Abstract：
:Progressive neuronal death is the key pathogenic event leading to clinical symptoms in neurodegenerative disorders (NDDs). Neuroprotective treatments are virtually unavailable, partly because of the marked internal heterogeneity of the mechanisms underlying pathology. Targeted neuroprotection would require deep mechanistic knowledge across the entire aetiological spectrum of each NDD and the development of tailored treatments. Although ideal, this strategy appears challenging, as it would require a degree of characterization of both the disease and the patient that is currently unavailable. The alternate strategy is to search for commonalities across molecularly distinct NDD forms and exploit these for the development of drugs with broad-spectrum efficacy. In this view, mounting evidence points to ionic mechanisms (IMs) as targets with potential therapeutic efficacy across distinct NDD subtypes. The scope of this review is to present clinical and preclinical evidence supporting the link between disruption of IMs and neuronal death in specific NDDs and to critically revise past and ongoing attempts of harnessing IMs for the development of neuroprotective treatments.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Masi A,Narducci R,Mannaioni Gdoi
10.1016/j.phrs.2019.104343subject
Has Abstractpub_date
2019-09-01 00:00:00pages
104343eissn
1043-6618issn
1096-1186pii
S1043-6618(19)30782-0journal_volume
147pub_type
杂志文章,评审abstract：:Respiratory fluoroquinolones are currently considered by several guidelines among the most effective antimicrobial agents for the treatment of acute bacterial rhinosinusitis. The aim of this study was to assess levofloxacin penetration into paranasal sinuses mucosa of 15 patients with chronic rhinosinusitis 1h (n = 4)...
journal_title：Pharmacological research
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pub_type： 临床试验,杂志文章
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pub_type： 杂志文章
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journal_title：Pharmacological research
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更新日期：2002-12-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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pub_type： 杂志文章,meta分析,评审
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更新日期：2016-08-01 00:00:00
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更新日期：2002-10-01 00:00:00
