Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

abstract：:The interaction of mianserin with ethanol in central nervous system (CNS) was investigated. Mianserin was administered at a single dose of 5 or 20 mgkg(-1) i.p. or as daily injections in a dose of 2.5 mgkg(-1) given for 14 days. The influence of mianserin on acute ethanol toxicity (LD(50)), on ED(50) of ethanol in rot...

journal_title：Pharmacological research

authors： Pietrzak B,Kubik-Bogucka E

更新日期：2002-07-01 00:00:00

abstract：:The neurohormonal factor arginine vasopressin (AVP) produces potent systemic vasoconstriction as well as water retention in the kidneys via the V(1a) and V(2) receptors, respectively. Therefore, AVP may be considered as an aggravating factor of cardiac failure. In the present study, the effects of intravenous (i.v.) i...

journal_title：Pharmacological research

authors： Yatsu T,Kusayama T,Tomura Y,Arai Y,Aoki M,Tahara A,Wada K,Tsukada J

更新日期：2002-11-01 00:00:00

abstract：:Extrasynaptically located γ-aminobutyric acid (GABA) receptors type A are often characterized by the presence of a δ subunit in the receptor complex. δ-Containing receptors respond to low ambient concentrations of GABA, or respond to spillover of GABA from the synapse, and give rise to tonic inhibitory currents. In ce...

journal_title：Pharmacological research

authors： Ahring PK,Bang LH,Jensen ML,Strøbæk D,Hartiadi LY,Chebib M,Absalom N

更新日期：2016-09-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (...

journal_title：Pharmacological research

authors： Mei D,Tan WSD,Liao W,Heng CKM,Wong WSF

更新日期：2020-11-01 00:00:00

abstract：:Endocannabinoids are part of a bioactive lipid signaling system, not only in the central nervous system but also in various peripheral organs. Accumulating evidence implicates dysregulation of the endocannabinoid system (ECS) in the pathogenesis of various cardiovascular diseases, including hypertension, atheroscleros...

journal_title：Pharmacological research

authors： Bátkai S,Pacher P

更新日期：2009-08-01 00:00:00

abstract：:In the last decade, the prevalence of autism spectrum disorders (ASD) has dramatically escalated worldwide. Currently available drugs mainly target some co-occurring symptoms of ASD, but are not effective on the core symptoms, namely impairments in communication and social interaction, and the presence of restricted a...

journal_title：Pharmacological research

authors： Pistollato F,Forbes-Hernández TY,Calderón Iglesias R,Ruiz R,Elexpuru Zabaleta M,Cianciosi D,Giampieri F,Battino M

更新日期：2020-02-01 00:00:00

abstract：:Hypercalcemia and hypercalciuria observed both in humans and in animals who were on long-term theophylline therapy, prompted us to investigate whether oral theophylline treatment at optimal doses causes any adverse side effects on bone metabolism in mild asthmatics. Therefore, serum osteocalcin (BGP) and total alkalin...

journal_title：Pharmacological research

authors： Oner P,Gürdöl F,Oner-Iyidon Y,Kolanci C,Büyüköztürk S

更新日期：1999-08-01 00:00:00

abstract：:Novel therapeutic strategies are needed to address and to solve the emerging problem of hypoxia-induced resistance to anticancer drugs. N-(4-Hydroxyphenyl)retinamide (4-HPR) exhibits potent anticancer and chemopreventive activities, but its inefficiency under hypoxia, through undetermined mechanisms, may contribute to...

journal_title：Pharmacological research

authors： Liu XW,Su Y,Zhu H,Cao J,Ding WJ,Zhao YC,He QJ,Yang B

更新日期：2010-11-01 00:00:00

abstract：:Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...

journal_title：Pharmacological research

authors： Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

更新日期：2001-03-01 00:00:00

abstract：:Aminoglycosides are very effective antibiotics for the treatment of severe infections, but they rank among the most frequent causes of drug-induced nephrotoxicity. Thus, prevention of aminoglycoside nephrotoxicity is an unmet therapeutic objective. Cardiotrophin-1 (CT-1), a member of the IL-6 family of cytokines, has ...

journal_title：Pharmacological research

authors： Quirós Y,Blanco-Gozalo V,Sanchez-Gallego JI,López-Hernandez FJ,Ruiz J,Perez de Obanos MP,López-Novoa JM

更新日期：2016-05-01 00:00:00

abstract：:A novel alkynylthiophene series of cannabinoid CB1 receptor antagonists has been described to exhibit distinct intrinsic activities with minimal substructure modifications. The three representatives, BPR0432, BPR0568 and BPR0569, functioning as a neutral antagonist, an inverse agonist and a partial agonist, respective...

journal_title：Pharmacological research

authors： Lin Y,Shia KS,Hsiao WC,Hsieh WP,Yeh TK,Tseng SL,Hsu CY,Chao YS,Hung MS

更新日期：2010-10-01 00:00:00

abstract：:There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

journal_title：Pharmacological research

authors： Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

更新日期：2016-09-01 00:00:00

abstract：:Dyslipidemia and hyperglycemia are associated with an increased risk of ischemic cardiovascular disease. Positive effects of a nutraceutical combination comprising red yeast rice, berberine, policosanol, astaxanthin, coenzyme Q10 and folic acid (NComb) on plasma lipid and glucose levels have been reported in some but ...

journal_title：Pharmacological research

authors： Pirro M,Mannarino MR,Bianconi V,Simental-Mendía LE,Bagaglia F,Mannarino E,Sahebkar A

