Carbon nanomaterials and amyloid-beta interactions: potentials for the detection and treatment of Alzheimer's disease?


:Carbon-based nanomaterials have unique physicochemical properties relevant to the diagnosis and treatment of various diseases. There have been many reports indicating that carbon nanomaterials (CNMs) can interact and perturb biomolecules such as proteins and amyloid structures. This review is an attempt to reflect the role of CNMs in the treatment and detection of Alzheimer's disease (AD). The potential of CNMs in the field of neuroscience has also been reviewed. The exposure to CNMs ends up with effective radical and peptide scavenging structures, which, in turn, inhibit further formation and progression of amyloid fibrils. However, the effect of CNMs on initial nucleation and lag phase in this process may promote fibrillation. We have discussed the controversy that whether CNMs promote or inhibit the formation of amyloid beta (Aβ) fibrils to help preventing their toxicity or enhancing their therapeutic effects.


Pharmacol Res


Pharmacological research


Mohajeri M,Behnam B,Barreto GE,Sahebkar A




Has Abstract


2019-05-01 00:00:00












  • QiShenYiQi Pills® ameliorates ischemia/reperfusion-induced myocardial fibrosis involving RP S19-mediated TGFβ1/Smads signaling pathway.

    abstract::QiShenYiQi Pills (QSYQ) is a compound Chinese medicine widely used in China for treatment of cardiovascular disease. However, limited data are available regarding the anti-fibrotic role of QSYQ after ischemia/reperfusion (I/R) injury. This study aimed to investigate the effect of post-treatment with QSYQ on myocardial...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zheng QN,Wei XH,Pan CS,Li Q,Liu YY,Fan JY,Han JY

    更新日期:2019-08-01 00:00:00

  • Circadian clock: Time for novel anticancer strategies?

    abstract::Disruption of the circadian clock is associated with a variety of human pathologies, including cancer. Rather than being a mere consequence of a global changes associated with the cancer cell transcriptome, the aberrant clock gene expression observed in many tumors may serve for cancer cell survival. This scenario sug...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ercolani L,Ferrari A,De Mei C,Parodi C,Wade M,Grimaldi B

    更新日期:2015-10-01 00:00:00

  • Clinical effectiveness of zinc supplementation on the biomarkers of oxidative stress: A systematic review and meta-analysis of randomized controlled trials.

    abstract:BACKGROUND:Oxidative stress plays an important role in the occurrence of chronic diseases. Zinc supplementation is also known to be an antioxidant agent. While, there is no review on the effects of zinc supplementation on oxidative stress, this study aimed to systematically summarize randomized clinical trials (RCTs) w...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Mousavi SM,Hajishafiee M,Clark CCT,Borges do Nascimento IJ,Milajerdi A,Amini MR,Esmaillzadeh A

    更新日期:2020-11-01 00:00:00

  • Therapeutics in pediatric diabetes: insulin and non-insulin approaches. Part of a series on Pediatric Pharmacology, guest edited by Gianvincenzo Zuccotti, Emilio Clementi, and Massimo Molteni.

    abstract::Treatment of pediatric diabetes can be challenging. Strict glucose control can be accompanied by hypoglycemia and weight gain. Recently, there have been many developments in insulin preparations and delivery methods which make insulin levels more close to a physiologic pattern. Newly developed rapid/long acting analog...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kim J,Kim SM,Nguyen HC,Redondo MJ

    更新日期:2012-01-01 00:00:00

  • Modulation of inflammatory paw oedema by cysteamine in the rat.

    abstract::Cysteamine, a potent somatostatin depletor, was used in the present study to investigate the role of endogenous somatostatin in acute peripheral inflammation. The acute inflammation was induced by intraplantar injection of carrageenan (1%), histamine (5 micromol), or formalin (2.5%) in the rat hind paw. The induced in...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Salam OM

    更新日期:2002-04-01 00:00:00

  • The hamster heart: a paradox in itself.

    abstract::Perfusion of all mammalian heart muscle except hamster with Ca(2+)-free Tyrode and thereafter reperfusion with normal Tyrode causes irreversible damage, the calcium paradox. Our study aims at deciphering the role of creatine kinase, high energy phosphates and Ca(2+)influx in the genesis of myocardial injury in the rat...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ray M,Roy R,Chowdhury PD,Srivastava S,Dubey MP

