Abstract：
:Epidemiological studies support an inverse correlation between HDL-C and cardiovascular disease. However, low HDL-C levels do not always segregate with premature disease. These include, LCAT deficiency and the apolipoproteinA-IMilano (AIM) variant. AIM has a cysteine for arginine at position 173 in the otherwise cysteine free protein permitting AIM homodimerization and apoA-II heterodimerization. We relate the biochemical characteristics of low HDL-C phenotype AIM carriers to lipoprotein changes in humans administered recombinant dimeric AIM/palmitoyl-oleoyl phosphatidyl choline (ETC-216). Pharmacokinetic analysis of infused ETC-216 suggest a slow distribution of AIM into peripheral tissue and an extremely long terminal half-life in plasma. Following ETC-216 administration to normal human volunteers, an initial dose-dependent HDL-C elevation was observed. Thereafter, subjects transiently acquired a lipoprotein profile similar to that of AIM carriers, including reduced HDL-C and mild hypertriglyceridemia. The time-dependent changes in plasma lipids/lipoproteins may support an increased tissue cholesterol removing capacity of ETC-216. These findings provide mechanistic insight into the rapid removal of atheromatous plaques observed in humans, possibly linked to enhanced cholesterol removal capacity of ETC-216.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Bisgaier CL,Ackermann R,Rea T,Rodrigueza WV,Hartman Ddoi
10.1016/j.phrs.2016.05.001subject
Has Abstractpub_date
2016-09-01 00:00:00pages
86-99eissn
1043-6618issn
1096-1186pii
S1043-6618(15)30189-4journal_volume
111pub_type
杂志文章,随机对照试验abstract：:The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2004.11.007
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abstract：:In the present study, an attempt has been made to elucidate the role of alpha 2-adrenoceptors in reserpine-induced emesis in pigeons. Reserpine was found to induce dose-dependent emesis and a 500 micrograms kg-1 dose was found to be the 100% emetic dose. alpha 2-adrenoceptor agonists clonidine and alpha-methylnoradren...
journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
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pub_type： 临床试验,杂志文章
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journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2005.08.004
更新日期：2006-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,多中心研究
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更新日期：2019-03-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1006/phrs.1998.0382
更新日期：1998-11-01 00:00:00
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pub_type： 杂志文章
doi：10.1016/j.phrs.2016.02.016
更新日期：2016-04-01 00:00:00
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pub_type： 杂志文章
doi：10.1006/phrs.2000.0683
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1997.0188
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pub_type： 临床试验,杂志文章
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更新日期：1998-03-01 00:00:00
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pub_type： 杂志文章
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更新日期：2020-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2018-10-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2000-06-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2001-03-01 00:00:00
abstract：:The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succini...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0038
更新日期：1996-04-01 00:00:00
abstract：:Autism-spectrum disorder (ASD) is a neurodevelopmental disorder characterized by persistent deficits in social communication and repetitive patterns of behavior. ASD is, however, often associated with medical comorbidities and gastrointestinal (GI) dysfunction is among the most common. Studies have demonstrated a corr...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2018-06-01 00:00:00
