Natural products, extracts and formulations comprehensive therapy for the improvement of motor function in alcoholic liver disease.


:Alcoholic liver disease (ALD) is a major cause of chronic liver disease worldwide that afflicts human health. With the in-depth study of the disease, its pathogenesis has gradually become clear. Although great breakthroughs have been made in the research of ALD, the research and development of drugs related to ALD has lagged behind seriously. However, natural products have always inspired the development of drugs. Meanwhile, there is evidence that some natural products can also play a certain role in the treatment of ALD. Thus, we reviewed the natural products, extracts and formulations with potential anti-ALD activities by consulting the relevant data in the databases of PubMed, Web of Science and CNKI databases, in order to elucidate the regulated mechanism of these natural products. Sum up, the insights provided in present review will be needed for further exploration of botanical drugs in the development of ALD therapy.


Pharmacol Res


Pharmacological research


Hu S,Li SW,Yan Q,Hu XP,Li LY,Zhou H,Pan LX,Li J,Shen CP,Xu T




Has Abstract


2019-12-01 00:00:00












  • Loganin possesses neuroprotective properties, restores SMN protein and activates protein synthesis positive regulator Akt/mTOR in experimental models of spinal muscular atrophy.

    abstract::Spinal muscular atrophy (SMA) is an autosomal recessive neurodegenerative disease characterized by motor neurons degeneration and muscular atrophy. There is no effective SMA treatment. Loganin is a botanical candidate with anti-inflammatory, anti-oxidant, glucose-lowering and anti-diabetic nephropathy activities. The ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Tseng YT,Chen CS,Jong YJ,Chang FR,Lo YC

    更新日期:2016-09-01 00:00:00

  • Chasing c-Kit through the heart: Taking a broader view.

    abstract::Stem cell mediated cardiac repair is an exciting and controversial area of cardiovascular research that holds the potential to produce novel, revolutionary therapies for the treatment of heart disease. Extensive investigation to define cell types contributing to cardiac formation, homeostasis and regeneration has prod...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gude NA,Sussman MA

    更新日期:2018-01-01 00:00:00

  • Resveratrol plus ethanol counteract the ethanol-induced impairment of energy metabolism: ³¹P NMR study of ATP and sn-glycerol-3-phosphate on isolated and perfused rat liver.

    abstract::The effects of trans-resveratrol (RSV) combined with ethanol (EtOH) were evaluated by (31)P NMR on total ATP and sn-glycerol-3-phosphate (sn-G3P) contents measured in real time in isolated and perfused whole liver of the rat. Mitochondrial ATP turnover was assessed by using specific inhibitors of glycolytic and mitoch...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gallis JL,Serhan N,Gin H,Couzigou P,Beauvieux MC

    更新日期:2012-03-01 00:00:00

  • Haemodynamic effects of nisoldipine by oral route.

    abstract::The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

    更新日期:1991-10-01 00:00:00

  • Delivery routes for faecal microbiota transplants: Available, anticipated and aspired.

    abstract::Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

    更新日期:2020-09-01 00:00:00

  • Effect of praziquantel versus hycanthone on deoxyribonucleic acid content of hepatocytes in murine schistosomiasis mansoni.

    abstract::Cytophotometric measurement of the effect of praziquantel (500 mg/kg for 2 days) versus hycanthone (60 mg/kg for 3 days) on hepatocyte nuclear deoxyribonucleic acid (DNA) content was evaluated in Schistosoma mansoni infected mice. Drugs were given 8 weeks post-infection and repeated weekly for 4 weeks. DNA values of i...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Botros SS

    更新日期:1990-03-01 00:00:00

  • Genotoxicity and carcinogenicity studies of analgesics, anti-inflammatory drugs and antipyretics.

    abstract::This survey is a compendium of genotoxicity and carcinogenicity information of analgesics, anti-inflammatory drugs and antipyretics. Data from 120 drugs were collected; 109 of them are still in the market. Of these 120 drugs, 58 (48.3%) do not have retrievable genotoxicity or carcinogenicity data. The remaining 62 (51...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Brambilla G,Martelli A

    更新日期:2009-07-01 00:00:00

  • In vitro physiological evidence of enhanced antioxidant and neuroprotective action of 2,3-dihydromelatonin, a melatonin analogue.

    abstract::As the capacity of the endogenous antioxidative system is limited, pharmacological treatment with antioxidants may help to protect neuronal tissue against increased amount of reactive oxygen species produced during oxidative stress. We attempted to improve resistance of rat hippocampal slices exposed to ischaemia in v...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Gáspárová Z,Stolc S,Snirc V

    更新日期:2006-01-01 00:00:00

  • NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodies.

    abstract::Nerve growth factor (NGF) is the prototype of the neurotrophin family and promotes the survival of specific populations of neurons, stimulates their morphological differentiation and regulates neuronal gene expression. Since its discovery, NGF attracted clinicians for its potential application in the treatment of neur...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Lambiase A,Coassin M,Sposato V,Micera A,Sacchetti M,Bonini S,Aloe L

