Fish as model in pharmacological and biological research.


:Fish represent the oldest and most diverse classes of vertebrates, comprising around the 48% of the known member species in the subphylum Vertebrata. There are many scientific fields that use fish as models in research, including respiratory and cardiovascular research, cell culture, ecotoxicology, ageing, pharmacological and genetic studies.


Pharmacol Res


Pharmacological research


Bolis CL,Piccolella M,Dalla Valle AZ,Rankin JC





Has Abstract


2001-10-01 00:00:00














  • Pharmacological studies of cardamom oil in animals.

    abstract::Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: al-Zuhair H,el-Sayeh B,Ameen HA,al-Shoora H

    更新日期:1996-07-01 00:00:00

  • Fenofibrate and dipyridamole treatments in low-doses either alone or in combination blunted the development of nephropathy in diabetic rats.

    abstract::Low-doses of fenofibrate and dipyridamole have pleiotropic renoprotective actions in diabetic rats. This study investigated their combined effect relative to their individual treatments and lisinopril in rats with diabetic nephropathy. Streptozotocin (55mg/kg, i.p., once)-administered diabetic rats were allowed for 10...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Balakumar P,Varatharajan R,Nyo YH,Renushia R,Raaginey D,Oh AN,Akhtar SS,Rupeshkumar M,Sundram K,Dhanaraj SA

    更新日期:2014-12-01 00:00:00

  • The influence of divalent cations on the analgesic effect of opioid and non-opioid drugs.

    abstract::It is generally accepted that divalent cations are involved in the nociceptive pathway. The effect of systemic co-administration of magnesium sulfate and calcium channel blockers (nifedipine, verapamil) on the analgesic effect of opioid (mixed mu/kappa: butorphanol) and non-opioid drugs (paracetamol) was investigated....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Assi AA

    更新日期:2001-06-01 00:00:00

  • The influence of simvastatin on lipase and cholesterol esterase activity in the serum of men with coronary heart disease.

    abstract::Several studies have demonstrated that any beneficial effects of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins), of which simvastatin (Merck Sharp & Dohme) is an example, on coronary events are linked to their hypocholesterolemic properties. The in vivo effects of simvastatin treatment ...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Pioruńska-Stolzmann M,Pioruńska-Mikołajczak A

    更新日期:2001-04-01 00:00:00

  • Pharmacokinetics of fructose-1,6-diphosphate after intraperitoneal and oral administration to adult rats.

    abstract::Exogenously administered fructose-1,6-diphosphate (FDP) has been studied for its ability to protect tissue during hypoxia or ischemia. Recently, a clear effect of FDP on the central nervous system has raised the question whether FDP can get into the brain. FDP levels were measured in blood, brain, liver, kidney, muscl...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Xu K,Stringer JL

    更新日期:2008-03-01 00:00:00

  • Modification of reserpine-induced emetic response in pigeons by alpha 2-adrenoceptors.

    abstract::In the present study, an attempt has been made to elucidate the role of alpha 2-adrenoceptors in reserpine-induced emesis in pigeons. Reserpine was found to induce dose-dependent emesis and a 500 micrograms kg-1 dose was found to be the 100% emetic dose. alpha 2-adrenoceptor agonists clonidine and alpha-methylnoradren...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Khandker SK,Mukerjee D,Gurtu S,Pant KK,Dhawan KN,Sinha JN

    更新日期:1994-05-01 00:00:00

  • Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in Italy.

    abstract::Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

    更新日期:2005-03-01 00:00:00

  • Pharmacogenomic analyzis of the responsiveness of gastrointestinal tumor cell lines to drug therapy: A transportome approach.

    abstract::In this study, we have addressed the pharmacogenomic basis of the response of gastrointestinal tumors to six anticancer drugs using a panel of fifteen cell lines derived from pancreatic, stomach and biliary tract cancers. We determined the constitutive expression levels of 96 genes, whose encoded proteins contribute t...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Grañé-Boladeras N,Pérez-Torras S,Lozano JJ,Romero MR,Mazo A,Marín JJG,Pastor-Anglada M

    更新日期:2016-11-01 00:00:00

  • Inhibition of the NANC relaxation of the guinea-pig proximal colon longitudinal muscle by the purinoceptor antagonist PPADS, inhibition of nitric oxide synthase, but not by a PACAP/VIP antagonist.

    abstract::The effects of the P(2)-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl- 2('),4(')- disulphonic acid (PPADS), the nitric oxide (NO) synthase inhibitor N(G)-nitro- l -arginine (l -NOARG), the K(+)-channel blocker apamin, the pituitary adenylate cyclase activating peptide (PACAP) antagonist PACAP(6-38) and the s...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Rózsai B,Lázár Z,Benkó R,Barthó L

