Influence of mianserin on some central effects of ethanol.

abstract：:Tablets containing the inclusion complex of ursodeoxycholic acid (UDCA) with 2-hydroxypropyl-beta-cyclodextrin were prepared by direct compression. Plasma concentrations of UDCA were determined in six healthy volunteers after oral administration of tablets containing the inclusion complex or UDCA alone (Ursacol). Foll...

journal_title：Pharmacological research

authors： Panini R,Vandelli MA,Forni F,Pradelli JM,Salvioli G

更新日期：1995-03-01 00:00:00

abstract：:Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspen...

journal_title：Pharmacological research

authors： Ramos-Romero S,Pérez-Cano FJ,Ramiro-Puig E,Franch A,Castell M

更新日期：2012-09-01 00:00:00

abstract：:We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa multiple ascending dose study (0.25, 0.75, 2.0, and 6.0 mg/kg/day) enrolled 48 boys with Duchenne muscular dystrophy (4 to <7 years), with ...

journal_title：Pharmacological research

authors： Conklin LS,Damsker JM,Hoffman EP,Jusko WJ,Mavroudis PD,Schwartz BD,Mengle-Gaw LJ,Smith EC,Mah JK,Guglieri M,Nevo Y,Kuntz N,McDonald CM,Tulinius M,Ryan MM,Webster R,Castro D,Finkel RS,Smith AL,Morgenroth LP,Arrieta

更新日期：2018-10-01 00:00:00

abstract：:Steroids (aldosterone and testosterone) and peptides of cerebral origin (angiotensin II and the tachykinins) control the salt intake of the rat. They arouse or suppress the behaviour and produce life-long enhancements of NaCl intake. Need-induced salt intake (salt appetite or salt hunger), which is the consequence of ...

journal_title：Pharmacological research

authors： Epstein AN

更新日期：1992-02-01 00:00:00

abstract：:Some macrolide antibiotics have been shown to produce significant drug-drug interactions through the inhibition of cytochrome P450 (CYP) enzymes. In renal transplant patients these interactions pose potentially serious problems for the safe administration of cyclosporine A (CSA), a substrate of CYP3A4. The effects of ...

journal_title：Pharmacological research

authors： Bachmann K,Jauregui L,Chandra R,Thakker K

更新日期：2003-06-01 00:00:00

abstract：:A global transcriptional regulator, MgrA, was previously identified as a key determinant of virulence in Staphylococcus aureus. An 80% EtOH extract of Uncaria gambier was found to attenuate the virulence of S. aureus via its effects on MgrA. Using bioassay-guided fractionation, a polyphenolic polymer, uncariitannin, w...

journal_title：Pharmacological research

authors： Zhang H,Jiang JM,Han L,Lao YZ,Zheng D,Chen YY,Wan SJ,Zheng CW,Tan HS,Li ZG,Xu HX

更新日期：2019-09-01 00:00:00

abstract：:Alzheimer's is the neurodegenerative disease affecting the largest number of patients in the world. In spite of the intense research of the last decades, progress about its knowledge and therapy was limited. In particular, various cytotoxic processes remained debated, while the few drugs approved for therapy were of o...

journal_title：Pharmacological research

authors： Meldolesi J

更新日期：2019-08-01 00:00:00

abstract：:Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6....

journal_title：Pharmacological research

authors： Chae HJ,Kim SC,Chae SW,An NH,Kim HH,Lee ZH,Kim HR

更新日期：2001-03-01 00:00:00

abstract：:Green tea and its major polyphenols constituents, tea catechins, have been shown to have many health benefits including cancer prevention. Tea catechins and tea catechin metabolites/catabolites are bioavailable in the systemic circulation after oral intake of green tea or green tea catechins. The metabolites/catabolit...

journal_title：Pharmacological research

authors： Chow HH,Hakim IA

更新日期：2011-08-01 00:00:00

abstract：:We previously demonstrated that the typical mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) inhibited artery constriction, but CCCP was used only as a pharmacological tool. Niclosamide is an anthelmintic drug approved by FDA. Niclosamide ethanolamine (NEN) is a salt form of niclosamide and has ...

journal_title：Pharmacological research

authors： Li SL,Yan J,Zhang YQ,Zhen CL,Liu MY,Jin J,Gao JL,Xiao XL,Shen X,Tai Y,Hu N,Zhang XZ,Sun ZJ,Dong DL

更新日期：2017-01-01 00:00:00

abstract：:Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

journal_title：Pharmacological research

authors： Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

更新日期：2005-03-01 00:00:00

abstract：:Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are natu...

journal_title：Pharmacological research

authors： Lim DW,Park J,Jung J,Kim SH,Um MY,Yoon M,Kim YT,Han D,Lee C,Lee J

更新日期：2020-11-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is the third leading cause of death globally. Cumulative evidence has implicated renin-angiotensin system (RAS) in the pathogenesis of COPD. This study aimed to investigate potential protective effects of angiotensin II type-2 receptor (AT2R) activation in cigarette smoke (...

journal_title：Pharmacological research

authors： Mei D,Tan WSD,Liao W,Heng CKM,Wong WSF

更新日期：2020-11-01 00:00:00

abstract：:The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart and kidney homeostasis, but also plays an important role in the pathophysiology of heart and kidney diseases. Recently, new components of the RAS have been discovered, including angiotensin converting enzyme 2 (ACE2), Angiotensin(Ang)-(1-...

journal_title：Pharmacological research

authors： Simões E Silva AC,Teixeira MM

更新日期：2016-05-01 00:00:00

abstract：:There is considerable evidence to support the role of anandamide (AEA), an endogenous ligand of cannabinoid receptors, in neuropathic pain modulation. AEA also produces effects mediated by other biological targets, of which the transient receptor potential vanilloid type 1 (TRPV1) has been the most investigated. Both,...

