High urinary levels of resveratrol metabolites are associated with a reduction in the prevalence of cardiovascular risk factors in high-risk patients.


:Moderate wine consumption has been shown to reduce cardiovascular (CV) risk, due to alcohol and polyphenolic compounds, such as resveratrol. We investigated the associations between total urinary resveratrol metabolites (TRMs) as biomarkers of wine and resveratrol consumption and CV risk factors in a large cross-sectional study including high CV risk individuals in Spain. We studied 1000 participants in the PREDIMED Study in whom TRMs were analyzed by LC-MS/MS with a previous solid phase extraction. Multiple linear regression of TRMs (biomarker of wine consumption) improved the mean (95% CI) of HDL [0.168 (0.027-0.309); P=0.02] and triglyceride [-1.012 (-1.797 to -0.227); P=0.012] plasma concentrations and heart rate [-0.259 (-0.412 to -0.107); P<0.001]. Models of TRMs adjusted for alcohol (biomarker of resveratrol intake) decreased fasting blood glucose [-0.533 (-1.034 to -0.033); P=0.037] and triglyceride [-1.014 (-1.998 to -0.029); P=0.044] concentrations, and heart rate [-0.277 (-0.467 to -0.087); P=0.004]. Both resveratrol and wine intake, evaluated as TRMs, were associated with beneficial changes in blood lipid profiles, fasting blood glucose (only resveratrol) and heart rate, suggesting that resveratrol intake via wine consumption might help to decrease CV risk factors.


Pharmacol Res


Pharmacological research


Zamora-Ros R,Urpi-Sarda M,Lamuela-Raventós RM,Martínez-González MÁ,Salas-Salvadó J,Arós F,Fitó M,Lapetra J,Estruch R,Andres-Lacueva C,PREDIMED Study Investigators.




Has Abstract


2012-06-01 00:00:00














  • Effects of genetic polymorphisms on the pharmacokinetics and pharmacodynamics of proton pump inhibitors.

    abstract::Proton pump inhibitors (PPIs) are used widely for the treatment of acid-related disorders. Despite their excellent efficacy and tolerance, the pharmacodynamics and pharmacokinetics of PPIs are affected by each patient's CYP2C19 and gastric H+,K+-ATPase genotype. The aim of this review was to analyze the effect of gene...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Zhang HJ,Zhang XH,Liu J,Sun LN,Shen YW,Zhou C,Zhang HW,Xie LJ,Chen J,Liu Y,Wang YQ

    更新日期:2020-02-01 00:00:00

  • Meta-analysis on outcome-worsening comorbidities of COVID-19 and related potential drug-drug interactions.

    abstract::Drug-drug interactions (DDI) potentially occurring between medications used in the course of COVID-19 infection and medications prescribed for the management of underlying comorbidities may cause adverse drug reactions (ADRs) contributing to worsening of the clinical outcome in affected patients. First, we conducted a...

    journal_title:Pharmacological research

    pub_type: 杂志文章,meta分析


    authors: Awortwe C,Cascorbi I

    更新日期:2020-11-01 00:00:00

  • Gastric motor effects of triptans: open questions and future perspectives.

    abstract::Sumatriptan is a 5-HT1B/D receptor agonist of documented efficacy in relieving migraine and associated symptoms such as nausea and vomiting. In the past decade, several studies reported an important delay of gastric emptying induced by sumatriptan in healthy humans. The impact of this gastric motor effect of sumatript...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Cipolla G,Sacco S,Crema F,Moro E,De Ponti F,Frigo G

    更新日期:2001-03-01 00:00:00

  • Endocannabinoids and cardiac contractile function: pathophysiological implications.

    abstract::Endocannabinoids are part of a bioactive lipid signaling system, not only in the central nervous system but also in various peripheral organs. Accumulating evidence implicates dysregulation of the endocannabinoid system (ECS) in the pathogenesis of various cardiovascular diseases, including hypertension, atheroscleros...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Bátkai S,Pacher P

    更新日期:2009-08-01 00:00:00

  • Imiquimod-induced psoriasis-like skin inflammation is suppressed by BET bromodomain inhibitor in mice through RORC/IL-17A pathway modulation.

    abstract::Psoriasis is one of the most common skin disorders characterized by erythematous plaques that result from hyperproliferative keratinocytes and infiltration of inflammatory leukocytes into dermis and epidermis. Recent studies suggest that IL-23/IL-17A/IL-22 cytokine axis plays an important role in the pathogenesis of p...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Nadeem A,Al-Harbi NO,Al-Harbi MM,El-Sherbeeny AM,Ahmad SF,Siddiqui N,Ansari MA,Zoheir KM,Attia SM,Al-Hosaini KA,Al-Sharary SD