    更新日期:2000-03-01 00:00:00

  • The effect of fluvoxamine on ouabain-induced arrhythmia in isolated guinea-pig atria.

    abstract::The effect of fluvoxamine (FLV) a selective serotonin reuptake inhibitor agent was studied on ouabain-induced arrhythmia in spontaneously beating isolated guinea-pig atria. FLV (8-64 microM) caused a dose-dependent decrease in the rate of contractions (7-52%) and in the contractile force (11-57%). Ouabain alone (2 mic...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pousti A,Deemyad T,Brumand K,Bakhtiarian A

    更新日期:2005-08-01 00:00:00

  • Neuropsychiatric reactions to drugs: an analysis of spontaneous reports from general practitioners in Italy.

    abstract::Limited information is available on drug-induced neuropsychiatric disorders in general practice. The spontaneous reports of both neurological and psychiatric adverse drug reactions (ADRs) collected during a 2-year period in PharmaSearch database, an Italian database recording reports of ADRs from general practitioners...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Galatti L,Giustini SE,Sessa A,Polimeni G,Salvo F,Spina E,Caputi AP

    更新日期:2005-03-01 00:00:00

  • Investigation of cancer drug resistance mechanisms by phosphoproteomics.

    abstract::Cancer cell mutations can be identified by genomic and transcriptomic techniques. However, they are not sufficient to understand the full complexity of cancer heterogeneity. Analyses of proteins expressed in cancers and their modification profiles show how these mutations could be translated at the functional level. P...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Boulos JC,Yousof Idres MR,Efferth T

    更新日期:2020-10-01 00:00:00

  • Inhibition of poly(ADP-ribose) polymerase attenuates lung tissue damage after hind limb ischemia-reperfusion in rats.

    abstract::The objective of this study was to investigate the effects of 3-aminobenzamide (3-AB) on tissue damage in lung after hind limb ischemia-reperfusion (I/R), by assessing blood biochemical assay and histopathological analysis. Thirty-five adult Wistar rats were divided into five groups. After application of anaesthesia b...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Koksel O,Yildirim C,Cinel L,Tamer L,Ozdulger A,Bastürk M,Degirmenci U,Kanik A,Cinel I

    更新日期:2005-05-01 00:00:00

  • Statins in chronic kidney disease and kidney transplantation.

    abstract::HMG-CoA reductase inhibitors (statins) have been shown to improve cardiovascular (CV) outcomes in the general population as well as in patients with cardiovascular disease (CVD). Statins' beneficial effects have been attributed to both cholesterol-lowering and cholesterol-independent "pleiotropic" properties. By their...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kassimatis TI,Goldsmith DJ

    更新日期:2014-10-01 00:00:00

  • Versatile antitumor potential of isoxanthohumol: Enhancement of paclitaxel activity in vivo.

    abstract::Isoxanthohumol (IXN), a prenylated flavonoid from hops, exhibits diverse biological activities, e.g. antitumor, antiinflammatory, antioxidant and antiangiogenic. In this study, the effect of IXN is evaluated on two melanoma cell lines with dissimilar molecular background, B16 and A375. The treatment of both cell lines...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Krajnović T,Kaluđerović GN,Wessjohann LA,Mijatović S,Maksimović-Ivanić D

    更新日期:2016-03-01 00:00:00

  • Piezo2 channel in nodose ganglia neurons is essential in controlling hypertension in a pathway regulated directly by Nedd4-2.

    abstract::Baroreflex plays a crucial role in regulation of arterial blood pressure (BP). Recently, Piezo1 and Piezo2, the mechanically-activated (MA) ion channels, have been identified as baroreceptors. However, the underlying molecular mechanism for regulating these baroreceptors in hypertension remains unknown. In this study,...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Huo L,Gao Y,Zhang D,Wang S,Han Y,Men H,Yang Z,Qin X,Wang R,Kong D,Bai H,Zhang H,Zhang W,Jia Z

