Abstract：
:The antinociceptive and motor effects of the hydrophilic alpha 2-adrenoceptor agonist ST-91 were studied after intrathecal administration to male Wistar rats in different heat-pain tests and different test settings. Intrathecal administration of ST-91 caused a dose-dependent increase in hind paw licking latency in the hot-plate test, while in contrast with morphine it had a much lower efficacy in the tail-flick test in freely moving conditions. Sprague-Dawley rats gave similar results to those for Wistar rats in this setting. However, when the tail-flick test was performed under chronic restraint conditions (after a 1-h restraining period), the compound caused a significant antinociception. No signs of motor impairment and no changes in electromyographic activity were detected after ST-91 administration. The results indicate a characteristic analgesic profile for ST-91. In the interpretation of ST-91 data, consideration should be paid both to test model differences and to test conditions.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Horváth G,Dobos I,Liszli P,Klimscha W,Szikszay M,Benedek Gdoi
10.1006/phrs.1997.0188subject
Has Abstractpub_date
1997-06-01 00:00:00pages
561-8issue
6eissn
1043-6618issn
1096-1186pii
S1043-6618(97)90188-2journal_volume
35pub_type
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