当前位置： SCI文献检索 > PHARMACOLOGICAL RESEARCH期刊下所有文献 > Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways.

Osteopontin plays a key role in vascular smooth muscle cell proliferation via EGFR-mediated activation of AP-1 and C/EBPβ pathways.

Abstract：

:Osteopontin (OPN) is known as an active player in the progression of vascular remodeling diseases, however, the precise role in the proliferation of vascular smooth muscle cells (VSMC) is unclear. Thus, this study investigated the role of OPN in VSMC proliferation induced by 4-hydroxynonenal (HNE), and identified the intracellular signaling pathways involved in 4-HNE-induced OPN production. In VSMC primary cultured from rat thoracic aorta as well as in VSMC in the media of aorta, HNE enhanced OPN expression in concentration-dependent manners. Both the proliferation of cultured VSMC and PCNA positive cells in aortic tissues were also increased by HNE, which were attenuated in OPN-deficient cells and aortic tissues isolated from OPN-deficient mice, indicating a pivotal role of OPN in HNE-induced VSMC proliferation. In the promoter assay, HNE increased OPN promoter activity, which was attenuated when the regions harboring AP-1 and C/EBPβ binding sites were mutated. The increased bindings of AP-1 and C/EBPβ to the OPN promoter were also demonstrated by ChIP analysis. In addition, the increases in both OPN expression and the activities of AP-1 and C/EBPβ by HNE were attenuated by AG1478, an EGFR antagonist. Based on these results, it was suggested that HNE induced OPN expression in VSMC via signaling pathways involving AP-1 and C/EBPβ, leading to increases in VSMC proliferation and subsequent vascular remodeling.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Lee SJ,Baek SE,Jang MA,Kim CD

doi

10.1016/j.phrs.2016.03.041

subject

Has Abstract

pub_date

2016-06-01 00:00:00

pages

1-8

eissn

1043-6618

issn

1096-1186

pii

S1043-6618(16)30054-8

journal_volume

108

pub_type

杂志文章

相关文献

PHARMACOLOGICAL RESEARCH文献大全
  • Extensive characterization of the human DDAH1 transgenic mice.

    abstract：PURPOSE OF THE RESEARCH:Overexpression of the human dimethylarginine dimethylaminohydrolase type 1 (hDDAH1) gene was reported to have beneficial cardiovascular effects in mice. To date, it is unclear whether these effects are related to enhanced metabolic clearance of asymmetric dimethylarginine (ADMA) and l-N(G)-mono-...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2009.08.001

    authors： Schwedhelm E,von Leitner EC,Atzler D,Schmitz C,Jacobi J,Meinertz T,Münzel T,Baldus S,Cooke JP,Böger RH,Maas R,Sydow K

    更新日期：2009-12-01 00:00:00

  • EEG and behavioural effects of polyamines (spermine and spermidine) on rabbits.

    abstract：:The EEG and behavioural changes induced by the administration of polyamines (spermine and spermidine) were studied in rabbit. Spermine and spermidine were administered at different doses (200 and 400 micrograms) into the mesencephalic ventricle (i.c.v.) both as a bolus and in constant perfusion (60 min duration). We a...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/1043-6618(90)90754-2

    authors： Bo P,Giorgetti A,Camana C,Savoldi F

    更新日期：1990-07-01 00:00:00

  • Targeted basic research to highlight the role of estrogen and estrogen receptors in the cardiovascular system.

    abstract：:Epidemiological, clinical and animal studies revealed that sex differences exist in the manifestation and outcome of cardiovascular disease (CVD). The underlying molecular mechanisms implicated in these sex differences are not fully understood. The reasons for sex differences in CVD are definitely multifactorial, but ...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2017.01.019

    authors： Dworatzek E,Mahmoodzadeh S

    更新日期：2017-05-01 00:00:00

  • Cruciferous vegetables and human cancer risk: epidemiologic evidence and mechanistic basis.

    abstract：:Cruciferous vegetables are a rich source of glucosinolates and their hydrolysis products, including indoles and isothiocyanates, and high intake of cruciferous vegetables has been associated with lower risk of lung and colorectal cancer in some epidemiological studies. Glucosinolate hydrolysis products alter the metab...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2007.01.009

    authors： Higdon JV,Delage B,Williams DE,Dashwood RH

    更新日期：2007-03-01 00:00:00

  • A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients.

    abstract：BACKGROUND:Overexpression of heat shock proteins (Hsps) is associated to myocardial protection and it has been suggested that they could be a marker of cardiac preservation in conditions such as extracorporeal circulation. Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/s1043-6618(03)00193-2

    authors： Giannessi D,Caselli C,Vitale RL,Crucean A,Murzi B,Del Ry S,Vanini V,Biagini A

