ASTILBIN: A PROMISING UNEXPLORED COMPOUND WITH MULTIDIMENSIONAL MEDICINAL AND HEALTH BENEFITS.

abstract：:Severely obese patients undergoing bariatric surgery (BS) are at increased risk for venous thromboembolism (VTE). How standard low molecular weight heparin (LMWH) regimen should be adapted to provide both sufficient efficacy and safety in this setting is unclear. We aimed to compare the influence of four body size des...

journal_title：Pharmacological research

authors： Gaborit B,Moulin PA,Bege T,Boullu S,Vincentelli C,Emungania O,Morange PE,Berdah S,Salem JE,Dutour A,Frere C

更新日期：2018-05-01 00:00:00

abstract：:We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

journal_title：Pharmacological research

authors： Campos BG,Ferreira RR,Gomes JC

更新日期：2000-03-01 00:00:00

abstract：:Postnatal bone marrow contains a subtype of unique progenitor cells that have the capacity to differentiate into functional endothelial cells. Hence, these cells have been termed endothelial progenitor cells (EPCs). In general, circulating EPCs were characterized by the expression of CD133, CD34 and the vascular endot...

journal_title：Pharmacological research

authors： Hristov M,Weber C

更新日期：2008-08-01 00:00:00

abstract：:The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...

journal_title：Pharmacological research

authors： Turan NN,Demiryürek AT,Kanzik I

更新日期：2000-05-01 00:00:00

abstract：:The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly att...

journal_title：Pharmacological research

authors： Zalewska-Wińska A,Wiśniewski K

更新日期：2000-09-01 00:00:00

abstract：:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a s...

journal_title：Pharmacological research

authors： Brites GS,Ferreira I,Sebastião AI,Silva A,Carrascal M,Neves BM,Cruz MT

更新日期：2020-12-01 00:00:00

abstract：:The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

journal_title：Pharmacological research

authors： Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

更新日期：1999-11-01 00:00:00

abstract：:Bioequivalence studies are mainly required to demonstrate the interchangeability of multisource pharmaceutical products, usually called generics. A pivotal investigation projected and conducted in compliance with specific guidelines allows a replicative company to register a generic drug via an ANDA (abbreviated new d...

journal_title：Pharmacological research

authors： Marzo A

更新日期：1995-10-01 00:00:00

abstract：:The interaction of mianserin with ethanol in central nervous system (CNS) was investigated. Mianserin was administered at a single dose of 5 or 20 mgkg(-1) i.p. or as daily injections in a dose of 2.5 mgkg(-1) given for 14 days. The influence of mianserin on acute ethanol toxicity (LD(50)), on ED(50) of ethanol in rot...

journal_title：Pharmacological research

authors： Pietrzak B,Kubik-Bogucka E

更新日期：2002-07-01 00:00:00

abstract：:Diarrhea is a common side effect experienced by cancer patients undergoing clinical chemotherapy, such as with 5-fluorouracil (5-FU). However, the precise mechanisms underlying 5-FU-induced diarrhea remain unclear. In the present study, we examined the role of neutrophil in 5-FU-induced diarrhea. Mice were given 5-FU ...

journal_title：Pharmacological research

authors： Sakai H,Sagara A,Matsumoto K,Jo A,Hirosaki A,Takase K,Sugiyama R,Sato K,Ikegami D,Horie S,Matoba M,Narita M

更新日期：2014-09-01 00:00:00

abstract：:When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influen...

journal_title：Pharmacological research

authors： Ferland DJ,Watts SW

更新日期：2015-09-01 00:00:00

abstract：:Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is evaluated on two melanoma cell lines with dissimilar molecular background, B16 and A375. The treatment of both cell lines...

journal_title：Pharmacological research

authors： Krajnović T,Kaluđerović GN,Wessjohann LA,Mijatović S,Maksimović-Ivanić D

更新日期：2016-03-01 00:00:00

abstract：:Fatty-acid amide hydrolase (FAAH) catalyzes the intracellular hydrolysis of the endocannabinoid anandamide and other bioactive lipid amides. In the present study, we conducted a comparative characterization of the effects of the newly identified brain-impermeant FAAH inhibitor, URB937 ([3-(3-carbamoylphenyl)-4-hydroxy...

journal_title：Pharmacological research

authors： Sasso O,Bertorelli R,Bandiera T,Scarpelli R,Colombano G,Armirotti A,Moreno-Sanz G,Reggiani A,Piomelli D

更新日期：2012-05-01 00:00:00

abstract：:The aim of this study was to investigate effect of antiemetics on G6PD and antioxidant enzymes. Antiemetics are currently being used to reduce or prevent nausea and vomiting in patients. This is the first study to show effect of antiemetics on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities....

journal_title：Pharmacological research

authors： Ozmen I,Küfrevioglu OI

更新日期：2004-11-01 00:00:00

abstract：:Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...

journal_title：Pharmacological research

authors： Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

更新日期：2001-03-01 00:00:00

abstract：:The Janus kinase (JAK) family of non-receptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (tyrosine kinase-2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that regulates the adjacent protein kinase domain (JH1). JAK1/2 and TYK2 are ubiquitously expressed whereas JAK3 is...

journal_title：Pharmacological research

authors： Roskoski R Jr

更新日期：2016-09-01 00:00:00

abstract：:The study was undertaken using selected pharmacodynamic parameters to describe the effects of porcine galanin(1-29)-NH2; porcine galanin fragments; galantide; porcine galanin(1-14)-[alpha-aminobutyric acid8]scyliorhinin-I and the analogues of the latter peptides on rat isolated gastric fundus muscle. All tested peptid...

