Evidence for a role of nitric oxide in the mediation of antiproliferative UVA effects in keratinocytes.

Abstract:

:Using cultured human keratinocytes, the present study investigates the role of nitric oxide (NO) in the mediation of the antiproliferative effects of ultraviolet light A (UVA). UVA treatment of cells (3-21 J cm (-2)) caused a time- and dose-dependent increase in nitrite formation in a micromolar range. This effect was accompanied by a decrease in DNA synthesis by 53.5%. Moreover, UVA treatment slightly reduced cell viability by 23.8%. Preincubation of keratinocytes with the NO scavenger 4,4,5,5-tetramethyl-imidazoline-1-oxyl-3-oxide (PTIO, 10-100 microM) or the NO synthase inhibitor N(G)-monomethyl-l-arginine (l-NMMA, 30-300 microM) significantly diminished the UVA-induced increase in nitrite. PTIO as well as l-NMMA partially protected keratinocytes from UVA-induced antiproliferative effects and increased DNA synthesis by 67 or 49% of the control. The co-application of UVA irradiation (10 J cm (-2)) and the essential cofactor of NO synthases tetrahydrobiopetrin (BH4, 500 microM) led to an overadditive increase in the release of nitrite as well as to a decrease in DNA synthesis. These results imply that NO is involved in the antiproliferative UVA effects in keratinocytes.

journal_name

Pharmacol Res

journal_title

Pharmacological research

authors

Podhaisky HP,Klapperstück T,Riemschneider S,Wohlrab W

doi

10.1006/phrs.2001.0939

keywords:

subject

Has Abstract

pub_date

2002-03-01 00:00:00

pages

229-33

issue

3

eissn

1043-6618

issn

1096-1186

pii

S1043661801909399

journal_volume

45

pub_type

杂志文章
  • Age, sex, and specific gene mutations affect the effects of immune checkpoint inhibitors in colorectal cancer.

    abstract::The effect of age and sex on the predictive value of colorectal cancer (CRC) patients treated with immune checkpoint inhibitors (ICIs) has been controversial, and the effect of specific gene mutations on the predictive value of CRC patients treated with ICIs remains to be explored. Our study analyzed the influence of ...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2020.105028

    authors: Lin A,Zhang H,Hu X,Chen X,Wu G,Luo P,Zhang J

    更新日期:2020-09-01 00:00:00

  • Tumor-derived extracellular vesicles: Regulators of tumor microenvironment and the enlightenment in tumor therapy.

    abstract::In recent decades, extracellular vesicles (EVs) have been proven to establish an important bridge of communication between cells or cells and their microenvironment. It is well known that EVs play crucial roles in many human diseases, especially in tumors. Tumor-derived EVs (TEVs) are not only involved in epithelial-m...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2020.105041

    authors: Chen J,Fei X,Wang J,Cai Z

    更新日期:2020-09-01 00:00:00

  • Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus.

    abstract::Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2016.11.029

    authors: Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

    更新日期:2017-03-01 00:00:00

  • N-acetyl penicillamine a protector of Plasmodium berghei induced stress organ injury in mice.

    abstract::N-acetyl penicillamine (NAP), a derivative of penicillamine and copper chelator has been employed as a potential protector of host stress organ injury during Plasmodium berghei infection in mice. Intramuscular injection of NAP (60 mg kg-1 body wt for 10 days) to P. berghei mice was able to restrict the hepato- and spl...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1006/phrs.1997.0233

    authors: Srivastava P,Arif AJ,Singh C,Pandey VC

    更新日期:1997-10-01 00:00:00

  • MicroRNAs in chronic airway diseases: Clinical correlation and translational applications.

    abstract::MicroRNAs (miRNAs) are short single-stranded RNAs that have pivotal roles in disease pathophysiology through transcriptional and translational modulation of important genes. It has been implicated in the development of many diseases, such as stroke, cardiovascular conditions, cancers and inflammatory airway diseases. ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2020.105045

    authors: Tan BWQ,Sim WL,Cheong JK,Kuan WS,Tran T,Lim HF

    更新日期:2020-10-01 00:00:00

  • β3 adrenergic receptor activation relaxes human corpus cavernosum and penile artery through a hydrogen sulfide/cGMP-dependent mechanism.