    更新日期：2003-11-01 00:00:00

  • Chelidonine selectively inhibits the growth of gefitinib-resistant non-small cell lung cancer cells through the EGFR-AMPK pathway.

    abstract：:Tyrosine kinase inhibitors (TKIs) have been widely used for the clinical treatment of patients with non-small cell lung cancer (NSCLC) harboring mutations in the EGFR. Unfortunately, due to the secondary mutation in EGFR, eventual drug-resistance is inevitable. Therefore, to overcome the resistance, new agent is urgen...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.104934

    authors： Xie YJ,Gao WN,Wu QB,Yao XJ,Jiang ZB,Wang YW,Wang WJ,Li W,Hussain S,Liu L,Leung EL,Fan XX

    更新日期：2020-09-01 00:00:00

  • Inhibition of cell proliferation, cytotoxicity and induction of apoptosis of 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene in gastrointestinal tumour cell lines and preliminary evaluation of its toxicity in vivo.

    abstract：:Our preliminary data suggested that 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadiene [Viale M, Ottone M, Chiavarina B, Mariggiò MA, Prevosto C, Dell'Erba C, et al. Preliminary evaluation in vitro of the inhibition of cell proliferation, cytotoxicity and induction of apoptosis by 1,4-bis(1-naphthyl)-2,3-dinitro-1,3-butadi...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2005.03.011

    authors： Dell'Erba C,Chiavarina B,Fenoglio C,Petrillo G,Cordazzo C,Boncompagni E,Spinelli D,Ognio E,Aiello C,Mariggiò MA,Viale M

    更新日期：2005-09-01 00:00:00

  • Oxaceprol, an atypical inhibitor of inflammation and joint damage.

    abstract：:Oxaceprol, an established therapeutic agent for osteoarthritis, had no effect on macrophage prostaglandin E2 release in vitro and inhibited carrageenan paw oedema at high doses (18-150 mg/kg p.o.). In the same dose range, oxaceprol was comparable to indomethacin (3 mg/kg p.o.) as an inhibitor of yeast hyperalgaesia an...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.1996.0051

    authors： Ionac M,Parnham MJ,Plauchithiu M,Brune K

    更新日期：1996-06-01 00:00:00

  • Therapeutic implication of vascular endothelial growth factor receptor-1 (VEGFR-1) targeting in cancer cells and tumor microenvironment by competitive and non-competitive inhibitors.

    abstract：:The vascular endothelial growth factor receptor-1 (VEGFR-1) is a tyrosine kinase receptor for VEGF-A, VEGF-B, and placental growth factor (PlGF) ligands that is expressed in endothelial, myelomonocytic and tumor cells. VEGF-B and PlGF exclusively bind to VEGFR-1, whereas VEGF-A also binds to VEGFR-2. At variance with ...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2018.08.023

    authors： Lacal PM,Graziani G

    更新日期：2018-10-01 00:00:00

  • Evaluation of 137Cs activity in plant drugs and in some phytoderivatives from Chernobyl accident up to present (1986-1994).

    abstract：:The accident to the nuclear power plant of Chernobyl (in April 1986) caused a radioactive contamination in large areas of the majority of European countries. During the first transient time the fall-out phenomenon was the most important method of contamination, particularly from 131I whose relative isotopic abundance ...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/s1043-6618(95)80011-5

    authors： Curini M,Rosati O,Borio R,Saetta DM,Cicioni R,Forini N,Rongoni A,Dipilato AC

    更新日期：1995-07-01 00:00:00

  • Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors.

    abstract：:In the field of kinase inhibitors for applications in cancer research, tubulin is emerging as a targeted cellular protein that can significantly contribute to their activities. However, investigation of kinase inhibitors beyond the kinome is an area often neglected. Herein, we describe the results of pharmacological s...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2018.06.023

    authors： Hoque M,Abbassi RH,Froio D,Man J,Johns TG,Stringer BW,Day BW,Pajic M,Kassiou M,Munoz L

    更新日期：2018-08-01 00:00:00

  • Therapeutic potential of triterpenoid saponin anemoside B4 from Pulsatilla chinensis.

    abstract：:Pulsatilla Decoction (Bai-Tou-Weng-Tang) has been used medically in China for thousands of years for the treatment of diseases caused by bacteria. In recent decades, Pulsatilla Decoction is becoming a well-known formula prescription used for the treatment of ulcerative colitis in traditional Chinese medicine. Pulsatil...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2020.105079

    authors： Li YH,Zou M,Han Q,Deng LR,Weinshilboum RM

    更新日期：2020-10-01 00:00:00

  • Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart.

