Abstract：
:When chemerin was discovered in 1997, it was relegated to being a protein associated with the normal skin function contrasting the setting of psoriasis. However, with the discovery of multiple receptors for the chemerin protein and a vast collection of associations with various pathologies, chemerin has global influence capable of regulating chemotactic, adipokine, autocrine/paracrine, adipogenic, angiogenic, and reproductive functions. These individual abilities of chemerin are important for understanding its basic pharmacology and physiology, but application of these principles to human pathology relies on the ability of scientists and physicians to view this protein from a much wider, all-encompassing angle. A global participant in the action of chemerin is the cardiovascular system (CVS). Although the CVS may not have as many direct interactions (e.g. smooth muscle in endothelium) with chemerin as it does indirect (e.g. chemerin activation in the lumen by proteases), our basic understanding of the CVS and its relation to chemerin is necessary to form a proper grasp of its individual actions and make the applications to pathology. This review provides a fundamental, yet comprehensive review of chemerin that inherently identifies the CVS as a necessary link between chemerin and its associated pathologies, but also calls for basic cardiovascular research as the solution to this chasm between knowledge and application.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Ferland DJ,Watts SWdoi
10.1016/j.phrs.2015.07.018subject
Has Abstractpub_date
2015-09-01 00:00:00pages
351-61eissn
1043-6618issn
1096-1186pii
S1043-6618(15)00151-6journal_volume
99pub_type
杂志文章,评审abstract：:TNF-related apoptosis-inducing ligand (TRAIL) selectively induces the apoptosis pathway in tumor cells leading to tumor cell death. Because TRAIL induction can kill tumor cells, cancer researchers have developed many agents to target TRAIL and some of these agents have entered clinical trials in oncology. Unfortunatel...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
doi：10.1016/j.phrs.2020.104716
更新日期：2020-05-01 00:00:00
abstract：:The present investigation was undertaken to suggest the involvement of free radicals in the pathogenesis of pyloric ligation induced ulcers in rats. Lipid peroxidation product (MDA), antioxidant contents and secretory activity have been studied in the rat stomach at different time intervals after pylorus ligation indu...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1006/phrs.1998.0343
更新日期：1998-08-01 00:00:00
abstract：:Photodynamic therapy (PDT) using 5-aminolevulinic acid (ALA)-induced protoporphyrin IX may play a role in the treatment of dysplastic Barrett's oesophagus. An ALA thermosetting gel Pluronic F-127) was developed and evaluated in an in vivo mouse model for potential use in PDT of Barrett's mucosa. In vitro studies of th...
journal_title：Pharmacological research
pub_type： 杂志文章
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abstract：:Gossypol, a cottonseed extract, has been shown to have antiproliferative activity in a variety of cancer cell lines. The objective of this study was to determine the inhibitory effects of gossypol on cell proliferation. Five human carcinoma cell lines were evaluated including endometrial (RL95-2), ovarian (SKOV-3), me...
journal_title：Pharmacological research
pub_type： 杂志文章
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journal_title：Pharmacological research
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更新日期：2016-11-01 00:00:00
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journal_title：Pharmacological research
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doi：10.1016/j.phrs.2012.02.012
更新日期：2012-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2000-01-01 00:00:00
abstract：:Leishmaniases are severe vector-borne diseases affecting humans and animals, caused by Leishmania protozoans. Over one billion people and millions of dogs live in endemic areas for leishmaniases and are at risk of infection. Immune polarization plays a major role in determining the outcome of Leishmania infections: ho...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2020-11-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2013.06.009
更新日期：2013-10-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2012-06-01 00:00:00
abstract：:The gut microbiota and its short chain fatty acid (SCFA) metabolites have been established to play an important protective role against neurodegenerative diseases. Our previous study demonstrated that cerebral ischemic stroke triggers dysfunctional gut microbiota and increased intestinal permeability. In this study, w...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2019.104403
更新日期：2019-10-01 00:00:00
abstract：:The Janus kinase (JAK) family of non-receptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (tyrosine kinase-2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that regulates the adjacent protein kinase domain (JH1). JAK1/2 and TYK2 are ubiquitously expressed whereas JAK3 is...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2016-09-01 00:00:00
abstract：:As the body's first line of defense, the skin is the organ most frequently exposed to chemicals present in personal hygiene products, household products, or materials used in the work environment. In this context, skin disorders account for more than 40 % of all occupational and work-related diseases, constituting a s...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2020.105282
更新日期：2020-12-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2019.104273
更新日期：2019-08-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/s1043-6618(03)00045-8
更新日期：2003-06-01 00:00:00
abstract：:Plasma lipid and lipoprotein levels were evaluated in 27 adults with essential hypertension at four different periods during a 12-month treatment with doxazosin. Mean plasma total cholesterol (TC), low-density lipoprotein-cholesterol (LDLC), triglyceride (TG), very low density lipoprotein-cholesterol (VLDLC) and the L...
