Matrix metalloproteinase: An upcoming therapeutic approach for idiopathic pulmonary fibrosis.

abstract：:The anti-inflammatory effect of glucocorticoids depends, at least in part, on the induction of two regulatory proteins, lipocortin and vasocortin, both preventing the release of inflammatory mediators. Lipocortin inhibits phospholipase A2 (PLA2) and therefore reduces arachidonic acid metabolites formation. Vasocortin ...

journal_title：Pharmacological research

authors： Sautebin L,Carnuccio R,Ialenti A,Di Rosa M

更新日期：1992-01-01 00:00:00

abstract：:The vascular endothelial growth factor receptor-1 (VEGFR-1) is a membrane receptor for VEGF-A, placenta growth factor (PlGF) and VEGF-B that plays a crucial role in melanoma invasiveness, vasculogenic mimicry and tumor-associated angiogenesis. Furthermore, activation of VEGFR-1 is involved in the mobilization of myelo...

journal_title：Pharmacological research

authors： Lacal PM,Atzori MG,Ruffini F,Scimeca M,Bonanno E,Cicconi R,Mattei M,Bernardini R,D'Atri S,Tentori L,Graziani G

更新日期：2020-09-01 00:00:00

abstract：:Diabetes mellitus is associated with both microvascular and macrovascular complications, which can result in visceral aneurysms as for example splenic artery aneurysms: in their management, an endovascular treatment, less invasive than surgery, is generally preferred. Endovascular treatment of splenic artery aneurysms...

journal_title：Pharmacological research

authors： Venturini M,Marra P,Colarieti A,Agostini G,Lanza C,Augello L,Gusmini S,Salvioni M,Melissano G,Fiorina P,Chiesa R,De Cobelli F,Del Maschio A

更新日期：2018-09-01 00:00:00

abstract：:Exposure to ionizing radiation causes damage to living tissues; however, only a small number of agents have been approved for use in radiation injuries. Radioprotector is the primary countermeasure to radiation injury and none radioprotector has indeed reached the drug development stage. Repurposing the long list of a...

journal_title：Pharmacological research

authors： Ren L,Xie D,Li P,Qu X,Zhang X,Xing Y,Zhou P,Bo X,Zhou Z,Wang S

更新日期：2016-11-01 00:00:00

abstract：:The antitumour and immunosuppressive activities of spermine dialdehyde (SDA), a synthetic, oxidized form of spermine, were examined using L1210 cell lines and murine bone marrow cells. SDA acted as a high affinity substrate for aldehyde dehydrogenase (ADH) derived from different sources, with kinetic profiles similar ...

journal_title：Pharmacological research

authors： Kazmi SM,Li D,Koop K,Conant J,Lau CY

更新日期：1992-05-01 00:00:00

abstract：:Beta-endorphin/beta-lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain p...

journal_title：Pharmacological research

authors： Salar G,Alessio L,Govoni S,Battaini F,Iob I,Goss I,Trabucchi M

更新日期：1991-02-01 00:00:00

abstract：:Gastrointestinal toxicity and red skin discoloration were the major side effects observed in leprosy patients undergoing long-term treatment with clofazimine (CFZ). Hematological and biochemical alterations have been cited among other side effects; however, their real magnitude and clinical significance at the doses c...

journal_title：Pharmacological research

authors： Costa Queiroz RH,de Souza AM,Sampaio SV,Melchior E Jr

更新日期：2002-08-01 00:00:00

abstract：:It has demonstrated that carteolol can increase the endothelium-dependent vasodilation induced by alpha-2 adrenergic agonist. In order to evaluate the effect of carteolol, and to clarify the mechanism, we examined the effects of 10 microM carteolol on the vasodilation induced by increasing doses (10(-7)-10(-4) M) of c...

journal_title：Pharmacological research

authors： Ito M,Fukuda N,Izumi Y,Watanabe Y,Watanabe M,Soma M,Kanmatsuse K

更新日期：1995-05-01 00:00:00

abstract：:Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-beta-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to influence halothane...