    abstract：:Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.1999.0475

    authors： Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

    更新日期：1999-08-01 00:00:00

  • Activity-based protein profiling of the human failing ischemic heart reveals alterations in hydrolase activities involving the endocannabinoid system.

    abstract：AIM:Acute myocardial infarction and subsequent post-infarction heart failure are among the leading causes of mortality worldwide. The endocannabinoid system has emerged as an important modulator of cardiovascular disease, however the role of endocannabinoid metabolic enzymes in heart failure is still elusive. Herein, w...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2019.104578

    authors： van Esbroeck ACM,Varga ZV,Di X,van Rooden EJ,Tóth VE,Onódi Z,Kuśmierczyk M,Leszek P,Ferdinandy P,Hankemeier T,van der Stelt M,Pacher P

    更新日期：2020-01-01 00:00:00

  • Therapeutics in pediatric diabetes: insulin and non-insulin approaches. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

    abstract：:Treatment of pediatric diabetes can be challenging. Strict glucose control can be accompanied by hypoglycemia and weight gain. Recently, there have been many developments in insulin preparations and delivery methods which make insulin levels more close to a physiologic pattern. Newly developed rapid/long acting analog...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1016/j.phrs.2011.08.011

    authors： Kim J,Kim SM,Nguyen HC,Redondo MJ

    更新日期：2012-01-01 00:00:00

  • Fish as model in pharmacological and biological research.

    abstract：:Fish represent the oldest and most diverse classes of vertebrates, comprising around the 48% of the known member species in the subphylum Vertebrata. There are many scientific fields that use fish as models in research, including respiratory and cardiovascular research, cell culture, ecotoxicology, ageing, pharmacolog...

    journal_title：Pharmacological research

    pub_type： 杂志文章,评审

    doi：10.1006/phrs.2001.0845

    authors： Bolis CL,Piccolella M,Dalla Valle AZ,Rankin JC

    更新日期：2001-10-01 00:00:00

  • Microarray analysis of vanillin-regulated gene expression profile in human hepatocarcinoma cells.

    abstract：:Vanillin is one of the most widely used flavor compounds in food and personal products. It has been reported that vanillin is able to inhibit mutagenesis induced by chemical and physical mutagens, and to suppress the invasion and migration of cancer cells. Herein we used the oligonucleotide microarray approach to stud...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2007.09.009

    authors： Cheng WY,Hsiang CY,Bau DT,Chen JC,Shen WS,Li CC,Lo HY,Wu SL,Chiang SY,Ho TY

    更新日期：2007-12-01 00:00:00

  • The importance of regulating the education and training of Traditional Chinese Medicine practitioners and a potential role for ISO/TC 249.

    abstract：:As Traditional Chinese Medicine (TCM) transcends its cultural boundaries and becomes widely used in many countries around the world, one of the major risks to the growing use of TCM internationally is the damage caused to its reputation and to community safety when TCM practitioners are not adequately trained. Ensurin...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.105217

    authors： Li J,Graham D

    更新日期：2020-11-01 00:00:00

  • Neutrophil recruitment is critical for 5-fluorouracil-induced diarrhea and the decrease in aquaporins in the colon.

    abstract：:Diarrhea is a common side effect experienced by cancer patients undergoing clinical chemotherapy, such as with 5-fluorouracil (5-FU). However, the precise mechanisms underlying 5-FU-induced diarrhea remain unclear. In the present study, we examined the role of neutrophil in 5-FU-induced diarrhea. Mice were given 5-FU ...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2014.05.012

    authors： Sakai H,Sagara A,Matsumoto K,Jo A,Hirosaki A,Takase K,Sugiyama R,Sato K,Ikegami D,Horie S,Matoba M,Narita M

    更新日期：2014-09-01 00:00:00

  • Studies on the glycemic and lipidemic effect of monopril and losartan in normal and diabetic rats.

    abstract：:The effects of the angiotensin-converting enzyme (ACE) inhibitor monopril and the angiotensin II receptor blocker losartan on serum glucose, protein levels and some serum lipid components were compared in normal and diabetic rats receiving oral antidiabetic drugs 'repaglinide or gliclazide'. The two antihypertensive a...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2003.12.019

    authors： el-Batran SA,el-Shenawy SM,Nofal SM,Abdel-Salam OM,Arbid MS

    更新日期：2004-08-01 00:00:00

  • Within-patient variability of hormone and cytokine concentrations in heart failure.

    abstract：:Several studies on disease and treatment effects on neurohormones have been conducted with small numbers of patients, using one blood sample as representative of their states. The aim of this study was to assess the within-patient variability of plasma concentrations of several hormones and cytokines of recent interes...