journal_title：Pharmacological research
pub_type： 临床试验,杂志文章
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更新日期：1994-10-01 00:00:00
abstract：:An important aspect of brain cholinesterase function is related to enzymatic differences. The brain of mammals contains two major forms of cholinesterases: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The two forms differ genetically, structurally and for their kinetics. Butyrylcholine is not a physi...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2004-10-01 00:00:00
abstract：:A bovine dopamine transporter (bDAT) cDNA was transfected into CV-1 cells, a cell line that lacks vesicular storage and release mechanisms. Using this cell line, the effects of neuroleptic drugs on DAT-mediated uptake and release of dopamine (DA) were examined. All of the neuroleptic drugs tested, inhibited DA uptakes...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：
更新日期：1997-05-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2000-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：1998-04-01 00:00:00
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journal_title：Pharmacological research
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更新日期：2016-09-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2019-04-01 00:00:00
abstract：:A simple method for solubilization and reconstitution of the A1 adenosine receptor from bovine brain is presented. Solubilization with CHAPS-phosphatidylcholine (CHAPS/PC) mixture did not alter the binding properties of the A1 adenosine receptor antagonist [3H]-DPCPX. The solubilized receptors were chromatographed on ...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：1991-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/1043-6618(90)90727-u
更新日期：1990-05-01 00:00:00
abstract：:The understanding of signaling cascades involved in the induction, promotion, and progression of cancer, although advanced in recent years, is still incomplete. Tracing the imbalance of the impaired, physiologically-essential cellular signaling that drives the neoplastic process is a complex issue. This review discuss...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2012-07-01 00:00:00
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journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2017-11-01 00:00:00
abstract：:The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart and kidney homeostasis, but also plays an important role in the pathophysiology of heart and kidney diseases. Recently, new components of the RAS have been discovered, including angiotensin converting enzyme 2 (ACE2), Angiotensin(Ang)-(1-...
journal_title：Pharmacological research
pub_type： 杂志文章,评审
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更新日期：2016-05-01 00:00:00
abstract：:Erectile function is a widely accepted indicator of systemic endothelial activity since from a clinical standpoint erectile dysfunction (ED) often precedes cardiovascular events. Recently it has been described a potential role for β3 adrenoceptor in cardiovascular diseases emphasizing a possible development of new dru...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2017-10-01 00:00:00
abstract：:The pharmacokinetics of single intravenous and intramuscular administrations and milk antimicrobial equivalent activity of enrofloxacin at a dose of 5 mg per kilogram body weight were studied in clinically healthy lactating goats which were either not treated or had received 7.5 mg per kilogram body weight of albendaz...
journal_title：Pharmacological research
pub_type： 杂志文章
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更新日期：2003-10-01 00:00:00
abstract：:The effect of age and sex on the predictive value of colorectal cancer (CRC) patients treated with immune checkpoint inhibitors (ICIs) has been controversial, and the effect of specific gene mutations on the predictive value of CRC patients treated with ICIs remains to be explored. Our study analyzed the influence of ...
journal_title：Pharmacological research
pub_type： 杂志文章
doi：10.1016/j.phrs.2020.105028
更新日期：2020-09-01 00:00:00