    更新日期:2007-07-01 00:00:00

  • Molecular modeling study on resistance of WT/D473H SMO to antagonists LDE-225 and LEQ-506.

    abstract::The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

    更新日期:2018-03-01 00:00:00

  • Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases.

    abstract::Mitochondria are best known for their role in ATP generation. However, studies over the past two decades have shown that mitochondria do much more than that. Mitochondria regulate both necrotic and apoptotic cell death pathways, they store and therefore coordinate cellular Ca2+ signaling, they generate and metabolize ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Joshi AU,Mochly-Rosen D

    更新日期:2018-12-01 00:00:00

  • Etrolizumab versus infliximab in the treatment of induction phase of ulcerative colitis: A systematic review and indirect comparison.

    abstract:OBJECTIVES:There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS...

    journal_title:Pharmacological research

    pub_type: 杂志文章,meta分析


    authors: Motaghi E,Ghasemi-Pirbaluti M,Zabihi M

    更新日期:2019-01-01 00:00:00

  • Anti-diabetic effects of Gymnema yunnanense extract.

    abstract::In this study, we evaluated anti-hyperglycemic effect and body weight reduction activity of Gymnema yunnanense extract in obese ob/ob and diabetic db/db mice. Animals received daily intraperitoneal injections of the extract 100 mg/kg for 12 days. On Day 5, the extract-treated ob/ob mice had significantly lower fasting...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xie JT,Wang A,Mehendale S,Wu J,Aung HH,Dey L,Qiu S,Yuan CS

    更新日期:2003-04-01 00:00:00

  • Effect of indomethacin on the kinetics of tumour necrosis factor alpha release and tumour necrosis factor alpha gene expression by human blood monocytes.

    abstract::In this investigation we have examined the effects of indomethacin, an inhibitor of the cyclooxygenase pathway of arachidonic acid, upon the kinetics of the release of tumour necrosis factor alpha (TNF) and of the expression of TNF gene by lipopolysaccharide (LPS)-stimulated human blood monocytes (BM). Following stimu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Spatafora M,Chiappara G,D'Amico D,Volpes D,Melis M,Pace E,Merendino A

    更新日期:1991-04-01 00:00:00

  • The development of medicines for children. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

    abstract::The lack of availability of appropriate medicines for children is an extensive and well known problem. As a consequence off label or unlicensed administration of medicinal products in every day paediatric practice is frequent. A variety of obstacles hinder the development of paediatric indications for drugs primarily ...

    journal_title:Pharmacological research

    pub_type: 社论,评审


    authors: Rocchi F,Tomasi P

    更新日期:2011-09-01 00:00:00

  • Bombycis corpus extract prevents amyloid-beta-induced cytotoxicity and protects superoxide dismutase activity in cultured rat astrocytes.

    abstract::Bombycis corpus(BC) or Bombyx Batryticatus, a batryticated silkworm and white-stiff silkworm, is a drug consisting of the dried larva of silkworm, Mobyz mori L., dead and stiffened due to the infection of Beauveria (Bals.) Vuill. In the present study, we have examined the protective effect of the water extracts agains...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Kim HJ,Lee WH,Yoon CH,Jeong JC,Nam KS,Kim HM,Choo YK,Lee MC,Kim CH

    更新日期:2001-01-01 00:00:00

  • Safety issues and harmful pharmacological interactions of nutritional supplements in Duchenne muscular dystrophy: considerations for Standard of Care and emerging virus outbreaks.

    abstract::At the moment, little treatment options are available for Duchenne muscular dystrophy (DMD). The absence of the dystrophin protein leads to a complex cascade of pathogenic events in myofibres, including chronic inflammation and oxidative stress as well as altered metabolism. The attention towards dietary supplements i...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Boccanegra B,Verhaart IEC,Cappellari O,Vroom E,De Luca A

    更新日期:2020-08-01 00:00:00

  • Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins.

    abstract::The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

    更新日期:2000-01-01 00:00:00

  • The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis.

    abstract::Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract. They are believed to be essential factors affecting host health. Most in vitro and ex vivo studies have shown that SCFAs affect the r...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Liu P,Wang Y,Yang G,Zhang Q,Meng L,Xin Y,Jiang X

    更新日期:2021-01-09 00:00:00

  • Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.

    abstract:BACKGROUND AND OBJECTIVES:Thymidylate synthase (TS) expression levels appear to be related to response to 5-fluorouracil-(5-FU)-based chemotherapy in colorectal cancer (CRC) patients. Three polymorphisms have been proposed as modulators of TS expression: a tandemly repeated sequence (2R/3R) in the 5' UTR, a SNP (G>C) w...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Vignoli M,Nobili S,Napoli C,Putignano AL,Morganti M,Papi L,Valanzano R,Cianchi F,Tonelli F,Mazzei T,Mini E,Genuardi M

    更新日期:2011-09-01 00:00:00

  • Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in Italy.