journal_title：Pharmacological research

authors： Korolkiewicz R,Sliwiński W,Rekowski P,Halama-Borowiec A,Mucha P,Szczurowicz A,Korolkiewicz KZ

更新日期：1997-01-01 00:00:00

abstract：:Corticosteroids are shown to have deleterious effects on wound healing for various tissues. Arginine metabolism and nitric oxide (NO) synthesis play an important role in many aspects of inflammation and wound healing. The study was designed to evaluate the relationship of dexamethasone impaired healing of tracheal ana...

journal_title：Pharmacological research

authors： Talas DU,Nayci A,Polat G,Atis S,Comelekoglu U,Bagdatoglu OT,Bagdatoglu C

更新日期：2002-09-01 00:00:00

abstract：:Non-steroidal anti-inflammatory drugs (NSAIDs) are frequently used as analgesics. Although the results of clinical studies indicate considerable disparity in the analgesic efficacy of NSAIDs, the pre-clinical models generally used for the study of nociception do not allow a clear distinction to be made between the ana...

journal_title：Pharmacological research

authors： Bianchi M,Panerai AE

更新日期：2002-02-01 00:00:00

abstract：:To assess the potential role of vasoactive cardiac eicosanoids in the modulation of coronary flow, we measure thromboxane(TX)B2, 6-keto-prostaglandin(PG)F1 alpha, PGE2 and sulphido-peptide leukotrienes (LTC4, D4, E4) in the coronary effluent of isolated perfused rat heart in both baseline and post-ischaemic conditions...

journal_title：Pharmacological research

authors： Giannessi D,Lazzerini G,Sicari R,DeCaterina R

更新日期：1992-12-01 00:00:00

abstract：:We report a first-in-patient study of vamorolone, a first-in-class dissociative steroidal anti-inflammatory drug, in Duchenne muscular dystrophy. This 2-week, open-label Phase IIa multiple ascending dose study (0.25, 0.75, 2.0, and 6.0 mg/kg/day) enrolled 48 boys with Duchenne muscular dystrophy (4 to <7 years), with ...

journal_title：Pharmacological research

authors： Conklin LS,Damsker JM,Hoffman EP,Jusko WJ,Mavroudis PD,Schwartz BD,Mengle-Gaw LJ,Smith EC,Mah JK,Guglieri M,Nevo Y,Kuntz N,McDonald CM,Tulinius M,Ryan MM,Webster R,Castro D,Finkel RS,Smith AL,Morgenroth LP,Arrieta

更新日期：2018-10-01 00:00:00

abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

journal_title：Pharmacological research

authors： Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

更新日期：2000-01-01 00:00:00

abstract：:Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

journal_title：Pharmacological research

authors： Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

更新日期：2020-09-01 00:00:00

abstract：:The endocannabinoid signalling system includes: (1) at least two G-protein-coupled receptors, known as the cannabinoid CB(1) and CB(2) receptors and discovered following studies on the mechanism of action of Delta(9)-tetrahydrocannabinol, the major psychoactive principle of the hemp plant Cannabis sativa; (2) the endo...

journal_title：Pharmacological research

authors： Di Marzo V

更新日期：2009-08-01 00:00:00

abstract：:Purine release and prostaglandin (PG) outflow were simultaneously evaluated from untreated glial primary cultures of rat striatum, at rest and under field electrical stimulation. Purine release was also assayed from sister cultured cells in which a suitable pharmacological treatment with 1 x 10(-6) M dexamethasone or ...

journal_title：Pharmacological research

authors： Caciagli F,Ciccarelli R,Di Iorio P,Tacconelli L,Ballerini P

更新日期：1989-05-01 00:00:00

abstract：:The aim of this review is to underline the redundancy of down-regulation pathways for p53, at the light of the two more important degradative systems: calpains and ubiquitin-dependent pathways. The MDM2 feed-back loop is also illustrated, as well as the phosphorylative/dephosphorylative regulation of the latent and ac...

journal_title：Pharmacological research

authors： Cinelli M,Magnelli L,Chiarugi V

更新日期：1998-02-01 00:00:00

abstract：:The insulinotropic action of the meglitinide analogues KAD-1229, A-4166 and repaglinide was examined in rat pancreatic islets deprived of exogenous nutrient or incubated in the presence of nutrient secretagogues such as D-glucose and the methyl esters of pyruvic acid, succinic acid and glutamic acid. The meglitinide a...

journal_title：Pharmacological research

authors： Bakkali Nadi A,Zhang TM,Malaisse WJ

更新日期：1996-03-01 00:00:00

abstract：:Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

journal_title：Pharmacological research

authors： Eroglu L,Tuna R,Caglayan B

更新日期：1996-02-01 00:00:00

abstract：:The Ras-Raf-MEK-ERK (Map kinase) cellular pathway is a highly conserved eukaryotic signaling module that transduces extracellular signals from growth factors and cytokines into intracellular regulatory events that are involved in cell growth and proliferation or the contrary pathway of cell differentiation. Dysregulat...

journal_title：Pharmacological research

authors： Roskoski R Jr

更新日期：2017-03-01 00:00:00

abstract：:Cancer immunotherapies are dramatically reshaping the clinical management of oncologic patients. For many of these therapies, the guidelines for administration, monitoring, and management of associated toxicities are still being established. This is especially relevant for adoptively transferred, genetically-modified ...

journal_title：Pharmacological research

authors： Ramello MC,Haura EB,Abate-Daga D

更新日期：2018-03-01 00:00:00