    更新日期:2020-12-19 00:00:00

  • Clinical pharmacokinetic registration file for NDA and ANDA procedures.

    abstract::Pharmacokinetics is a relatively young branch of the life sciences, which has developed rapidly in the last 15-20 years, thanks to a series of analytical achievements that have allowed drug concentrations to be measured in biological matrices with highly selective and sensitive methods. Most old drugs and all new drug...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Marzo A

    更新日期:1997-12-01 00:00:00

  • Haemodynamic effects of nisoldipine by oral route.

    abstract::The aim of this study is to investigate the acute haemodynamic effect of orally administered nisoldipine. Eight patients with stable angina and normal overall ventricular function were submitted to cardiac catheterization and angiography before and one hour after administration of nisoldipine 20 mg per os. Cardiac out...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Razzolini R,Boffa GM,Calvanese A,Isabella G,Ramondo A,Chioin R

    更新日期:1991-10-01 00:00:00

  • Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart.

    abstract::Capsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Oroszi G,Szilvassy Z,Nemeth J,Tosaki A,Szolcsanyi J

    更新日期:1999-08-01 00:00:00

  • Blockade of the p38 mitogen-activated protein kinase pathway inhibits inducible nitric oxide synthase and interleukin-6 expression in MC3T3E-1 osteoblasts.

    abstract::Treatment of MC3T3E-1 osteoblast cultures with combined interferon- gamma(IFN- gamma), lipopolysaccharide (LPS) and tumor necrosis factor- alpha(TNF- alpha) induces expressions of inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6), resulting in sustained releases of large amounts of nitric oxide and IL-6....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Chae HJ,Kim SC,Chae SW,An NH,Kim HH,Lee ZH,Kim HR

    更新日期:2001-03-01 00:00:00

  • Pharmacological postconditioning against myocardial infarction with a slow-releasing hydrogen sulfide donor, GYY4137.

    abstract::Exogenous hydrogen sulfide (H2S) protects against myocardial ischemia/reperfusion injury but the mechanism of action is unclear. The present study investigated the effect of GYY4137, a slow-releasing H2S donor, on myocardial infarction given specifically at reperfusion and the signalling pathway involved. Thiobutabarb...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Karwi QG,Whiteman M,Wood ME,Torregrossa R,Baxter GF

    更新日期:2016-09-01 00:00:00

  • Influence of 3-PPP, a sigma receptor ligand, on the anticonvulsive action of conventional antiepileptic drugs.

    abstract::(+)-3-(3-Hydroxyphenyl)-N-(1-propyl)-piperidine (3-PPP; a sigma receptor ligand), administered at 30 mg kg-1, 30 min before the test, significantly decreased the electroconvulsive threshold in mice, being ineffective in lower doses. 3-PPP (20 mg kg-1) diminished the protective activity of diphenylhydantoin, phenobarbi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Borowicz KK,Kleinrok Z,Czuczwar SJ

    更新日期:1999-12-01 00:00:00

  • Pharmacological studies of cardamom oil in animals.

    abstract::Cardamom seeds are widely used for flavouring purposes in food and as carminative. Little information has been reported on their pharmacological and toxicological properties or, for their volatile oil which constitutes about 5% of the seed's total weight. A comparative study of the anti-inflammatory activity of the oi...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: al-Zuhair H,el-Sayeh B,Ameen HA,al-Shoora H

    更新日期:1996-07-01 00:00:00

  • Cholinesterase inhibitors: new roles and therapeutic alternatives.

    abstract::An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Giacobini E

    更新日期:2004-10-01 00:00:00

  • Endothelium-dependent mechanisms of the vasodilatory effect of the endocannabinoid, anandamide, in the rat pulmonary artery.

    abstract::Endocannabinoids exhibit vasodilatory properties and reduce blood pressure in vivo. However, the influence and mechanism of action of the prominent endocannabinoid, anandamide (AEA), in pulmonary arteries are not known. The present study determined the vascular response to AEA in isolated rat pulmonary arteries. AEA r...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Baranowska-Kuczko M,MacLean MR,Kozłowska H,Malinowska B

    更新日期:2012-09-01 00:00:00

  • NGF topical application in patients with corneal ulcer does not generate circulating NGF antibodies.