更新日期：2016-08-01 00:00:00

abstract：:One of the most serious side effects of the immunosuppressive agent, cyclosporin A (CsA), is drug-related hypertension. As it is generally accepted, the sympathetic nervous system may play an important role in the development or maintenance of this abnormal pathophysiological situation. This study is aimed at assessin...

journal_title：Pharmacological research

authors： Reis F,Tavares P,Teixeira F

更新日期：2000-02-01 00:00:00

abstract：:Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

journal_title：Pharmacological research

authors： Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

更新日期：2020-09-01 00:00:00

abstract：AIM AND SCOPE:To determine the acute effects of increased intra-abdominal pressure (IAP) on the biochemistry, morphology, and contractility of the isolated terminal ileum of rats. BACKGROUND:Laparoscopic procedures are used clinically in diagnostic and treatment modalities and experimentally as a model of ischemia-rep...

journal_title：Pharmacological research

authors： Unsal MA,Imamoglu M,Kadioglu M,Aydin S,Ulku C,Kesim M,Alver A,Kalyoncu NI,Yaris E,Bozkaya H

更新日期：2006-02-01 00:00:00

abstract：:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses c...

journal_title：Pharmacological research

authors： Costa Queiroz RH,de Souza AM,Sampaio SV,Melchior E Jr

更新日期：2002-08-01 00:00:00

abstract：:A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...

journal_title：Pharmacological research

authors： Nishida K,Ohta Y,Ishiguro I

更新日期：1998-11-01 00:00:00

abstract：:Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine) are essential amino acids for humans and play an important role as the building blocks of proteins. Recent studies have disclosed that free BCAAs in the tissue amino acid pool function not only as substrates for protein synthesis, but also as regulato...

journal_title：Pharmacological research

authors： Shimomura Y,Kitaura Y

更新日期：2018-07-01 00:00:00

abstract：:The effect of the inhalation of vaporized ethanol on injected [1-14C]pyruvate kinetics was studied in mice. The [1-14C]pyruvate kinetics were modelled by means of a four-compartment closed model, i.e. injected site, blood, periphery and expired 14CO2. The results show that the inhalation of vaporized ethanol can stimu...

journal_title：Pharmacological research

authors： Wu G

更新日期：1998-01-01 00:00:00

abstract：:Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR. Unfortunately, due to the secondary mutation in EGFR, eventual drug-resistance is inevitable. Therefore, to overcome the resistance, new agent is urgen...

journal_title：Pharmacological research

authors： Xie YJ,Gao WN,Wu QB,Yao XJ,Jiang ZB,Wang YW,Wang WJ,Li W,Hussain S,Liu L,Leung EL,Fan XX

更新日期：2020-09-01 00:00:00

abstract：:Diabetic nephropathy (DN) is a common and serious complication of diabetes and causes kidney failure. Ginsenoside Rg5 (Rg5) is an important monomer in the main protopanaxadiol component of black ginseng. Rg5 has exhibited some beneficial biological effects, such as anti-cancer, neuroprotection, and anti-depression, bu...

journal_title：Pharmacological research

authors： Zhu Y,Zhu C,Yang H,Deng J,Fan D

更新日期：2020-05-01 00:00:00

abstract：:Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1997-12-01 00:00:00

abstract：:Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

journal_title：Pharmacological research

authors： Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

更新日期：2005-03-01 00:00:00

abstract：:This study investigated the impact of benzodiazepine receptor agonist, midazolam and antagonist, flumazenil, on the rat frontal cortex slices oxygen consumption (QO(2)), in presence and absence of gamma-aminobutyric acid (GABA). QO(2) was polarographically determined, using the biological oxygen monitor. As it was pre...

journal_title：Pharmacological research

authors： Obradović DI,Savić MM,Andjelković DS,Ugresić ND,Bokonjić DR

更新日期：2003-02-01 00:00:00

abstract：:It has demonstrated that carteolol can increase the endothelium-dependent vasodilation induced by alpha-2 adrenergic agonist. In order to evaluate the effect of carteolol, and to clarify the mechanism, we examined the effects of 10 microM carteolol on the vasodilation induced by increasing doses (10(-7)-10(-4) M) of c...

journal_title：Pharmacological research

authors： Ito M,Fukuda N,Izumi Y,Watanabe Y,Watanabe M,Soma M,Kanmatsuse K

更新日期：1995-05-01 00:00:00

abstract：:The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is n...

journal_title：Pharmacological research

authors： Fleming I

更新日期：2004-06-01 00:00:00

abstract：:Epidemiological studies suggest that diets with a high intake of vegetables and fruits may reduce the incidence of degenerative disorders including Alzheimer's disease. Berries are some of the popular fruits consumed worldwide. They are considered to be rich in anthocyanin pigments, a group belonging to the flavonoids...

journal_title：Pharmacological research

authors： Ramirez MR,Izquierdo I,do Carmo Bassols Raseira M,Zuanazzi JA,Barros D,Henriques AT

更新日期：2005-12-01 00:00:00

abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer researchers have developed many agents to target TRAIL and some of these agents have entered clinical trials in oncology. Unfortunatel...

journal_title：Pharmacological research

authors： Dianat-Moghadam H,Heidarifard M,Mahari A,Shahgolzari M,Keshavarz M,Nouri M,Amoozgar Z

更新日期：2020-05-01 00:00:00

abstract：:We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition me...

journal_title：Pharmacological research

authors： Winnicka MM,Braszko JJ,Wiśniewski K

更新日期：1997-11-01 00:00:00