Abstract：
:Several studies on disease and treatment effects on neurohormones have been conducted with small numbers of patients, using one blood sample as representative of their states. The aim of this study was to assess the within-patient variability of plasma concentrations of several hormones and cytokines of recent interest, in patients with moderate heart failure and controlled stable background therapy over 3 weeks. Blood for neurohormone and cytokine assays was sampled in duplicate from 18 patients with moderate heart failure. After an initial visit, the patients were kept on stable therapy until the second blood sampling 21 +/- 3 days later. The plasma concentrations of several neurohormones (endothelin, renin, angiotensin II, aldosterone, norepinephrine) and cytokines (interleukin-6 (IL-6), interleukin-13 (IL-13), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF) and soluble receptor type I of tumour necrosis factor-alpha, (sTNF-RI) were measured with immunochemical methods. Some cytokines (IL-13, CNTF and LIF) were not detected. Despite clinically satisfactory ACE inhibition, circulating angiotensin II and aldosterone levels were still elevated in some patients, suggesting aldosterone escape. The between-visit agreement of plasma concentrations measured in duplicate was less than 35% for all circulating factors, except renin which showed a higher variability throughout the 3-week study period.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Masson S,Latini R,Bevilacqua M,Vago T,Sessa F,Torri M,Anesini A,Salio M,Pasotti E,Agnello D,Santoro L,Catania A,Ghezzi P,Moccetti T,Maggioni APdoi
10.1006/phrs.1998.0288subject
Has Abstractpub_date
1998-03-01 00:00:00pages
213-7issue
3eissn
1043-6618issn
1096-1186pii
S1043-6618(98)90288-2journal_volume
37pub_type
临床试验,杂志文章abstract：:The role of autophagy, a process in which the cell self-digests its own components, was investigated in glioma cell death induced by the hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase-inhibiting drug simvastatin. Induction of autophagy and activation of autophagy-regulating signalling pathways were analyzed by i...
journal_title：Pharmacological research
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pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2011.09.007
更新日期：2012-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 临床试验,杂志文章
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更新日期：2003-06-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2012-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：1994-08-01 00:00:00
abstract：:The molecular complexity of human breast cancer (BC) renders the clinical management of the disease challenging. Long non-coding RNAs (lncRNAs) are promising biomarkers for BC patient stratification, early detection, and disease monitoring. Here, we identified the involvement of the long intergenic non-coding RNA 0108...
journal_title：Pharmacological research
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