Abstract：
:The investigation was aimed at investigating whether the dopaminergic projection arriving at the nucleus septi lateralis (NSL) is involved in the facilitatory effect of vasopressin (AVP) on memory retrieval. The bilateral 6-OHDA lesions to the NSL were made in 20 male Wistar rats before testing the intracerebroventricular (i.c.v.) AVP injection on recall in a passive avoidance situation. Eighteen additional rats served as sham-operated controls. Thirty minutes before surgery rats were pre-treated with an intraperitoneal injection of 25 mg kg-1 of desmethylimipramine, an inhibitor of norepinephrine uptake. Sixteen lesioned and 16 sham-operated rats were included in the study. AVP (1 microgram, i.c.v.) given 15 min before the retention testing significantly improved latencies both in lesioned and in sham-operated rats in comparison with the respective i.c.v. saline-injected animals. However, bilateral lesions to the NSL significantly diminished the facilitatory effect of AVP on recall. The insignificant decrease of spontaneous psychomotor activity in rats lesioned to the NSL was unlikely to interfere with the cognitive effect of AVP. These results suggest that dopaminergic projection to the NSL is involved in the facilitatory effect of AVP on the retrieval process in a passive avoidance situation.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Winnicka MM,Wiśniewski Kdoi
10.1006/phrs.1997.0280subject
Has Abstractpub_date
1998-02-01 00:00:00pages
145-50issue
2eissn
1043-6618issn
1096-1186pii
S1043661897902802journal_volume
37pub_type
杂志文章abstract：:Secretion of matrix metalloproteinases (MMPs) by macrophages and smooth muscle cells (SMC) may impair atherosclerotic cap integrity leading to atherosclerosis complications. Selective estrogen receptor modulators (SERMs) have favourable impact on plasma lipid levels, but their role in the prevention of atherosclerosis...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2007.05.004
更新日期：2007-08-01 00:00:00
abstract：:Though the AMPA receptor has been implicated in several neurodegenerative processes (epilepsy, ischemia, spasticity), its role in cognition is yet to be clarified. The aim of this study was to assess in the rat the effects of the AMPA receptor antagonist NBQX (3.5, 7, 10, 20 and 30 mgkg(-1), i.p.) on learning and memo...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.2001.0898
更新日期：2002-01-01 00:00:00
abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...
journal_title：Pharmacological research
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更新日期：2000-01-01 00:00:00
abstract：:HMG-CoA reductase inhibitors (statins) have been shown to improve cardiovascular (CV) outcomes in the general population as well as in patients with cardiovascular disease (CVD). Statins' beneficial effects have been attributed to both cholesterol-lowering and cholesterol-independent "pleiotropic" properties. By their...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2014.06.011
更新日期：2014-10-01 00:00:00
abstract：:Statins have, at present, the potential to provide a new therapeutic target for various neurological diseases. It is well established that statins reduce cholesterol levels and prevent coronary heart disease. Moreover, evidence suggest that statins have additional properties such as endothelial protection via action o...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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abstract：:Nebivolol, a third generation selective beta(1)-adrenoceptor (beta(1)-AR) antagonist, has been reported to reduce intracellular oxidative stress and to induce the release of nitric oxide (NO) from the endothelium. Nebivolol is also subjected to a complex metabolic process where glucuronidation, aromatic and alicyclic ...
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journal_title：Pharmacological research
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doi：10.1016/j.phrs.2003.09.001
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2019.104403
更新日期：2019-10-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2000-05-01 00:00:00
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更新日期：2018-03-01 00:00:00
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journal_title：Pharmacological research
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doi：10.1016/1043-6618(90)90745-y
更新日期：1990-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2013-08-01 00:00:00
abstract：OBJECTIVES:There is still a need to develop new effective medications for the treatment of ulcerative colitis, particularly for patients who are intolerant or resistant to first line therapies. This article compared the efficacy and safety of etrolizumab and infliximab in moderate to severe ulcerative colitis. METHODS...
journal_title：Pharmacological research
pub_type： 杂志文章,meta分析
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更新日期：2019-01-01 00:00:00
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更新日期：1989-09-01 00:00:00
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更新日期：2015-02-01 00:00:00
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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journal_title：Pharmacological research
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更新日期：2003-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1998.0398
更新日期：1998-12-01 00:00:00
abstract：:It is well known that type 2 diabetes mellitus is frequently associated with vascular dysfunction and an elevated systemic blood pressure, yet the underlying mechanisms are not completely understood. We previously reported that in mesenteric arteries from established type 2 diabetic Otsuka Long-Evans Tokushima fatty (...
journal_title：Pharmacological research
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doi：10.1016/j.phrs.2010.03.003
更新日期：2010-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1998.0484
更新日期：1999-07-01 00:00:00
abstract：:Pepducins are cell-penetrating, membrane-tethered lipopeptides designed to target the intracellular region of a G protein-coupled receptor (GPCR) in order to allosterically modulate the receptor's signaling output. In this proof-of-concept study, we explored the pain-relief potential of a pepducin series derived from ...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2020.104750
更新日期：2020-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2017.07.015
更新日期：2017-10-01 00:00:00
abstract：:The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and ac...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1006/phrs.1997.0269
更新日期：1998-02-01 00:00:00
abstract：BACKGROUND:Many flavonoids have various beneficial actions like anti-inflammatory, anti-carcinogenic properties and many other clinical conditions. Astilbin is one such flavanoid compound having many physiological as well as pharmacological actions. PURPOSE:To summarize the important findings from the research conduct...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2020.104894
更新日期：2020-08-01 00:00:00
abstract：:A decrease in constitutive nitric oxide synthase (cNOS) activity occurred with decreases in hexosamine (an index of mucus synthesis) and adherent mucus (an index of mucus secretion) concentrations in the gastric mucosa of rats with water immersion restraint (WIR) stress. The decreases in gastric mucosal hexosamine and...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1998.0379
更新日期：1998-11-01 00:00:00
abstract：:The insulinotropic action of several new esters of succinic acid was assessed in isolated rat islets incubated in the presence of 7 mM D-glucose. An efficient secretory response was observed with the monobenzyl, monoisopropyl, monoallyl, monopropyl, monoethyl, monobutyl, dibutyl, dipropyl and diallyl esters of succini...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1996.0038
更新日期：1996-04-01 00:00:00
