Abstract：
:The synergistic protective effect of nicorandil (KATP channel opener) and amlodipine (calcium channel blocker) on mitochondrial respiration and mitochondrial lipid contents were examined on isoproterenol-induced myocardial infarction in rats. The rats given isoproterenol (150 mg kg(-1) daily, i.p.) for 2 days showed significant changes in mitochondrial respiration and mitochondrial lipid profile levels. Pretreatment with nicorandil (2.5 mg kg(-1) daily, p.o.) and amlodipine (5.0 mg kg(-1) daily, p.o.) for 3 days significantly prevented these alterations and restored the mitochondrial respiration and mitochondrial lipid contents to near normal. Histopathological observations were also in correlation with the biochemical parameters. These findings indicate the synergistic protective effect of nicorandil and amlodipine on mitochondrial respiration and its membrane integrity during isoproterenol-induced cardiac damage.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Sathish V,Ebenezar KK,Devaki Tdoi
10.1016/s1043-6618(03)00223-8keywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
565-70issue
6eissn
1043-6618issn
1096-1186pii
S1043661803002238journal_volume
48pub_type
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