    更新日期:2015-09-01 00:00:00

  • Bleomycin in the setting of lung fibrosis induction: From biological mechanisms to counteractions.

    abstract::Bleomycin (BLM) is a drug used to treat different types of neoplasms. BLM's most severe adverse effect is lung toxicity, which induces remodeling of lung architecture and loss of pulmonary function, rapidly leading to death. While its clinical role as an anticancer agent is limited, its use in experimental settings is...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Della Latta V,Cecchettini A,Del Ry S,Morales MA

    更新日期:2015-07-01 00:00:00

  • Segetoside I, a plant-derived bisdesmosidic saponin, induces apoptosis in human hepatoma cells in vitro and inhibits tumor growth in vivo.

    abstract::Segetoside I is a plant-derived bisdesmosidic saponin from Vaccaria segetalis (Neck) with reported anticancer activities. This development has raised an interest in the therapeutic potential of segetoside I. Here, we report the in vitro and in vivo antitumor activities of segetoside I against some selected cancer cell...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Firempong CK,Zhang HY,Wang Y,Chen J,Cao X,Deng W,Zhou J,Wang Q,Tong SS,Yu J,Xu X

    更新日期:2016-08-01 00:00:00

  • Cinnamtannin D1 attenuates autoimmune arthritis by regulating the balance of Th17 and treg cells through inhibition of aryl hydrocarbon receptor expression.

    abstract::The suppression of the abnormal systemic immune response constitutes a primary strategy for treatment of rheumatoid arthritis (RA); toward this end, the identification of natural compounds with immunosuppressive activity represents a promising strategy for RA drug discovery. Cinnamtannin D1 (CTD-1), a polyphenolic com...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Shi C,Zhang H,Wang X,Jin B,Jia Q,Li Y,Yang Y

    更新日期:2020-01-01 00:00:00

  • Biosimilars in rheumatology.

    abstract::Biotechnologicals are an invaluable resource in the treatment of patients with inflammatory rheumatic diseases (IRD) non-responsive or intolerant to conventional therapies. However, they are the main driver for increase in direct costs and represent a significant economic burden to healthcare systems worldwide. Since ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Araújo FC,Gonçalves J,Fonseca JE

    更新日期:2019-11-01 00:00:00

  • QiShenYiQi Pills® ameliorates ischemia/reperfusion-induced myocardial fibrosis involving RP S19-mediated TGFβ1/Smads signaling pathway.

    abstract::QiShenYiQi Pills (QSYQ) is a compound Chinese medicine widely used in China for treatment of cardiovascular disease. However, limited data are available regarding the anti-fibrotic role of QSYQ after ischemia/reperfusion (I/R) injury. This study aimed to investigate the effect of post-treatment with QSYQ on myocardial...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zheng QN,Wei XH,Pan CS,Li Q,Liu YY,Fan JY,Han JY

    更新日期:2019-08-01 00:00:00

  • Delivery routes for faecal microbiota transplants: Available, anticipated and aspired.

    abstract::Fecal microbiota transplant (FMT) has seen a historic emergence in last decade with its sojourn recently entering into a chequered path, due to a few reports of infection and subsequent mortality. Though FMT has been extensively reported, there is no comprehensive report on the delivery routes available for this non-p...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Gulati M,Singh SK,Corrie L,Kaur IP,Chandwani L

    更新日期:2020-09-01 00:00:00

  • Eltanolone (5-beta-pregnanolone) does not trigger, and attenuates halothane triggering of, malignant hyperthermia in malignant hyperthermia susceptible swine.

    abstract::Eltanolone is the lipid emulsion formulation, for intravenous use, of the steroid anaesthetic 5-beta-pregnanolone. We have screened this agent in malignant hyperthermia susceptible (MHS) Landrace swine to assess its potential to trigger the Malignant Hyperthermia (MH) syndrome in MHS subjects or to influence halothane...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Harrison GG,Dyer RA,Llewellyn RL,James MF

    更新日期:1999-02-01 00:00:00

  • Study of the evolution of blood and striatal levels of methyldopa: a microdialysis study in sinaortic denervated rats.

    abstract::Pharmacokinetic of methyldopa (50 mg kg(-1)i.p.) was studied in anesthetized sham operated and sinoaortic denervated (SAD) rats by using the microdialysis technique. Vascular shunt probe was inserted into the carotid artery and concentric probe was placed in the striatum. Levels of methyldopa were measured by HPLC-EC....