    abstract::Erectile function is a widely accepted indicator of systemic endothelial activity since from a clinical standpoint erectile dysfunction (ED) often precedes cardiovascular events. Recently it has been described a potential role for β3 adrenoceptor in cardiovascular diseases emphasizing a possible development of new dru...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2017.07.025

    authors: Mitidieri E,Tramontano T,Gurgone D,Imbimbo C,Mirone V,Fusco F,Cirino G,d'Emmanuele di Villa Bianca R,Sorrentino R

    更新日期:2017-10-01 00:00:00

  • A TCM formula comprising Sophorae Flos and Lonicerae Japonicae Flos alters compositions of immune cells and molecules of the STAT3 pathway in melanoma microenvironment.

    abstract::A traditional Chinese medicine (TCM) formula (SL) comprising Sophorae Flos and Lonicerae Japonicae Flos was used for treating melanoma in ancient China. We have previously shown that an ethanolic extract of SL (SLE) possesses anti-melanoma effects and suppresses STAT3 signaling in vitro and in vivo. STAT3 has been lin...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2019.02.020

    authors: Liu YX,Bai JX,Li T,Fu XQ,Guo H,Zhu PL,Chan YC,Chou JY,Yin CL,Li JK,Wang YP,Chen YJ,Yu ZL

    更新日期:2019-04-01 00:00:00

  • Inhibition of the NANC relaxation of the guinea-pig proximal colon longitudinal muscle by the purinoceptor antagonist PPADS, inhibition of nitric oxide synthase, but not by a PACAP/VIP antagonist.

    abstract::The effects of the P(2)-purinoceptor antagonist pyridoxal-phosphate-6-azophenyl- 2('),4(')- disulphonic acid (PPADS), the nitric oxide (NO) synthase inhibitor N(G)-nitro- l -arginine (l -NOARG), the K(+)-channel blocker apamin, the pituitary adenylate cyclase activating peptide (PACAP) antagonist PACAP(6-38) and the s...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1006/phrs.2000.0742

    authors: Rózsai B,Lázár Z,Benkó R,Barthó L

    更新日期:2001-01-01 00:00:00

  • The effect of manganese chloride on gentamicin-induced nephrotoxicity in rats.

    abstract::The aim of this study was to investigate the effects of manganese chloride on gentamicin-induced nephrotoxicity in rats. Thirty-six adult Wistar Albino rats were divided into six equal groups. They were injected with gentamicin sulfate (100 mg kg(-1) per day i.p.) and manganese chloride (2 or 20 mg kg(-1) per day i.p....

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/s1043-6618(03)00227-5

    authors: Ateşşahin A,Karahan I,Yilmaz S,Ceribaşi AO,Princci I

    更新日期:2003-12-01 00:00:00

  • Caveolin1/protein arginine methyltransferase1/sirtuin1 axis as a potential target against endothelial dysfunction.

    abstract::Endothelial dysfunction (ED), an established response to cardiovascular risk factors, is characterized by increased levels of soluble molecules secreted by endothelial cells (EC). Evidence suggest that ED is an independent predictor of cardiac events and that it is associated with a deficiency in production or bioavai...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2017.01.022

    authors: Charles S,Raj V,Arokiaraj J,Mala K

    更新日期:2017-05-01 00:00:00

  • Haemodynamic effects of nisoldipine by oral route.

    abstract::The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/1043-6618(91)90089-g

    authors: Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

    更新日期:1991-10-01 00:00:00

  • Ameliorative potential of rosiglitazone in tibial and sural nerve transection-induced painful neuropathy in rats.

    abstract::The present study was designed to investigate the ameliorative potential of rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) agonist, in tibial and sural nerve transection-induced neuropathic pain in rats. The pinprick, cold immersion, hot plate and hot immersion tests were performed to a...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2009.02.001

    authors: Jain V,Jaggi AS,Singh N

    更新日期:2009-06-01 00:00:00

  • Anti-arrhythmic drug therapy in implantable cardioverter-defibrillator recipients.

    abstract::Implantable cardioverter-defibrillators (ICDs) have revolutionized the primary and secondary prevention of patients with ventricular arrhythmias. However, the adverse effects of appropriate or inappropriate shocks may require the adjunctive use of anti-arrhythmic drugs (AADs). Beta blockers are the cornerstone of phar...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2019.03.020

    authors: AlTurki A,Proietti R,Russo V,Dhanjal T,Banerjee P,Essebag V

    更新日期:2019-05-01 00:00:00

  • Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries.

