Abstract:
:The effects of betel leaf extract (0.10, 0.40, 0.80 and 2.0 g kg-1 day-1 for 15 days) on the alterations in thyroid hormone concentrations. lipid peroxidation (LPO) and on the activities of superoxide dismutase (SOD) and catalase (CAT) were investigated in male Swiss mice. Administration of betel leaf extract exhibited a dual role, depending on the different doses. While the lowest dose decreased thyroxine (T4) and increased serum triiodothyronine (T3) concentrations, reverse effects were observed at two higher doses. Higher doses also increased LPO with a concomitant decrease in SOD and CAT activities. However, with the lowest dose most of these effects were reversed. These findings suggest that betel leaf can be both stimulatory and inhibitory to thyroid function, particularly for T3 generation and lipid peroxidation in male mice, depending on the amount consumed.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Panda S,Kar Adoi
10.1006/phrs.1998.0398subject
Has Abstractpub_date
1998-12-01 00:00:00pages
493-6issue
6eissn
1043-6618issn
1096-1186pii
S1043-6618(98)90398-Xjournal_volume
38pub_type
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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journal_title:Pharmacological research
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