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Opezzo JA,Höcht C,Taira CA,Bramuglia GF

    更新日期:2000-04-01 00:00:00

  • Urinary pharmacokinetics of betalains following consumption of red beet juice in healthy humans.

    abstract::The aim of the present pilot study was to characterise the renal elimination of betalains after consumption of red beet juice (RBJ). Six healthy, non-smoking female volunteers were given a single oral dose of either 500 mL of a commercial RBJ containing 362.7 mg of betalains and 500 mL of tap water, respectively, in a...

    journal_title:Pharmacological research

    pub_type: 临床试验,杂志文章


    authors: Frank T,Stintzing FC,Carle R,Bitsch I,Quaas D,Strass G,Bitsch R,Netzel M

    更新日期:2005-10-01 00:00:00

  • Dicaffeoylquinic acids alleviate memory loss via reduction of oxidative stress in stress-hormone-induced depressive mice.

    abstract::Chronic stress can lead to depression due to elevated levels of stress hormones such as glucocorticoid. This is accompanied by an increase in reactive oxygen species (ROS) levels in the brain, which can cause dendritic spine loss and atrophy in neurons, followed by memory loss. Dicaffeoylquinic acids (diCQAs) are natu...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Lim DW,Park J,Jung J,Kim SH,Um MY,Yoon M,Kim YT,Han D,Lee C,Lee J

    更新日期:2020-11-01 00:00:00

  • Transcriptome profiling of NIH3T3 cell lines expressing opsin and the P23H opsin mutant identifies candidate drugs for the treatment of retinitis pigmentosa.

    abstract::Mammalian cells are commonly employed in screening assays to identify active compounds that could potentially affect the progression of different human diseases including retinitis pigmentosa (RP), a class of inherited diseases causing retinal degeneration with compromised vision. Using transcriptome analysis, we comp...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Chen Y,Brooks MJ,Gieser L,Swaroop A,Palczewski K

    更新日期:2017-01-01 00:00:00

  • Dosing ribavirin in hepatitis E-infected solid organ transplant recipients.

    abstract::Hepatitis E virus (HEV) is the most common cause of viral hepatitis worldwide. Genotypes 1 and 2 (GT1 and GT2) are mainly present in developing countries, while GT3 and GT4 are prevalent in developed and high-income countries. In the majority of cases, HEV causes a self-limiting hepatitis. GT3 and GT4 can be responsib...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: De Winter BCM,Hesselink DA,Kamar N

    更新日期:2018-04-01 00:00:00

  • Vigabatrin does not affect the intestinal absorption of phenytoin in rat duodeno-jejunal loops in situ.

    abstract::The antiepileptic drug vigabatrin (GVG) is known to decrease significantly the serum concentration of concurrently administered phenytoin (PHT) in epileptic patients. To assess a possible mechanism for this interaction, the effect of GVG on the intestinal absorption of PHT was investigated by means of circulation expe...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Tonini M,Gatti G,Manzo L,Olibet G,Coccini T,Perucca E

    更新日期:1992-09-01 00:00:00

  • Strengths, weaknesses and future challenges of biosimilars' development. An opinion on how to improve the knowledge and use of biosimilars in clinical practice.

    abstract::Biosimilars started receiving the marketing authorization by European Medicine Agency since 2006. The development of biosimilars follows a well-defined step-wise approach, the so-called comparability exercise, which aims to compare non-clinical (mainly quality features and biological activity) and clinical (efficacy a...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Scavone C,Rafaniello C,Berrino L,Rossi F,Capuano A

    更新日期:2017-12-01 00:00:00

  • Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins.

    abstract::The concentration of five lipid-soluble antioxidants (gamma- and alpha-tocopherol, lycopene, beta-carotene and ubiquinol-10) was measured in plasma and very low-density, low-density and high-density lipoproteins (VLDL, LDL and HDL) isolated from young healthy normo- cholesterolemic subjects. Alpha-tocopherol was the e...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Perugini C,Bagnati M,Cau C,Bordone R,Zoppis E,Paffoni P,Re R,Albano E,Bellomo G

    更新日期:2000-01-01 00:00:00

  • Cinnamaldehyde mitigates placental vascular dysfunction of gestational diabetes and protects from the associated fetal hypoxia by modulating placental angiogenesis, metabolic activity and oxidative stress.

    abstract::Gestational diabetes mellitus (GDM) is a major pregnancy-related disorder with an increasing prevalence worldwide. GDM is associated with altered placental vascular functions and has severe consequences for fetal growth. There is no commonly accepted medication for GDM due to safety considerations. Actions of the curr...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Hosni A,El-Twab SA,Abdul-Hamid M,Prinsen E,AbdElgawad H,Abdel-Moneim A,Beemster GTS

