Abstract：
:Serotonin (5-HT) is present in high concentration in enterochromaffin cells throughout the gastrointestinal tract, where it plays a very important role, being involved, e.g., in peristaltic and secretory reflexes in response to chemical or mechanical stimuli of the gut. Intestinal 5-HT is inactivated by metabolic degradation after cellular uptake mediated by the serotonin transporter SERT. This mini-review summarizes some recent data obtained by our group on the importance, regional distribution and cell membrane localization of SERT in the rat intestine. From our results, we conclude that SERT is located both at the apical and basolateral cell membranes of intestinal epithelial cells in the three intestinal regions studied: jejunum, ileum and colon. Moreover, we also conclude that inhibition of SERT causes an increase in transmural transport of 5-HT in these three intestinal segments, probably because it increases the extracellular concentration of 5-HT. Consequently, SERT inhibition will be able to cause an increase in the physiological responses of the tissue to this amine. The repercussions of this phenomenon are discussed.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Martel Fdoi
10.1016/j.phrs.2006.04.005subject
Has Abstractpub_date
2006-08-01 00:00:00pages
73-6issue
2eissn
1043-6618issn
1096-1186pii
S1043-6618(06)00074-0journal_volume
54pub_type
杂志文章,评审abstract：:Augmented vasoconstriction is a hallmark of hypertension and is mediated partly by hyper-stimulation of G protein couple receptors (GPCRs) and downstream signaling components. Although GPCR blockade is a key component of current anti-hypertensive strategies, whether hypertension is better managed by directly targeting...
journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
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更新日期：1997-06-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/1043-6618(90)90739-z
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journal_title：Pharmacological research
pub_type： 杂志文章
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doi：10.1016/j.phrs.2020.104750
更新日期：2020-05-01 00:00:00
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journal_title：Pharmacological research
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更新日期：1997-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2019.03.023
更新日期：2019-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2007.01.012
更新日期：2007-03-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/1043-6618(95)80038-7
更新日期：1995-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2019.104329
更新日期：2019-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/1043-6618(91)90089-g
更新日期：1991-10-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2013.06.009
更新日期：2013-10-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2014.02.001
更新日期：2014-03-01 00:00:00
abstract：:Breast cancer, the most prevalent cancer in women, remains the second in the list of cancer mortality, the majority of these fatalities resulted from estrogen receptor alpha (ERα) positive disease. ERα is well known for its function on breast cancer initiation and development and has become the most successful biomark...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2019.104294
更新日期：2019-08-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2016.11.008
更新日期：2017-01-01 00:00:00
abstract：:The natural resin collected from the trunk wood of Protium heptaphyllum is used in folk medicine to treat inflammatory conditions and to hasten wound repair. In the search of new potential anti-inflammatory agents with gastroprotective property, the present study evaluated its effects in experimental models of gastric...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2003.09.001
更新日期：2004-02-01 00:00:00
abstract：:The suppression of the abnormal systemic immune response constitutes a primary strategy for treatment of rheumatoid arthritis (RA); toward this end, the identification of natural compounds with immunosuppressive activity represents a promising strategy for RA drug discovery. Cinnamtannin D1 (CTD-1), a polyphenolic com...
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pub_type： 杂志文章
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更新日期：2020-01-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2005.01.002
更新日期：2005-08-01 00:00:00
abstract：:It is well known that type 2 diabetes mellitus is frequently associated with vascular dysfunction and an elevated systemic blood pressure, yet the underlying mechanisms are not completely understood. We previously reported that in mesenteric arteries from established type 2 diabetic Otsuka Long-Evans Tokushima fatty (...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2010.03.003
更新日期：2010-09-01 00:00:00
abstract：:The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2003.10.004
更新日期：2004-03-01 00:00:00
abstract：:QiShenYiQi Pills (QSYQ) is a compound Chinese medicine widely used in China for treatment of cardiovascular disease. However, limited data are available regarding the anti-fibrotic role of QSYQ after ischemia/reperfusion (I/R) injury. This study aimed to investigate the effect of post-treatment with QSYQ on myocardial...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2019-08-01 00:00:00
abstract：:Radiotherapy plays a critical role in the treatment of non-small cell lung cancer (NSCLC). However, radioresistance is a major barrier against increasing the efficiency of radiotherapy for NSCLC. To understand the mechanisms underlying NSCLC radioresistance, we previously focused on the potential involvement of PIM1, ...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2013.01.005
更新日期：2013-04-01 00:00:00
abstract：:Perfusion of all mammalian heart muscle except hamster with Ca(2+)-free Tyrode and thereafter reperfusion with normal Tyrode causes irreversible damage, the calcium paradox. Our study aims at deciphering the role of creatine kinase, high energy phosphates and Ca(2+)influx in the genesis of myocardial injury in the rat...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1999.0595
更新日期：2000-03-01 00:00:00
abstract：:The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1999.0628
更新日期：2000-05-01 00:00:00
abstract：:Cosmetics are largely diffused substances topically applied to wash, to perfume or to improve the look, nevertheless the number of reported adverse reactions is very low, probably because of underreporting. This could be due to self-diagnosis and self-medication that is common in the presence of not severe reactions. ...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2005.08.003
更新日期：2006-01-01 00:00:00
abstract：:Anti-hypertensive agents may differently stimulate compensatory neuro-hormonal mechanisms and induce different effects on the cardiovascular remodeling and function. The combination of low doses of the two synergistic drugs may lead to a lesser activation of counter regulatory mechanisms and could provide optimal ther...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2004.10.010
更新日期：2005-04-01 00:00:00
abstract：:Gap junctions (GJ) mediate electrical coupling between cardiac myocytes, allowing the spreading of the electrical wave responsible for synchronized contraction. GJ function can be regulated by modulation of connexon densities on membranes, connexin (Cx) phosphorylation, trafficking and degradation. Recent studies have...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2015.03.015
更新日期：2015-05-01 00:00:00
abstract：:Sodium-glucose transporter 2 (SGLT2) inhibitors, also known as gliflozins, are a new class of orally active drugs used in the management of type 2 diabetes. By inhibiting the SGLT responsible for the reabsorption of glucose from the kidney, their use aims primarily to induce glycosuria and, as a consequence, lower gly...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2016.07.001
更新日期：2017-04-01 00:00:00
abstract：:The altered vascular responses to various vasopressors and relaxants have been well reported in various animal models of hypertension, insulin resistance and diabetes. Though the role of oxidative stress (increased superoxide levels) associated with these altered vascular responses in hyperglycemic/diabetic state is w...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2005.11.002
更新日期：2006-03-01 00:00:00
