Prolonged effect of the tricyclic antidepressant, mianserin on the serotonin and histamine content of young rats' white blood cells and mast cells. A case of late-imprinting.

abstract：:The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

journal_title：Pharmacological research

authors： Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

更新日期：1991-10-01 00:00:00

abstract：:By the use of combined radioreceptor binding and autoradiographic techniques we attempted to analyse the biochemical characteristics and the anatomical localization of GABA-B receptors in sections of rat circle of Willis and pialarachnoid arteries. 3H-GABA in the presence of 40 microM isoguvacine and 2.5 mM CaCl2 was ...

journal_title：Pharmacological research

authors： Napoleone P,Ferrante F,Amenta F

更新日期：1990-05-01 00:00:00

abstract：:The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

journal_title：Pharmacological research

authors： Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

更新日期：2000-01-01 00:00:00

abstract：:Antidepressants, especially tricyclic agents (TCAs), are increasingly used in geriatric patients since depression is a common mood disorder in the elderly and the size of elderly population is increasing. Notwithstanding the importance of kinetics to better use of drugs, its study in the elderly (regarding TCAs) is no...

journal_title：Pharmacological research

authors： Furlanut M,Benetello P

更新日期：1990-01-01 00:00:00

abstract：:Annexin A1 is a multifunctional protein characterised by its actions in modulating the innate and adaptive immune response. Accumulating evidence of altered annexin A1 expression in many human tumours raises interest in its functional role in cancer biology. In breast cancer, altered annexin A1 expression levels sugge...

journal_title：Pharmacological research

authors： Tu Y,Johnstone CN,Stewart AG

更新日期：2017-05-01 00:00:00

abstract：:Myocardial infarction (MI) is a major cause of morbidity and mortality in western countries and the formation of intracoronary thrombi is recognized as a critical determinant of this ischaemic event. Since streptokinase and urokinase cause in vitro lysis of clots, it was though that these drugs were also effective in ...

journal_title：Pharmacological research

authors： Di Minno G,Margaglione M,Cerbone AM,Papa R,Mattei A

更新日期：1989-03-01 00:00:00

abstract：:Central nervous system (CNS) drug development faces significant difficulties that translate into high rates of failure and lack of innovation. The pathophysiology of neurological and psychiatric disorders often results in the breakdown of blood-CNS barriers, disturbing the CNS microenvironment and worsening disease pr...

journal_title：Pharmacological research

authors： Bicker J,Alves G,Fonseca C,Falcão A,Fortuna A

更新日期：2020-12-01 00:00:00

abstract：:Some antihistamines (mainly terfenadine and astemizole) have been demonstrated to cause QT interval prolongation and, in some cases, torsade-de-pointes. We investigated the cardiac electrophysiological effects of brompheniramine, a conventional antihistamine. Brompheniramine was reported to prolong QT interval in isol...

journal_title：Pharmacological research

authors： Shin WH,Kim KS,Kim EJ

更新日期：2006-12-01 00:00:00

abstract：:(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg-1, 30 min before the test, significantly decreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg-1) diminished the protective activity of diphenylhydantoin, phenobarbi...

journal_title：Pharmacological research

authors： Borowicz KK,Kleinrok Z,Czuczwar SJ

更新日期：1999-12-01 00:00:00

abstract：:The effect of different L-histidine concentrations on human mammary tumour cell (CG5) proliferation was studied to test the hypothesis of a role of histidine in modulating sex steroid-regulated cell proliferation. Cell growth was only possible in the 10(-5) M and 10(-2) M range, while its inhibition by medroxyprogeste...

journal_title：Pharmacological research

authors： Ghezzo F,Racca S,Conti G,Berta GN,D'Avolio A,Abbadessa G,Gambino G,Di Carlo F

更新日期：1997-02-01 00:00:00

abstract：:Beta-endorphin/beta-lipotropin immunoreactivity (BE/BLPH-IR) content was evaluated in the CSF of patients suffering by deafferentation pain syndromes. BE/BLPH-IR CSF concentrations of these patients were compared with those obtained in a group of patients affected by low back pain and in a control group without pain p...

journal_title：Pharmacological research

authors： Salar G,Alessio L,Govoni S,Battaini F,Iob I,Goss I,Trabucchi M

更新日期：1991-02-01 00:00:00

abstract：:Apoptosis of tissues may contribute to ischaemia-reperfusion injury. The aim of the present study was to determine whether administration of a colloid solution would prevent apoptosis after liver ischaemia-reperfusion. New Zealand rabbits, weighing 1.5-2 kg, were randomized to receive either 4% SG (20 ml kg (-1)h(-1) ...