    更新日期:2021-01-13 00:00:00

  • MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1.

    abstract::As one classic anticancer drug, clinical application of Doxorubicin (Dox) is limited due to its side effects. In our previous work, we have investigated the drug targets to treat Dox-induced cardiotoxicity, hepatotoxicity and nephrotoxicity. In this paper, the mechanisms and new drug-target associated with Dox-induced...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Zhao X,Jin Y,Li L,Xu L,Tang Z,Qi Y,Yin L,Peng J

    更新日期:2019-08-01 00:00:00

  • Bolus magnesium infusion in humans is associated with predominantly unfavourable changes in platelet aggregation and certain haemostatic factors.

    abstract:UNLABELLED:The purpose of this study was an attempt to extrapolate favorable observations on the effects of magnesium on platelets and haemostasis from animal models to humans. Intravenous magnesium in the treatment of acute myocardial infarction has been tested in several large clinical trials and remains controversia...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Serebruany VL,Herzog WR,Schlossberg ML,Gurbel PA

    更新日期:1997-07-01 00:00:00

  • Neurochemical studies with the anticonvulsant felbamate in mouse brain.

    abstract::Felbamate (FBM) is a relatively novel anticonvulsant agent which has been reported to exert its antiepileptic effects by blockade of the glycine recognition site on the N-methyl-D-aspartate subtype of glutamate receptor and potentiation at the gamma-aminobutyric acid (GABA) type A receptor. An increasing number of ant...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Fraser CM,Sills GJ,Forrest G,Thompson GG,Brodie MJ

    更新日期:1999-09-01 00:00:00

  • To fingolimod and beyond: The rich pipeline of drug candidates that target S1P signaling.

    abstract::Sphingosine 1-phosphate (S1P) is an extracellular lipid signaling molecule that acts as a selective, high-affinity ligand for a family of five G protein-coupled receptors. This signaling system was first identified twenty years ago, and has since been shown to regulate a diverse range of physiological processes and di...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Chew WS,Wang W,Herr DR

    更新日期:2016-11-01 00:00:00

  • Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).

    abstract::Insulin-like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9) have been proposed to be important mediators in cardioprotection. A large body of evidence indicates that insulin like growth factor-1 has pleotropic actions in the heart (i.e., contractility, metabolism, hypertrophy, autophagy, senescence and cell ...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Westermeier F,Bustamante M,Pavez M,García L,Chiong M,Ocaranza MP,Lavandero S

    更新日期:2015-11-01 00:00:00

  • The inhibition of platelet aggregation by activated macrophages is blocked by dexamethasone.

    abstract::The effect of dexamethasone on the ability of activated J774 macrophages to inhibit platelet aggregation was investigated. After 24h incubation with lipopolysaccharide and gamma-interferon, J774 cells generated large amounts of nitric oxide and inhibited platelet aggregation. Incubation of the cells with dexamethasone...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Pinto A,Carnuccio R,Sorrentino R,Di Rosa M

    更新日期:1993-02-01 00:00:00

  • Sphingolipids as therapeutics.

    abstract::The sphingolipid field has made significant strides over the past 10 years: from identifying metabolites of the sphingomyelin pathway as second messengers to discerning the molecular biology and biophysics of these lipid-derived second messengers. Building upon this vast basic science literature, scientists from multi...

    journal_title:Pharmacological research

    pub_type: 杂志文章,评审


    authors: Kester M,Kolesnick R

    更新日期:2003-05-01 00:00:00

  • Thiamin status in furosemide-treated rats.

    abstract::Rats were treated with furosemide at intraperitoneal doses of 10, 20, and 30 mg kg(-1)day(-1)for 21 days, and some indices of thiamin status (liver, blood and urine thiamin concentrations, erythrocyte transketolase (TK) activity, and thiamin pyrophosphate (TPP) effect, which refers to the increase in TK activity in a ...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Ali BH,Al-Qarawi AA

    更新日期:2000-07-01 00:00:00

  • Effect of praziquantel versus hycanthone on deoxyribonucleic acid content of hepatocytes in murine schistosomiasis mansoni.

    abstract::Cytophotometric measurement of the effect of praziquantel (500 mg/kg for 2 days) versus hycanthone (60 mg/kg for 3 days) on hepatocyte nuclear deoxyribonucleic acid (DNA) content was evaluated in Schistosoma mansoni infected mice. Drugs were given 8 weeks post-infection and repeated weekly for 4 weeks. DNA values of i...

    journal_title:Pharmacological research

    pub_type: 杂志文章


    authors: Botros SS

    更新日期:1990-03-01 00:00:00