journal_title：Pharmacological research

authors： Harrison GG,Dyer RA,Llewellyn RL,James MF

更新日期：1999-02-01 00:00:00

abstract：:An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

journal_title：Pharmacological research

authors： Giacobini E

更新日期：2004-10-01 00:00:00

abstract：:In hypothermic rats with acute hypertension induced by intravenous injection of adrenalin, regional changes in blood-brain barrier permeability to macromolecules were investigated using Evans blue as indication. Evans blue albumin extravasation was determined as a macroscopic finding and a quantitative estimation with...

journal_title：Pharmacological research

authors： Oztaş B,Kaya M,Camurcu S

更新日期：1992-07-01 00:00:00

abstract：:The review emphasizes the role of NGF, the most representative member of the neurotrophins family, in cardiac physiopathology with a particular focus on healing and sprouting processes occurring after tissue damage. Cardiac and circulating NGF levels dramatically increase following myocardial injury (MI). A very early...

journal_title：Pharmacological research

authors： Govoni S,Pascale A,Amadio M,Calvillo L,D'Elia E,Cereda C,Fantucci P,Ceroni M,Vanoli E

更新日期：2011-04-01 00:00:00

abstract：:Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptome analysis, we comp...

journal_title：Pharmacological research

authors： Chen Y,Brooks MJ,Gieser L,Swaroop A,Palczewski K

更新日期：2017-01-01 00:00:00

abstract：:Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which is a hallmark of cancer. The altered energy metabolism not only provides cancer cell with ATP for cellular energy, but also generate essen...

journal_title：Pharmacological research

authors： Abdel-Wahab AF,Mahmoud W,Al-Harizy RM

更新日期：2019-12-01 00:00:00

abstract：:The mechanisms involved in enhanced cough induced by central and inhaled NGF in guinea pigs were investigated. Cough and airway function were assessed by plethysmography following inhaled or intracerebroventricular (i.c.v.) NGF treatment. Expression of TrkA and/or TRPV1 was determined in bronchi and/or brainstem by re...

journal_title：Pharmacological research

authors： El-Hashim AZ,Jaffal SM,Al-Rashidi FT,Luqmani YA,Akhtar S

更新日期：2013-08-01 00:00:00

abstract：:The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

journal_title：Pharmacological research

authors： Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

更新日期：1999-11-01 00:00:00

abstract：:Cytophotometric measurement of the effect of praziquantel (500 mg/kg for 2 days) versus hycanthone (60 mg/kg for 3 days) on hepatocyte nuclear deoxyribonucleic acid (DNA) content was evaluated in Schistosoma mansoni infected mice. Drugs were given 8 weeks post-infection and repeated weekly for 4 weeks. DNA values of i...

journal_title：Pharmacological research

authors： Botros SS

更新日期：1990-03-01 00:00:00

abstract：:Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

journal_title：Pharmacological research

authors： Csaba G,Kovács P,Pállinger E

更新日期：2003-11-01 00:00:00

abstract：:Contrasting results have been reported on the role of rs628031 and rs683369 polymorphisms of SLC22A1 and rs776746 of CYP3A5 on imatinib treatment response in patients with chronic myeloid leukemia (CML). In the present study, we conducted a systematic review and meta-analysis of published studies to estimate the impac...

journal_title：Pharmacological research

authors： Cargnin S,Ravegnini G,Soverini S,Angelini S,Terrazzino S

更新日期：2018-05-01 00:00:00

abstract：:Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...

journal_title：Pharmacological research

authors： Fraser CM,Sills GJ,Forrest G,Thompson GG,Brodie MJ

更新日期：1999-09-01 00:00:00

abstract：:Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patient...