    abstract:OBJECTIVE:The vasorelaxant effect of 2-arachidonoylglycerol (2-AG) has been well characterised in animals. 2-AG is present in human vascular cells and is up-regulated in cardiovascular pathophysiology. However, the acute vascular actions of 2-AG have not been explored in humans. APPROACH:Mesenteric arteries were obtai...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2014.02.001

    authors: Stanley CP,O'Sullivan SE

    更新日期:2014-03-01 00:00:00

  • Pyridoxol L,2-pyrrolidon-5 carboxylate prevents active fibroplasia in CCl4-treated rats.

    abstract::In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/s1043-6618(05)80067-2

    authors: Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

    更新日期:1992-01-01 00:00:00

  • Effects of antiemetic drugs on glucose 6-phosphate dehydrogenase and some antioxidant enzymes.

    abstract::The aim of this study was to investigate effect of antiemetics on G6PD and antioxidant enzymes. Antiemetics are currently being used to reduce or prevent nausea and vomiting in patients. This is the first study to show effect of antiemetics on glucose-6-phosphate dehydrogenase (G6PD) and antioxidant enzyme activities....

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2004.05.007

    authors: Ozmen I,Küfrevioglu OI

    更新日期:2004-11-01 00:00:00

  • Green tea polyphenols produce antidepressant-like effects in adult mice.

    abstract::Recent studies have shown that a higher consumption of green tea leads to a lower prevalence of depressive symptoms in elderly individuals. However, no studies have explored the antidepressant-like effect of green tea in preclinical models of depression. The aim of this study was to investigate the antidepressant-like...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2011.09.007

    authors: Zhu WL,Shi HS,Wei YM,Wang SJ,Sun CY,Ding ZB,Lu L

    更新日期:2012-01-01 00:00:00

  • Within-patient variability of hormone and cytokine concentrations in heart failure.

    abstract::Several studies on disease and treatment effects on neurohormones have been conducted with small numbers of patients, using one blood sample as representative of their states. The aim of this study was to assess the within-patient variability of plasma concentrations of several hormones and cytokines of recent interes...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章

    doi:10.1006/phrs.1998.0288

    authors: Masson S,Latini R,Bevilacqua M,Vago T,Sessa F,Torri M,Anesini A,Salio M,Pasotti E,Agnello D,Santoro L,Catania A,Ghezzi P,Moccetti T,Maggioni AP

    更新日期:1998-03-01 00:00:00

  • Effect of sodium-glucose co-transporter 2 inhibitors on lipid profile: A systematic review and meta-analysis of 48 randomized controlled trials.

    abstract::Previous studies have suggested additional beneficial effects of sodium-glucose co-transporter-2 (SGLT2) inhibitors including the lipid-lowering effect; however, results on lipid profile are controversial. Thus, this meta-analysis aimed to determine the effect of SGLT2 inhibitors treatment on lipid levels in patients ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2020.105068

    authors: Sánchez-García A,Simental-Mendía M,Millán-Alanís JM,Simental-Mendía LE

    更新日期:2020-10-01 00:00:00

  • Protection from apoptotic cell death by cilostazol, phosphodiesterase type III inhibitor, via cAMP-dependent protein kinase activation.

    abstract::This study aimed to elucidate whether the effect of cilostazol to suppress apoptotic cell death is directly coupled to cAMP-dependent protein kinase activation in human umbilical vein endothelial cells (HUVECs). After exposure of HUVECs to LPS (1 microgml(-1)) for 18 h, the endothelial cells irregularly aggregated wit...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2006.05.006

    authors: Kim MJ,Lee JH,Park SY,Hong KW,Kim CD,Kim KY,Lee WS

    更新日期:2006-10-01 00:00:00

  • Prefrontal-accumbens opioid plasticity: Implications for relapse and dependence.

    abstract::In addiction, an individual's ability to inhibit drug seeking and drug taking is thought to reflect a pathological strengthening of drug-seeking behaviors or impairments in the capacity to control maladaptive behavior. These processes are not mutually exclusive and reflect drug-induced modifications within prefrontal ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2018.11.012

    authors: Hearing M

    更新日期:2019-01-01 00:00:00

  • Endocannabinoids and cardiac contractile function: pathophysiological implications.