journal_title：Pharmacological research

authors： Altunkan A,Aydin O,Ozer Z,Colak T,Bilgin E,Oral U

更新日期：2002-06-01 00:00:00

abstract：:Possible interaction between adenosine and L type Ca2+ channel in the locomotor activity of rats was investigated. R-PIA (0.05 mg kg-1), an adenosine analogue, and caffeine (20 mg kg-1), an adenosine receptor antagonist, significantly decreased and increased locomotor activity, respectively. Ca2+ channel blocker nifed...

journal_title：Pharmacological research

authors： Eroglu L,Tuna R,Caglayan B

更新日期：1996-02-01 00:00:00

abstract：:Radiotherapy plays a critical role in the treatment of non-small cell lung cancer (NSCLC). However, radioresistance is a major barrier against increasing the efficiency of radiotherapy for NSCLC. To understand the mechanisms underlying NSCLC radioresistance, we previously focused on the potential involvement of PIM1, ...

journal_title：Pharmacological research

authors： Kim W,Youn H,Kwon T,Kang J,Kim E,Son B,Yang HJ,Jung Y,Youn B

更新日期：2013-04-01 00:00:00

abstract：:The lack of availability of appropriate medicines for children is an extensive and well known problem. As a consequence off label or unlicensed administration of medicinal products in every day paediatric practice is frequent. A variety of obstacles hinder the development of paediatric indications for drugs primarily ...

journal_title：Pharmacological research

authors： Rocchi F,Tomasi P

更新日期：2011-09-01 00:00:00

abstract：:Antifertility activity of a triterpenoid glycoside, DSS, isolated from the root of Dalbergia saxatilis was investigated in female Wistar rats of breeding age. When administered by gastric intubation at a dose rate of 200 mg kg(-1)body weight at the premating period, conception was inhibited in 71.4% of the treated ani...

journal_title：Pharmacological research

authors： Uchendu CN,Kamalu TN,Asuzu IU

更新日期：2000-05-01 00:00:00

abstract：:The purpose of the present work was to study the change in morphine metabolic ratio in obese subjects before and after Roux-en-Y Gastric Bypass (RYGB) and to identify clinical and/or biological factors associated with this change. The pharmacokinetics (PK) of oral morphine (30mg), morphine-3-glucuronide (M3G) and morp...

journal_title：Pharmacological research

authors： Lloret-Linares C,Luo H,Rouquette A,Labat L,Poitou C,Tordjman J,Bouillot JL,Mouly S,Scherrmann JM,Bergmann JF,Declèves X

更新日期：2017-04-01 00:00:00

abstract：:Carbon-based nanomaterials have unique physicochemical properties relevant to the diagnosis and treatment of various diseases. There have been many reports indicating that carbon nanomaterials (CNMs) can interact and perturb biomolecules such as proteins and amyloid structures. This review is an attempt to reflect the...

journal_title：Pharmacological research

authors： Mohajeri M,Behnam B,Barreto GE,Sahebkar A

更新日期：2019-05-01 00:00:00

abstract：:The mechanisms involved in enhanced cough induced by central and inhaled NGF in guinea pigs were investigated. Cough and airway function were assessed by plethysmography following inhaled or intracerebroventricular (i.c.v.) NGF treatment. Expression of TrkA and/or TRPV1 was determined in bronchi and/or brainstem by re...

journal_title：Pharmacological research

authors： El-Hashim AZ,Jaffal SM,Al-Rashidi FT,Luqmani YA,Akhtar S

更新日期：2013-08-01 00:00:00

abstract：:In addiction, an individual's ability to inhibit drug seeking and drug taking is thought to reflect a pathological strengthening of drug-seeking behaviors or impairments in the capacity to control maladaptive behavior. These processes are not mutually exclusive and reflect drug-induced modifications within prefrontal ...

journal_title：Pharmacological research

authors： Hearing M

更新日期：2019-01-01 00:00:00

abstract：:Exogenously administered fructose-1,6-diphosphate (FDP) has been studied for its ability to protect tissue during hypoxia or ischemia. Recently, a clear effect of FDP on the central nervous system has raised the question whether FDP can get into the brain. FDP levels were measured in blood, brain, liver, kidney, muscl...