    更新日期:2001-01-01 00:00:00

  • Palmitoylation in Alzheimer's disease and other neurodegenerative diseases.

    abstract::Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulati...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Cho E,Park M

    更新日期:2016-09-01 00:00:00

  • The effect of ginseng on bile-pancreatic secretion in the rat. Increase in proteins and inhibition of total lipids and cholesterol secretion.

    abstract::Ginseng is one of the most popular herbal remedies. Studies were performed in anaesthetized rats to examine the effect of ginseng on bile secretion. Male Sprague-Dawley rats were anaesthetized with intraperitoneal (i.p.) urethane (1.25 g kg(-1)) and equipped with biliary cannulas inserted into the bile duct through th...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Salam OM,Nada SA,Arbid MS

    更新日期:2002-04-01 00:00:00

  • Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus.

    abstract::Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

    更新日期:2017-03-01 00:00:00

  • Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications.

    abstract::Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In th...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Genario R,Cipolla-Neto J,Bueno AA,Santos HO

    更新日期:2021-01-01 00:00:00

  • Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression.

    abstract::The suppression of the abnormal systemic immune response constitutes a primary strategy for treatment of rheumatoid arthritis (RA); toward this end, the identification of natural compounds with immunosuppressive activity represents a promising strategy for RA drug discovery. Cinnamtannin D1 (CTD-1), a polyphenolic com...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Shi C,Zhang H,Wang X,Jin B,Jia Q,Li Y,Yang Y

    更新日期:2020-01-01 00:00:00

  • Influence of PLA2-PG system on purine release and cAMP content in dissociated primary glial cultures from rat striatum.

    abstract::Purine release and prostaglandin (PG) outflow were simultaneously evaluated from untreated glial primary cultures of rat striatum, at rest and under field electrical stimulation. Purine release was also assayed from sister cultured cells in which a suitable pharmacological treatment with 1 x 10(-6) M dexamethasone or ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Caciagli F,Ciccarelli R,Di Iorio P,Tacconelli L,Ballerini P

    更新日期:1989-05-01 00:00:00

  • Behavioural activity of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors.

    abstract::The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly att...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zalewska-Wińska A,Wiśniewski K

    更新日期:2000-09-01 00:00:00

  • Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.

    abstract::Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present study investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial infarction given specifically at reperfusion and the signalling pathway involved. Thiobutabarb...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Karwi QG,Whiteman M,Wood ME,Torregrossa R,Baxter GF

    更新日期:2016-09-01 00:00:00

  • Pharmacokinetics of resveratrol metabolic profile in healthy humans after moderate consumption of red wine and grape extract tablets.

    abstract::A pharmacokinetic study of the metabolic profile of resveratrol has been performed in healthy men after moderate red wine (RW) consumption. The bioavailability of resveratrol is highly influenced by several factors such as the food matrix and, therefore, this study has been compared with a pilot study in which men ing...

    journal_title:Pharmacological research

    pub_type: 杂志文章,随机对照试验


    authors: Rotches-Ribalta M,Andres-Lacueva C,Estruch R,Escribano E,Urpi-Sarda M

    更新日期:2012-11-01 00:00:00

  • Viral G protein-coupled receptors as modulators of cancer hallmarks.

    abstract::Herpesviruses encode transmembrane G protein-coupled receptors (GPCRs), which share structural homology to human chemokine receptors. These viral GPCRs include KSHV-encoded ORF74, EBV-encoded BILF1, and HCMV-encoded US28, UL33, UL78 and US27. Viral GPCRs hijack various signaling pathways and cellular networks, includi...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: van Senten JR,Fan TS,Siderius M,Smit MJ

    更新日期:2020-06-01 00:00:00

  • Cocoa intake attenuates oxidative stress associated with rat adjuvant arthritis.

    abstract::Cocoa contains flavonoids with antioxidant properties. The aim of this study was to ascertain the effect of cocoa intake on oxidative stress associated with a model of chronic inflammation such as adjuvant arthritis. Female Wistar rats were fed with a 5% or 10% cocoa-enriched diet or were given p.o. a quercetin suspen...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ramos-Romero S,Pérez-Cano FJ,Ramiro-Puig E,Franch A,Castell M

    更新日期:2012-09-01 00:00:00

  • Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions.

    abstract::The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Jeong HJ,Yi JM,Hong SH,Kong JY,Kim KS,Won JH,Cho KH,Shin TY,Kim HS,Kim HM