    journal_title：Pharmacological research

    pub_type： 临床试验,杂志文章

    doi：10.1006/phrs.1998.0288

    authors： Masson S,Latini R,Bevilacqua M,Vago T,Sessa F,Torri M,Anesini A,Salio M,Pasotti E,Agnello D,Santoro L,Catania A,Ghezzi P,Moccetti T,Maggioni AP

    更新日期：1998-03-01 00:00:00

  • Green tea polyphenols produce antidepressant-like effects in adult mice.

    abstract：:Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2011.09.007

    authors： Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L

    更新日期：2012-01-01 00:00:00

  • Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus.

    abstract：:Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2016.11.029

    authors： Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

    更新日期：2017-03-01 00:00:00

  • Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.

    abstract：:Metastatic and primary bone cancers are usually accompanied by severe pain that is difficult to manage. In light of the adverse side effects of opioids, manipulation of the endocannabinoid system may provide an effective alternative for the treatment of cancer pain. The present study determined that a local, periphera...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2011.03.007

    authors： Khasabova IA,Chandiramani A,Harding-Rose C,Simone DA,Seybold VS

    更新日期：2011-07-01 00:00:00

  • Gastroprotective and anti-inflammatory effects of resin from Protium heptaphyllum in mice and rats.

    abstract：:The natural resin collected from the trunk wood of Protium heptaphyllum is used in folk medicine to treat inflammatory conditions and to hasten wound repair. In the search of new potential anti-inflammatory agents with gastroprotective property, the present study evaluated its effects in experimental models of gastric...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2003.09.001

    authors： Oliveira FA,Vieira-Júnior GM,Chaves MH,Almeida FR,Florêncio MG,Lima RC Jr,Silva RM,Santos FA,Rao VS

    更新日期：2004-02-01 00:00:00

  • TRPM8 channel activation triggers relaxation of pudendal artery with increased sensitivity in the hypertensive rats.

    abstract：INTRODUCTION:Erectile dysfunction (ED) is frequently encountered in patients with arterial hypertension and there is a recent functional correlation between the expression of thermoreceptor channels TRPM8 (melastatin 8) and alterations in blood pressure in hypertension. The aim of this study was to investigate the func...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2019.104329

    authors： Silva DF,Wenceslau CF,Mccarthy CG,Szasz T,Ogbi S,Webb RC

    更新日期：2019-09-01 00:00:00

  • Biological characterization of PM226, a chromenoisoxazole, as a selective CB2 receptor agonist with neuroprotective profile.

    abstract：:Cannabinoids have emerged as promising neuroprotective agents due to their capability to activate specific targets, which are involved in the control of neuronal homeostasis and survival. Specifically, those ligands that selectively target and activate the CB2 receptor may be useful for their anti-inflammatory and neu...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2016.03.021

    authors： Gómez-Cañas M,Morales P,García-Toscano L,Navarrete C,Muñoz E,Jagerovic N,Fernández-Ruiz J,García-Arencibia M,Pazos MR

    更新日期：2016-08-01 00:00:00

  • The effects of Kctd12, an auxiliary subunit of GABAB receptor in dentate gyrus on behavioral response to chronic social defeat stress in mice.

    abstract：:Adaptive responses to stress are critical to enhance physical and mental well-being, but excessive or prolonged stress may cause inadaptability and increase the risks of psychiatric disorders, such as depression. GABABR signaling is fundamental to brain function and has been identified in neuropsychiatric disorders. K...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/j.phrs.2020.105355

    authors： Deng SL,Hu ZL,Mao L,Gao B,Yang Q,Wang F,Chen JG

    更新日期：2021-01-01 00:00:00

  • Prolonged effect of the tricyclic antidepressant, mianserin on the serotonin and histamine content of young rats' white blood cells and mast cells. A case of late-imprinting.

    abstract：:Perinatal encounter of a hormone and its developing target receptor sets the receptor-hormone-signal transduction complex for life (hormonal imprinting). In this critical period excess of the appropriate hormone or foreign molecules able to bind the receptor can cause faulty imprinting with life-long consequences. At ...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1016/s1043-6618(03)00217-2

    authors： Csaba G,Kovács P,Pállinger E

    更新日期：2003-11-01 00:00:00

  • Losartan influences behavioural effects of angiotensin II in rats.

    abstract：:The role of the angiotensin AT1 receptors in certain behavioural effects of angiotensin II (Ang II), using their selective antagonist losartan (DuP 753), was assessed. Ang II, given intracerebroventricularly (ICV) at the dose of 1 nmole, significantly improved object recognition, learning of conditioned avoidance resp...

    journal_title：Pharmacological research

    pub_type： 杂志文章

    doi：10.1006/phrs.1996.0073

    authors： Kułakowska A,Karwowska W,Wiśniewski K,Braszko JJ

    更新日期：1996-09-01 00:00:00