mansour MA,El-Kashef HA,Al-Shabanah OA

更新日期：1999-03-01 00:00:00