    更新日期:2002-11-01 00:00:00

  • Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain.

    abstract:BACKGROUND AND PURPOSE:The enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) hydrolyze endogenous cannabinoids (eCBs), N-arachidonoyl ethanolamine (AEA) and 2-arachidonoyl glycerol (2-AG), respectively. These enzymes also metabolize eCB analogs such as lipoamines and 2-acyl glycerols, most of...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Leishman E,Cornett B,Spork K,Straiker A,Mackie K,Bradshaw HB

    更新日期:2016-08-01 00:00:00

  • A2BP1 gene polymorphisms association with olanzapine-induced weight gain.

    abstract::The ataxin-2 binding protein 1 (A2BP1) gene is reported to be one of the susceptibility genes in schizophrenia, autism, and obesity. The aim of this study was to explore the association of A2BP1 gene polymorphisms with antipsychotic induced weight gain (AIWG) in Chinese Han population. Three hundred and twenty-eight p...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Dong L,Yan H,Huang X,Hu X,Yang Y,Ma C,Du B,Lu T,Jin C,Wang L,Yu H,Dong Z,Li W,Ruan Y,Zhang H,Zhang H,Mi W,Ma W,Li K,Lv L,Zhang D,Yue W

    更新日期:2015-09-01 00:00:00

  • L-histidine/medroxyprogesterone acetate interaction modulates human breast cancer cell growth and progestin receptor expression in vitro.

    abstract::The effect of different L-histidine concentrations on human mammary tumour cell (CG5) proliferation was studied to test the hypothesis of a role of histidine in modulating sex steroid-regulated cell proliferation. Cell growth was only possible in the 10(-5) M and 10(-2) M range, while its inhibition by medroxyprogeste...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ghezzo F,Racca S,Conti G,Berta GN,D'Avolio A,Abbadessa G,Gambino G,Di Carlo F

    更新日期:1997-02-01 00:00:00

  • P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387.

    abstract::CYT387 is an orally bioavailable, small molecule inhibitor of Janus family of tyrosine kinases (JAK) 1 and 2. It is currently undergoing Phase I/II clinical trials for the treatment of myelofibrosis and myeloproliferative neoplasms. We aimed to establish whether the multidrug efflux transporters P-glycoprotein (P-gp; ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Durmus S,Xu N,Sparidans RW,Wagenaar E,Beijnen JH,Schinkel AH

    更新日期:2013-10-01 00:00:00

  • Calumenin and fibulin-1 on tumor metastasis: Implications for pharmacology.

    abstract::Tumor metastasis is a key cause of cancer mortality, and inhibiting migration of cancer cells is one of the major directions of anti-metastatic drug development. Calumenin and fibulin-1 are two extracellular proteins that synergistically inhibit cell migration and tumor metastasis, and could potentially be served as t...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zheng P,Wang Q,Teng J,Chen J

    更新日期:2015-09-01 00:00:00

  • Chaperones in autophagy.

    abstract::Cells continuously turn over proteins through cycles of synthesis and degradation in order to maintain a functional proteome and to exert a tight control in the levels of regulatory proteins. Selective degradation of proteins was initially thought to be an exclusive function of the ubiquitin-proteasome system, however...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kaushik S,Cuervo AM

    更新日期:2012-12-01 00:00:00

  • The pharmacoeconomic impact of amlodipine use on coronary artery disease.

    abstract::The most frequent cause of mortality and morbidity in industrialized countries is coronary artery disease (CAD), which in Europe alone is responsible for around two million deaths per year. In 2001 it accounted for about 260,000 hospital discharges in Italy. The costs of CAD treatment in Italy--which were borne by the...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: De Portu S,Menditto E,Scalone L,Bustacchini S,Cricelli C,Mantovani LG

    更新日期:2006-08-01 00:00:00

  • Exogenous insulin-like growth factor (IGF)-1 improves the impaired healing of gastric mucosal lesions in diabetic rats.

    abstract:BACKGROUND:We examined the influence of diabetes mellitus (DM) on the healing of HCl-induced gastric lesions and the healing promoting effect of IGF-1 on these lesions. METHODS:Experiments were performed on rats injected with streptozotocin (STZ, 70 mg kg(-1), i.p.) 5 weeks prior to the experimental session. Diabetic ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Korolkiewicz RP,Tashima K,Fujita A,Kato S,Takeuchi K

    更新日期:2000-02-01 00:00:00

  • Muscarinic M(2) receptors are not primarily involved in the contraction of guinea-pig gallbladder smooth muscle.

    abstract::The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

    更新日期:1999-11-01 00:00:00