    abstract::Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

    更新日期:2005-03-01 00:00:00

  • Postmenopausal exogenous hormone therapy and Melanoma risk in women: A systematic review and time-response meta-analysis.

    abstract::A favourable option to management symptoms during menopausal transition is menopausal hormone therapy (MHT) but relation among MHT and risk of melanoma is controversial. This study aims to identify, analyse and present the evidence surrounding post-menopausal exogenous hormone therapy and the risk for melanoma in wome...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Tang X,Zhang H,Cui Y,Wang L,Wang Z,Zhang Y,Huo J,Cai J,Rinaldi G,Bhagavathula AS,Xiaopeng Y

    更新日期:2020-10-01 00:00:00

  • Bmi1 drives the formation and development of intrahepatic cholangiocarcinoma independent of Ink4A/Arf repression.

    abstract::Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are the most prevalent types of primary liver cancer. Compared with HCC, for which several drugs have been approved, ICC is associated with shorter survival, and no drug has been approved for this type. Previously, we reported that Bmi1 drives HC...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Guo J,Deng N,Xu Y,Li L,Kuang D,Li M,Li X,Xu Z,Xiang M,Xu C

    更新日期:2020-12-08 00:00:00

  • Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia.

    abstract::CHF5074 is a non-steroidal anti-inflammatory derivative holding disease-modifying potential for the treatment of Alzheimer's disease. The aim of the present study was to characterize the electrophysiological and metabolic profile of CHF5074 in the hippocampus. Electrophysiological recordings show that CHF5074 inhibits...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Mango D,Barbato G,Piccirilli S,Panico MB,Feligioni M,Schepisi C,Graziani M,Porrini V,Benarese M,Lanzillotta A,Pizzi M,Pieraccini S,Sironi M,Blandini F,Nicoletti F,Mercuri NB,Imbimbo BP,Nisticò R

    更新日期:2014-03-01 00:00:00

  • Influence of a 3-day regimen of azithromycin on the disposition kinetics of cyclosporine A in stable renal transplant patients.

    abstract::Some macrolide antibiotics have been shown to produce significant drug-drug interactions through the inhibition of cytochrome P450 (CYP) enzymes. In renal transplant patients these interactions pose potentially serious problems for the safe administration of cyclosporine A (CSA), a substrate of CYP3A4. The effects of ...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Bachmann K,Jauregui L,Chandra R,Thakker K

    更新日期:2003-06-01 00:00:00

  • Fostering efficacy and toxicity evaluation of traditional Chinese medicine and natural products: Chick embryo as a high throughput model bridging in vitro and in vivo studies.

    abstract::Efficacy and safety assessments are essential thresholds for drug candidates from preclinical to clinical research. Conventional mammalian in vivo models cannot offer rapid pharmacological and toxicological screening, whereas cell-based or cell-free in vitro systems often lead to inaccurate results because of the lack...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Wu T,Yu GY,Xiao J,Yan C,Kurihara H,Li YF,So KF,He RR

    更新日期:2018-07-01 00:00:00

  • Cost-effective pharmacological prevention of acute coronary syndromes.

    abstract::The growing size of trials on primary and secondary prevention of acute coronary syndromes characterised by very broad inclusion criteria may seem logical to 'trialists', who reason that the the broader the inclusion criteria, the easier it is to recruit large numbers of patients in a short period of time and the more...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Monaco C,Cianflone D,Summaria F,Maseri A,Crea F

    更新日期:1998-06-01 00:00:00

  • Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system.

    abstract::Epidemiological, clinical and animal studies revealed that sex differences exist in the manifestation and outcome of cardiovascular disease (CVD). The underlying molecular mechanisms implicated in these sex differences are not fully understood. The reasons for sex differences in CVD are definitely multifactorial, but ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Dworatzek E,Mahmoodzadeh S

    更新日期:2017-05-01 00:00:00

  • Statins decrease all-cause mortality only in CKD patients not requiring dialysis therapy--a meta-analysis of 11 randomized controlled trials involving 21,295 participants.

    abstract::The available studies have reported the benefits of statins on all-cause and cardiovascular mortality in chronic kidney disease (CKD) patients. However studies in end-stage renal disease patients on dialysis yielded conflicting results. Therefore, we performed a meta-analysis and provide the most reliable trial data t...

    journal_title:Pharmacological research

    pub_type: 杂志文章,meta分析


    authors: Barylski M,Nikfar S,Mikhailidis DP,Toth PP,Salari P,Ray KK,Pencina MJ,Rizzo M,Rysz J,Abdollahi M,Nicholls SJ,Banach M,Lipid and Blood Pressure Meta-Analysis Collaboration Group.

    更新日期:2013-06-01 00:00:00

  • Protein kinase C and alcohol addiction.

    abstract::Alcohol abuse and addiction are serious global health problems. Tackling these disorders requires an understanding of how ethanol produces its effects. Early cell culture studies implicated the protein kinase C (PKC) family of serine-threonine kinases in mediating both acute and chronic responses to ethanol exposure. ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Newton PM,Ron D

    更新日期:2007-06-01 00:00:00