journal_title：Pharmacological research

authors： Malek N,Kostrzewa M,Makuch W,Pajak A,Kucharczyk M,Piscitelli F,Przewlocka B,Di Marzo V,Starowicz K

更新日期：2016-09-01 00:00:00

abstract：:To assess the potential role of vasoactive cardiac eicosanoids in the modulation of coronary flow, we measure thromboxane(TX)B2, 6-keto-prostaglandin(PG)F1 alpha, PGE2 and sulphido-peptide leukotrienes (LTC4, D4, E4) in the coronary effluent of isolated perfused rat heart in both baseline and post-ischaemic conditions...

journal_title：Pharmacological research

authors： Giannessi D,Lazzerini G,Sicari R,DeCaterina R

更新日期：1992-12-01 00:00:00

abstract：:Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified ...

journal_title：Pharmacological research

authors： Ramello MC,Haura EB,Abate-Daga D

更新日期：2018-03-01 00:00:00

abstract：:Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic accompany with metabolic and endocrine disorders worldwide. Most of DM patients are affected by type 2 diabetes mellitus (T2DM) with insulin resistance and insulin secretion defect. Generally, the strategies to treat T2DM are diet...

journal_title：Pharmacological research

authors： Xu L,Li Y,Dai Y,Peng J

更新日期：2018-04-01 00:00:00

abstract：:Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

journal_title：Pharmacological research

authors： Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

更新日期：1989-03-01 00:00:00

abstract：:The rationale underlying therapeutic strategies designed to inhibit the action of endogenous sex hormones in malignant breast cells is provided by the demonstration of their involvement in supporting the development and growth of breast carcinoma. The surgical removal of steroid-secreting glands, in order to reduce th...

journal_title：Pharmacological research

authors： de Cupis A,Schettini G,Favoni RE

更新日期：1999-05-01 00:00:00

abstract：:We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

journal_title：Pharmacological research

authors： Campos BG,Ferreira RR,Gomes JC

更新日期：2000-03-01 00:00:00

abstract：:The aim of this study was to investigate the effects of manganese chloride on gentamicin-induced nephrotoxicity in rats. Thirty-six adult Wistar Albino rats were divided into six equal groups. They were injected with gentamicin sulfate (100 mg kg(-1) per day i.p.) and manganese chloride (2 or 20 mg kg(-1) per day i.p....

journal_title：Pharmacological research

authors： Ateşşahin A,Karahan I,Yilmaz S,Ceribaşi AO,Princci I

更新日期：2003-12-01 00:00:00

abstract：:Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

journal_title：Pharmacological research

authors： Furlanut M,Benetello P

更新日期：1990-01-01 00:00:00

abstract：INTRODUCTION:Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the func...

journal_title：Pharmacological research

authors： Silva DF,Wenceslau CF,Mccarthy CG,Szasz T,Ogbi S,Webb RC

更新日期：2019-09-01 00:00:00

abstract：:Idiopathic pulmonary fibrosis (IPF) is a debilitating condition where excess collagen deposition occurs in the extracellular matrix. At first sight, it is expected that the level of different kinds of matrix metalloproteinases might be downregulated in IPF as it is a matrix degrading collagenase. However, the role of ...

journal_title：Pharmacological research

authors： Mahalanobish S,Saha S,Dutta S,Sil PC

更新日期：2020-02-01 00:00:00

abstract：:PI3K was originally discovered as a lipid kinase involved in the phosphorylation of the inositol ring in position -3, leading to the synthesis of phosphatidyl-inositol-3-4 bisphosphate. The enzyme purified from rat liver is an heterodimer of two subunits of 85 and 110 KD respectively: it phosphorylates the D3 hydroxyl...

journal_title：Pharmacological research

authors： Chiarugi V

更新日期：1997-04-01 00:00:00

abstract：:The polyphenol resveratrol is considered to exert many beneficial actions, such as antioxidant, anti-inflammatory, insulin-sensitizer and anticancer effects. Its benefits in patients with type 2 diabetes mellitus (T2DM) are controversial. Our aims were to determine whether resveratrol supplementation at two different ...

journal_title：Pharmacological research

authors： Bo S,Ponzo V,Ciccone G,Evangelista A,Saba F,Goitre I,Procopio M,Pagano GF,Cassader M,Gambino R

更新日期：2016-09-01 00:00:00

abstract：:Postnatal bone marrow contains a subtype of unique progenitor cells that have the capacity to differentiate into functional endothelial cells. Hence, these cells have been termed endothelial progenitor cells (EPCs). In general, circulating EPCs were characterized by the expression of CD133, CD34 and the vascular endot...

journal_title：Pharmacological research

authors： Hristov M,Weber C

更新日期：2008-08-01 00:00:00

abstract：:Cytochrome P450-dependent arachidonic acid (AA) metabolism by medullary thick ascending limb of the loop of Henle (mTALH) cells, corneal epithelium and other transporting epithelia, such as those of the intestines, generate metabolites which affect Na(+)-K(+)-ATPase activity, vasomotion and, thereby, organ function. F...

journal_title：Pharmacological research

authors： Carroll MA,Quilley CP,McGiff JC

更新日期：1991-05-01 00:00:00

abstract：:The smoothened (SMO) receptor, an essential signal transducer in the Hedgehog pathway, was targeted with antagonists to suppress the tumor. It is interesting that SMO D473H mutation confers resistance on inhibitor LDE-225 rather than LEQ-506. In this paper, the binding modes of them against the wild type and mutant SM...

journal_title：Pharmacological research

authors： Tu J,Li JJ,Song LT,Zhai HL,Wang J,Zhang XY

更新日期：2018-03-01 00:00:00