    abstract::Endocannabinoids are part of a bioactive lipid signaling system, not only in the central nervous system but also in various peripheral organs. Accumulating evidence implicates dysregulation of the endocannabinoid system (ECS) in the pathogenesis of various cardiovascular diseases, including hypertension, atheroscleros...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2009.04.003

    authors: Bátkai S,Pacher P

    更新日期:2009-08-01 00:00:00

  • Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases.

    abstract::The Janus kinase (JAK) family of non-receptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (tyrosine kinase-2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that regulates the adjacent protein kinase domain (JH1). JAK1/2 and TYK2 are ubiquitously expressed whereas JAK3 is...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2016.07.038

    authors: Roskoski R Jr

    更新日期:2016-09-01 00:00:00

  • Pharmacological modulation in mesial temporal lobe epilepsy: Current status and future perspectives.

    abstract::Mesial temporal lobe epilepsy (MTLE) is frequently associated with hippocampal sclerosis (Hs), possibly caused by a primary brain injury that occurs a long time before the appearance of neurological symptoms. MTLE-Hs is, however, a heterogeneous condition that evolves with time, involving both environmental and geneti...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审

    doi:10.1016/j.phrs.2016.09.019

    authors: Gambardella A,Labate A,Cifelli P,Ruffolo G,Mumoli L,Aronica E,Palma E

    更新日期:2016-11-01 00:00:00

  • Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart.

    abstract::Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1006/phrs.1999.0475

    authors: Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

    更新日期:1999-08-01 00:00:00

  • Gene silencing of receptor-interacting protein 2 protects against cigarette smoke-induced acute lung injury.

    abstract:BACKGROUND AND PURPOSE:Chronic obstructive pulmonary disease (COPD) is characterized by progressive alveolar damage and generally irreversible airflow limitation. Nuclear factor-κB (NF-κB) plays a critical role in COPD pathogenesis. Receptor-interacting protein 2 (Rip2), a 60 kDa adaptor protein, is a positive regulato...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2018.10.016

    authors: Dong J,Liao W,Tan LH,Yong A,Peh WY,Wong WSF

    更新日期:2019-01-01 00:00:00

  • A possible cardioprotective effect of heat shock proteins during cardiac surgery in pediatric patients.

    abstract:BACKGROUND:Overexpression of heat shock proteins (Hsps) is associated to myocardial protection and it has been suggested that they could be a marker of cardiac preservation in conditions such as extracorporeal circulation. Aim of this study was to evaluate if cardioplegic arrest can modify the expression of Hsps in the...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/s1043-6618(03)00193-2

    authors: Giannessi D,Caselli C,Vitale RL,Crucean A,Murzi B,Del Ry S,Vanini V,Biagini A

    更新日期:2003-11-01 00:00:00

  • The soy phytoestrogens genistein and daidzein as neuroprotective agents against anoxia-glucopenia and reperfusion damage in rat urinary bladder.

    abstract::Some bladder disorders, such as obstructive bladder and hyperactivity, may be caused partly by ischemia/reperfusion injury (I/R). The neuroprotective effects of estrogens were demonstrated in in vitro studies and a great interest in soy isoflavones (genistein and daidzein) as alternative to the synthetic estrogen rece...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2012.06.007

    authors: Valeri A,Fiorenzani P,Rossi R,Aloisi AM,Valoti M,Pessina F

    更新日期:2012-10-01 00:00:00

  • Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.

    abstract::Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions. In this work, we ...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1016/j.phrs.2020.105105

    authors: Gómez-Escribano AP,Bono-Yagüe J,García-Gimeno MA,Sequedo MD,Hervás D,Fornés-Ferrer V,Torres-Sánchez SC,Millán JM,Sanz P,Vázquez-Manrique RP

    更新日期:2020-11-01 00:00:00

  • Muscarinic M(2) receptors are not primarily involved in the contraction of guinea-pig gallbladder smooth muscle.

    abstract::The presence of M(1)-M(4) receptors in guinea-pig gallbladder smooth muscle cells has been reported recently. The majority of these receptors are said to be of M(2) subtype. However, there are controversial reports about the functional muscarinic receptors that mediate contraction in this tissue. Similar to gallbladde...

    journal_title:Pharmacological research

    pub_type: 杂志文章

    doi:10.1006/phrs.1999.0536

    authors: Akici A,Karaalp A,Skender E,El-Fakahany EE,Oktay S

    更新日期:1999-11-01 00:00:00