Antiretroviral drugs in HIV-infected children.

abstract：:Inflammation plays a key role in tumor promotion and development. Indeed, cyclooxygenase-2 (COX-2) expression is strongly associated with different types of cancer. An emerging class of compounds with significant anti-inflammatory properties is the hydrogen sulfide-releasing non-steroidal anti-inflammatory drugs (H2S-...

journal_title：Pharmacological research

authors： De Cicco P,Panza E,Ercolano G,Armogida C,Sessa G,Pirozzi G,Cirino G,Wallace JL,Ianaro A

更新日期：2016-12-01 00:00:00

abstract：:The effect of the inhalation of vaporized ethanol on injected [1-14C]pyruvate kinetics was studied in mice. The [1-14C]pyruvate kinetics were modelled by means of a four-compartment closed model, i.e. injected site, blood, periphery and expired 14CO2. The results show that the inhalation of vaporized ethanol can stimu...

journal_title：Pharmacological research

authors： Wu G

更新日期：1998-01-01 00:00:00

abstract：:Injury to the bronchial epithelium in respiratory diseases such as asthma and COPD results in the loss of barrier function and an elevated sensitivity to environmental insults. An increased release of the endogenous cannabinoid, anandamide in response to inhalation of allergen in asthmatic patients has been reported. ...

journal_title：Pharmacological research

authors： Shang VC,O'Sullivan SE,Kendall DA,Roberts RE

更新日期：2016-03-01 00:00:00

abstract：:This review summarizes the metabolism, secretion, regulation and sites of action of melatonin. An updated description of the melatonin receptors, including their signal transduction mechanisms, distribution and characterization of receptor genes, is given. Special emphasis is focused on the clinical aspects and potent...

journal_title：Pharmacological research

authors： Carpentieri A,Díaz de Barboza G,Areco V,Peralta López M,Tolosa de Talamoni N

更新日期：2012-04-01 00:00:00

abstract：:The endogenous gasotransmitter hydrogen sulphide (H2S) is an important regulator of the cardiovascular system, particularly of myocardial function. Moreover, H2S exhibits cardioprotective activity against ischemia/reperfusion (I/R) or hypoxic injury, and is considered an important mediator of "ischemic preconditioning...

journal_title：Pharmacological research

authors： Testai L,Marino A,Piano I,Brancaleone V,Tomita K,Di Cesare Mannelli L,Martelli A,Citi V,Breschi MC,Levi R,Gargini C,Bucci M,Cirino G,Ghelardini C,Calderone V

更新日期：2016-11-01 00:00:00

abstract：:Breast cancer, the most prevalent cancer in women, remains the second in the list of cancer mortality, the majority of these fatalities resulted from estrogen receptor alpha (ERα) positive disease. ERα is well known for its function on breast cancer initiation and development and has become the most successful biomark...

journal_title：Pharmacological research

authors： Zhao Y,Zhao C,Lu J,Wu J,Li C,Hu Z,Tian W,Yang L,Xiang J,Zhou H,Deng Z,Huang J,Hong K

更新日期：2019-08-01 00:00:00

abstract：:It has been reported that patients with Hodgkin's disease (HD) show altered porphyrin metabolism, and suggested that the cause is the neoplastic process itself. If this is true, disease progression should be associated with higher levels of porphyrin excretion. The aim of this study was to evaluate urinary coproporphy...

journal_title：Pharmacological research

authors： Pinelli A,Mussini C,Buratti M,Parmiggiani-Venezia M,Trivulzio S

更新日期：2005-03-01 00:00:00

abstract：:Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder caused by an impaired receptor-mediated low-density lipoprotein (LDL) removal from the circulation, mainly due to disruptive autosomal co-dominant mutations in the LDL receptor (LDLr) gene, but also less frequently in the apolipoprotein B100 (...

journal_title：Pharmacological research

authors： Hajighasemi S,Mahdavi Gorabi A,Bianconi V,Pirro M,Banach M,Ahmadi Tafti H,Reiner Ž,Sahebkar A

更新日期：2019-05-01 00:00:00

abstract：:Diabetes mellitus is associated with both microvascular and macrovascular complications, which can result in visceral aneurysms as for example splenic artery aneurysms: in their management, an endovascular treatment, less invasive than surgery, is generally preferred. Endovascular treatment of splenic artery aneurysms...

journal_title：Pharmacological research

authors： Venturini M,Marra P,Colarieti A,Agostini G,Lanza C,Augello L,Gusmini S,Salvioni M,Melissano G,Fiorina P,Chiesa R,De Cobelli F,Del Maschio A

更新日期：2018-09-01 00:00:00

abstract：:The gastrointestinal effects of single and repeated administration of ferrous sulphate was evaluated measuring faecal flora modifications and histology of stomach and duodenum of the rat. The acute experiments showed reversible histopathological lesions of stomach and duodenum with iron deposition and increase in faec...