    abstract::Nerve growth factor (NGF) is the prototype of the neurotrophin family and promotes the survival of specific populations of neurons, stimulates their morphological differentiation and regulates neuronal gene expression. Since its discovery, NGF attracted clinicians for its potential application in the treatment of neur...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Lambiase A,Coassin M,Sposato V,Micera A,Sacchetti M,Bonini S,Aloe L

    更新日期:2007-07-01 00:00:00

  • Effects of curcumin on HDL functionality.

    abstract::Curcumin, a bioactive polyphenol, is a yellow pigment of the Curcuma longa (turmeric) plant. Curcumin has many pharmacologic effects including antioxidant, anti-carcinogenic, anti-obesity, anti-angiogenic and anti-inflammatory properties. Recently, it has been found that curcumin affects lipid metabolism, and subseque...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ganjali S,Blesso CN,Banach M,Pirro M,Majeed M,Sahebkar A

    更新日期:2017-05-01 00:00:00

  • Drugs preventing Na+ and Ca2+ overload.

    abstract::Cardiac intracellular Na+and Ca2+homeostasis is regulated by the concerted action of ion channels, pumps and exchangers. The Na+, K+-ATPase produces the electrochemical concentration gradient for Na+, which is the driving force for Ca2+removal from the cytosol via the Na+/Ca2+exchange. Reduction of this gradient by in...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Ravens U,Himmel HM

    更新日期:1999-03-01 00:00:00

  • Diabetes differentially modulated receptor- and non-receptor-mediated relaxation in rat renal artery.

    abstract::In this study, we have investigated the vasodilator response to acetylcholine under diabetic conditions in isolated renal arteries of Wistar rats. The effect of nitric oxide synthase (NOS) inhibition on acetylcholine-induced vasodilator response was investigated. We have also examined the effects of two endothelium-de...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Yousif MH

    更新日期:2003-09-01 00:00:00

  • An in vitro study of inhibitory activity of gossypol, a cottonseed extract, in human carcinoma cell lines.

    abstract::Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety of cancer cell lines. The objective of this study was to determine the inhibitory effects of gossypol on cell proliferation. Five human carcinoma cell lines were evaluated including endometrial (RL95-2), ovarian (SKOV-3), me...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Le Blanc M,Russo J,Kudelka AP,Smith JA

    更新日期:2002-12-01 00:00:00

  • Paradoxical sleep deprivation in rats causes a selective reduction in the expression of type-2 metabotropic glutamate receptors in the hippocampus.

    abstract::Paradoxical sleep deprivation in rats is considered as an experimental animal model of mania endowed with face, construct, and pharmacological validity. We induced paradoxical sleep deprivation by placing rats onto a small platform surrounded by water. This procedure caused the animal to fall in the water at the onset...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Panaccione I,Iacovelli L,di Nuzzo L,Nardecchia F,Mauro G,Janiri D,De Blasi A,Sani G,Nicoletti F,Orlando R

    更新日期:2017-03-01 00:00:00

  • Oral hydroxysafflor yellow A reduces obesity in mice by modulating the gut microbiota and serum metabolism.

    abstract::Given the high and increasing prevalence of obesity, the safe and effective treatment of obesity would be beneficial. Here, we examined whether oral hydroxysafflor yellow A (HSYA), an active compound from the dried florets of Carthamus tinctorius L., can reduce high-fat (HF) diet-induced obesity in C57BL/6 J mice. Our...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Liu J,Yue S,Yang Z,Feng W,Meng X,Wang A,Peng C,Wang C,Yan D

    更新日期:2018-08-01 00:00:00

  • Melatonin supplementation in the management of obesity and obesity-associated disorders: A review of physiological mechanisms and clinical applications.

    abstract::Despite the evolving advances in clinical approaches to obesity and its inherent comorbidities, the therapeutic challenge persists. Among several pharmacological tools already investigated, recent studies suggest that melatonin supplementation could be an efficient therapeutic approach in the context of obesity. In th...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Genario R,Cipolla-Neto J,Bueno AA,Santos HO

    更新日期:2021-01-01 00:00:00