journal_title：Pharmacological research

authors： Ahaneku JE,Sakata K,Urano T,Takada Y,Takada A

更新日期：2000-01-01 00:00:00

abstract：:A simple method for solubilization and reconstitution of the A1 adenosine receptor from bovine brain is presented. Solubilization with CHAPS-phosphatidylcholine (CHAPS/PC) mixture did not alter the binding properties of the A1 adenosine receptor antagonist [3H]-DPCPX. The solubilized receptors were chromatographed on ...

journal_title：Pharmacological research

authors： Ragazzi E,Shryock J,Palczewski K

更新日期：1991-07-01 00:00:00

abstract：:TMEM16A plays critical roles in physiological process and may serve as drug targets for diverse diseases. Recently, TMEM16A has started to be regarded as potential primary lung adenocarcinoma targets. Here, we identified that arctigenin, a natural compound, is a novel TMEM16A inhibitor, and it can suppress lung adenoc...

journal_title：Pharmacological research

authors： Guo S,Chen Y,Shi S,Wang X,Zhang H,Zhan Y,An H

更新日期：2020-05-01 00:00:00

abstract：:The effects of the angiotensin-converting enzyme (ACE) inhibitor monopril and the angiotensin II receptor blocker losartan on serum glucose, protein levels and some serum lipid components were compared in normal and diabetic rats receiving oral antidiabetic drugs 'repaglinide or gliclazide'. The two antihypertensive a...

journal_title：Pharmacological research

authors： el-Batran SA,el-Shenawy SM,Nofal SM,Abdel-Salam OM,Arbid MS

更新日期：2004-08-01 00:00:00

abstract：:Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size des...

journal_title：Pharmacological research

authors： Gaborit B,Moulin PA,Bege T,Boullu S,Vincentelli C,Emungania O,Morange PE,Berdah S,Salem JE,Dutour A,Frere C

更新日期：2018-05-01 00:00:00

abstract：:Fish represent the oldest and most diverse classes of vertebrates, comprising around the 48% of the known member species in the subphylum Vertebrata. There are many scientific fields that use fish as models in research, including respiratory and cardiovascular research, cell culture, ecotoxicology, ageing, pharmacolog...

journal_title：Pharmacological research

authors： Bolis CL,Piccolella M,Dalla Valle AZ,Rankin JC

更新日期：2001-10-01 00:00:00

abstract：:Vaccinations have been used as an essential tool in the fight against infectious diseases, and succeeded in improving public health. However, adverse effects, including autoimmune conditions may occur following vaccinations (autoimmune/inflammatory syndrome induced by adjuvants--ASIA syndrome). It has been postulated ...

journal_title：Pharmacological research

authors： Soriano A,Nesher G,Shoenfeld Y

更新日期：2015-02-01 00:00:00

abstract：:The cytokine thymic stromal lymphopoietin (TSLP) is involved in the development and the progression of allergic diseases. It is mainly released by epithelial cells at barriers such as skin and gut in response to danger signals. Overexpression of TSLP in keratinocytes (KC) can provoke the development of a type 2 inflam...

journal_title：Pharmacological research

authors： Schaper K,Rossbach K,Köther B,Stark H,Kietzmann M,Werfel T,Gutzmer R

更新日期：2016-11-01 00:00:00

abstract：:Metastatic melanoma has been described as a highly aggressive cancer with low sensibility to chemotherapeutic agents. New types of drug, such as metal-based drugs (ferrocifens) have emerged and could represent an alternative for melanoma treatment since they show interesting anticancer potential. Furthermore, molecula...

journal_title：Pharmacological research

authors： Resnier P,Galopin N,Sibiril Y,Clavreul A,Cayon J,Briganti A,Legras P,Vessières A,Montier T,Jaouen G,Benoit JP,Passirani C

更新日期：2017-12-01 00:00:00

abstract：:The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyruvic acid, succinic acid and glutamic acid. The meglitinide a...

journal_title：Pharmacological research

authors： Bakkali Nadi A,Zhang TM,Malaisse WJ

更新日期：1996-03-01 00:00:00