journal_title：Pharmacological research

authors： Benoni G,Cuzzolin L,Zambreri D,Donini M,Del Soldato P,Caramazza I

更新日期：1993-01-01 00:00:00

abstract：:DB-67 and its lactone homolog DB-91 are derivatives of topoisomerase I inhibitor camptothecin (CPT) with silyl moiety, which may exhibit a slower inactivation process by changed kinetics of protein binding and/or hydrolysis of its lactone ring and result in increased antitumor activity and decreased toxicity. Pharmaco...

journal_title：Pharmacological research

authors： Yeh TK,Li CM,Chen CP,Chuu JJ,Huang CL,Wang HS,Shen CC,Lee TY,Chang CY,Chang CM,Chao YS,Lin CT,Chang JY,Chen CT

更新日期：2010-02-01 00:00:00

abstract：:The purpose of the present work was to study the change in morphine metabolic ratio in obese subjects before and after Roux-en-Y Gastric Bypass (RYGB) and to identify clinical and/or biological factors associated with this change. The pharmacokinetics (PK) of oral morphine (30mg), morphine-3-glucuronide (M3G) and morp...

journal_title：Pharmacological research

authors： Lloret-Linares C,Luo H,Rouquette A,Labat L,Poitou C,Tordjman J,Bouillot JL,Mouly S,Scherrmann JM,Bergmann JF,Declèves X

更新日期：2017-04-01 00:00:00

abstract：:Several studies on disease and treatment effects on neurohormones have been conducted with small numbers of patients, using one blood sample as representative of their states. The aim of this study was to assess the within-patient variability of plasma concentrations of several hormones and cytokines of recent interes...

journal_title：Pharmacological research

authors： Masson S,Latini R,Bevilacqua M,Vago T,Sessa F,Torri M,Anesini A,Salio M,Pasotti E,Agnello D,Santoro L,Catania A,Ghezzi P,Moccetti T,Maggioni AP

更新日期：1998-03-01 00:00:00

abstract：:When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influen...

journal_title：Pharmacological research

authors： Ferland DJ,Watts SW

更新日期：2015-09-01 00:00:00

abstract：:Leukocyte arylsulphatase A (AS-A) was shown to be significantly high in newly-diagnosed breast cancer patients. Previous reports imply a connection between serum interleukin-6 (IL-6) and breast cancer, possibly through a modulation of enzymes involved in estrogen synthesis. Abnormal distribution of heparan sulphate pr...

journal_title：Pharmacological research

authors： Oner-Iyidoğan Y,Oner P,Koçak H,Lama A,Gürdöl F,Bekpinar S,Unur N,Ozbek-Kir Z

更新日期：2005-10-01 00:00:00

abstract：:Nephrotoxicity associated with cyclosporine A (CsA) administration is characterized by marked renal vasoconstriction, interstitial fibrosis and arteriolar hypertrophy. The molecular mechanisms of CsA nephrotoxicity are not well characterized, but previous studies have demonstrated that angiotensin II (Ang II), the pri...

journal_title：Pharmacological research

authors： Padi SS,Chopra K

更新日期：2002-05-01 00:00:00

abstract：:Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety of cancer cell lines. The objective of this study was to determine the inhibitory effects of gossypol on cell proliferation. Five human carcinoma cell lines were evaluated including endometrial (RL95-2), ovarian (SKOV-3), me...

journal_title：Pharmacological research

authors： Le Blanc M,Russo J,Kudelka AP,Smith JA

更新日期：2002-12-01 00:00:00

abstract：:In spite of continuous research in the field of bronchial asthma, still no satisfactory drug is available. Recently a new class of oligopeptide exhibited antiallergic activity by inhibiting the synthesis of IgE antibody. The analogue of ADSDGK (94-335) has shown antiallergic activity in experimental models. The 94-335...

journal_title：Pharmacological research

authors： Singh R,Nath A,Gupta PP,Shulka M,Khare SK,Kundu B

更新日期：1998-05-01 00:00:00

abstract：:In the present study we evaluated the protective activity of pyridoxol L,2-pyrrolidon-5 carboxylate (metadoxine) against CCl4 intoxication in rats, especially in relation to liver fibrosis. After 6 consecutive weeks of CCl4 treatment, the animals developed liver fibrosis and inflammation as revealed by histological an...

journal_title：Pharmacological research

authors： Annoni G,Contu L,Tronci MA,Caputo A,Arosio B

更新日期：1992-01-01 00:00:00

abstract：:Asthma and COPD make up the majority of obstructive airways diseases (OADs), which affects ∼11 % of the population. The main drugs used to treat OADs have not changed in the past five decades, with advancements mainly comprising variations on existing treatments. The recent biologics are beneficial to only specific su...