journal_title：Pharmacological research

authors： Xu K,Stringer JL

更新日期：2008-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs that regulate post-transcriptional gene expression by targeting specific mRNAs for degradation or translation repression. Changes in miRNAs expression profiles have been reported in several neurodegenerative disorders such as Alzheimer's disease (AD) and related tauopathies...

journal_title：Pharmacological research

authors： Bazrgar M,Khodabakhsh P,Mohagheghi F,Prudencio M,Ahmadiani A

更新日期：2020-05-01 00:00:00

abstract：:Using cultured human keratinocytes, the present study investigates the role of nitric oxide (NO) in the mediation of the antiproliferative effects of ultraviolet light A (UVA). UVA treatment of cells (3-21 J cm (-2)) caused a time- and dose-dependent increase in nitrite formation in a micromolar range. This effect was...

journal_title：Pharmacological research

authors： Podhaisky HP,Klapperstück T,Riemschneider S,Wohlrab W

更新日期：2002-03-01 00:00:00

abstract：:In the present study the effect of ketamine, a dissociative anaesthetic, on the GABA- and on the specific GABAA-agonist muscimol-induced responses of the isolated guinea pig ileum was investigated. GABA as well as muscimol produce a concentration-dependent contractile effect on the duodenum, jejunum and ileum. The sen...

journal_title：Pharmacological research

authors： Kounenis G,Koutsoviti-Papadopoulou M,Elezoglou V

更新日期：1995-06-01 00:00:00

abstract：:Targeting on the IKKβ to discover anti-inflammatory drugs has been launched for ten years, due to its predominant role in canonical NF-κB signaling. In the current study, we identified a novel IKKβ inhibitor, ellipticine (ELL), an alkaloid isolated from Ochrosia elliptica and Rauvolfia sandwicensis. We found that ELL ...

journal_title：Pharmacological research

authors： Chen Q,Liu J,Zhuang Y,Bai LP,Yuan Q,Zheng S,Liao K,Khan MA,Wu Q,Luo C,Liu L,Wang H,Li T

更新日期：2019-11-01 00:00:00

abstract：:Mitochondria are best known for their role in ATP generation. However, studies over the past two decades have shown that mitochondria do much more than that. Mitochondria regulate both necrotic and apoptotic cell death pathways, they store and therefore coordinate cellular Ca2+ signaling, they generate and metabolize ...

journal_title：Pharmacological research

authors： Joshi AU,Mochly-Rosen D

更新日期：2018-12-01 00:00:00

abstract：:Osteopontin (OPN) is known as an active player in the progression of vascular remodeling diseases, however, the precise role in the proliferation of vascular smooth muscle cells (VSMC) is unclear. Thus, this study investigated the role of OPN in VSMC proliferation induced by 4-hydroxynonenal (HNE), and identified the ...

journal_title：Pharmacological research

authors： Lee SJ,Baek SE,Jang MA,Kim CD

更新日期：2016-06-01 00:00:00

abstract：:Most solid tumor cells adapt to their heterogeneous microenvironment by depending largely on aerobic glycolysis for energy production, a phenomenon called the Warburg effect, which is a hallmark of cancer. The altered energy metabolism not only provides cancer cell with ATP for cellular energy, but also generate essen...

journal_title：Pharmacological research

authors： Abdel-Wahab AF,Mahmoud W,Al-Harizy RM

更新日期：2019-12-01 00:00:00

abstract：:Recent studies clearly show that there is a relationship between endotoxemia and impaired vascular responsiveness. The aim of this study was to investigate whether treatment with the new potent PARP inhibitor PJ34 could prevent the vascular hyporesponsiveness induced by lipopolysaccharide (LPS). Endotoxemia was induce...

journal_title：Pharmacological research

authors： Tasatargil A,Dalaklioglu S,Sadan G

更新日期：2005-06-01 00:00:00

abstract：:The formation of reactive oxygen species (ROS) appears to play a significant role in many pathological states including cystic fibrosis and asthma. Although stimulated inflammatory cells represent a major source of oxygen metabolites and these cells are able to generate the potent oxidant hypochlorous acid (HOCl) effe...

journal_title：Pharmacological research

authors： Turan NN,Demiryürek AT,Kanzik I

更新日期：2000-05-01 00:00:00