Abstract：
:In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological analysis which also included semiquantitative scoring of these features. In addition the serum levels of the immunoreactive prolyl hydroxylase (SIRPH), an enzyme involved in the hydroxylation of the procollagen molecule, were significantly higher (44.2 +/- 16.3 micrograms/ml; P less than 0.005) in this group of animals than in controls (26.1 +/- 8.06). On the contrary, animals treated with CCl4 + metadoxine (200 mg/kg i.p.) had less severe liver fibrosis and normal SIRPH levels (21.5 +/- 14.6). These data suggest that metadoxine may be an effective pharmacological tool for preventing the progression of liver disease in rats exposed to CCl4 to cirrhosis.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Annoni G,Contu L,Tronci MA,Caputo A,Arosio Bdoi
10.1016/s1043-6618(05)80067-2keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
87-93issue
1eissn
1043-6618issn
1096-1186pii
S1043-6618(05)80067-2journal_volume
25pub_type
杂志文章abstract：:Sixteen adult hypertensive patients of both sexes, classified as having 'medium' (total lipid profile 240-300 mg dl(-1)), and 'high' (total lipid profile >300 mg dl(-1)) baseline values, underwent serum lipids, lipoproteins and plasma fibrinolytic parameters evaluations after 3 months of cilnidipine treatment. Patient...
journal_title：Pharmacological research
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更新日期：2003-03-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2019-09-01 00:00:00
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更新日期：2009-10-01 00:00:00
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doi：10.1016/j.phrs.2003.12.019
更新日期：2004-08-01 00:00:00
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更新日期：1994-02-01 00:00:00
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journal_title：Pharmacological research
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更新日期：1989-05-01 00:00:00
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更新日期：2017-03-01 00:00:00
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journal_title：Pharmacological research
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更新日期：1996-02-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2015-09-01 00:00:00
abstract：:QiShenYiQi Pills (QSYQ) is a compound Chinese medicine widely used in China for treatment of cardiovascular disease. However, limited data are available regarding the anti-fibrotic role of QSYQ after ischemia/reperfusion (I/R) injury. This study aimed to investigate the effect of post-treatment with QSYQ on myocardial...
journal_title：Pharmacological research
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更新日期：2019-08-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2010-04-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2017-10-01 00:00:00
abstract：:The pharmacological profile of PF-00885706, a selective 5-HT(4) receptor partial agonist, was investigated. PF-00885706 displayed a high binding affinity for the human 5-HT(4d) receptor with a K(i) of 3.7 nM that translates to functional agonist activity in vitro with EC(50) values of 4.0 nM and 6.6 nM in cell-based a...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2009.03.013
更新日期：2009-10-01 00:00:00
abstract：:Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...
journal_title：Pharmacological research
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更新日期：1999-08-01 00:00:00