journal_title：Pharmacological research

authors： Chapman DG,King GG,Robinson PD,Farah CS,Thamrin C

更新日期：2020-09-01 00:00:00

abstract：:The DNA microarrays have proven to be a state of the art technique for high throughput comprehensive analysis of thousand of genes in parallel. The application of a DNA microarray to compare normal and pathological cells, tissues or organs may allow, along with classical positional cloning techniques, to speed up the ...

journal_title：Pharmacological research

authors： Meloni R,Khalfallah O,Biguet NF

更新日期：2004-04-01 00:00:00

abstract：:Some macrolide antibiotics have been shown to produce significant drug-drug interactions through the inhibition of cytochrome P450 (CYP) enzymes. In renal transplant patients these interactions pose potentially serious problems for the safe administration of cyclosporine A (CSA), a substrate of CYP3A4. The effects of ...

journal_title：Pharmacological research

authors： Bachmann K,Jauregui L,Chandra R,Thakker K

更新日期：2003-06-01 00:00:00

abstract：:In this lipopolysaccharide (LPS)-induced endotoxemia model, the effects of 3-aminobenzamide (3-AB), a poly(ADP-ribose) synthetase (PARS) inhibitor, on ileal apoptosis were evaluated by light microscopy and M30 cell death staining. Moreover, the relationship between Bcl-2, iNOS expression, and serum nitrate (NO(3)(-)) ...

journal_title：Pharmacological research

authors： Cinel I,Buyukafsar K,Cinel L,Polat A,Atici S,Tamer L,Oral U

更新日期：2002-08-01 00:00:00

abstract：:Thioredoxin is one of the most important cellular antioxidant systems known to date, and is responsible of maintaining the reduced state of the intracellular space. Trx-1 is a small cytosolic protein whose transcription is induced by stress. Therefore it is possible that this antioxidant plays a protective role agains...

journal_title：Pharmacological research

authors： D'Annunzio V,Perez V,Boveris A,Gelpi RJ,Poderoso JJ

更新日期：2016-07-01 00:00:00

abstract：:We studied here the effect of a wide range of adenosine concentration and time of preincubation, on the histamine release induced in the guinea pig mast cells by different stimulus. Adenosine (10(-5)-10(-3)m) potentiated the histamine release induced by antigen in the guinea pig heart (isolated and dispersed tissue) a...

journal_title：Pharmacological research

authors： Campos BG,Ferreira RR,Gomes JC

更新日期：2000-03-01 00:00:00

abstract：:In recent years, natural products have reemerged as biotherapeutic options, with several dietary carotenoids, viz. astaxanthin, fucoxanthin, siphonaxanthin, β-cryptoxanthin, α-carotene, β-carotene, and lycopene, developing as potential candidates for chemoprevention and chemotherapeutics of breast, colorectal, lung, a...

journal_title：Pharmacological research

authors： Saini RK,Keum YS,Daglia M,Rengasamy KR

更新日期：2020-07-01 00:00:00

abstract：:Mammals and their intestinal microbiota peacefully coexist in a mutualistic relationship. Commensal bacteria play an active role in shaping and modulating physiological processes in the host, which include, but are not restricted to, the immune system and the intestinal barrier. Both play a crucial role in containing ...

journal_title：Pharmacological research

authors： Natividad JM,Verdu EF

更新日期：2013-03-01 00:00:00

abstract：:Monoamine oxidases (MAO) are mitochondrial enzymes that catalyze the oxidation of monoamines in multiple tissues, including the brain. Elevated MAO activity has long been implicated in the etiology of depression, anxiety, and neurodegenerative disease, fuelling the search for inhibitors in the prevention and treatment...

journal_title：Pharmacological research

authors： Dreiseitel A,Korte G,Schreier P,Oehme A,Locher S,Domani M,Hajak G,Sand PG

更新日期：2009-05-01 00:00:00

abstract：:A favourable option to management symptoms during menopausal transition is menopausal hormone therapy (MHT) but relation among MHT and risk of melanoma is controversial. This study aims to identify, analyse and present the evidence surrounding post-menopausal exogenous hormone therapy and the risk for melanoma in wome...

journal_title：Pharmacological research

authors： Tang X,Zhang H,Cui Y,Wang L,Wang Z,Zhang Y,Huo J,Cai J,Rinaldi G,Bhagavathula AS,Xiaopeng Y

更新日期：2020-10-01 00:00:00

abstract：:In the past two decades, significant advances have been made in the etiology of lipid disorders. Concomitantly, the discovery of liporegulatory functions of certain short-chain fatty acids has generated interest in their clinical applications. In particular, butyric acid (BA) and its derivative, 4-phenylbutyric acid (...

journal_title：Pharmacological research

authors： He B,Moreau R

更新日期：2019-06-01 00:00:00