Abstract：
:Cardiovascular diseases (CVD) are among the main causes of death globally and in this context hypertension represents one of the key risk factors for developing a CVD. It is well established that the peripheral renin-angiotensin system (RAS) plays an important role in regulating blood pressure (BP). All components of the classic RAS can also be found in the brain but, in contrast to the peripheral RAS, how the endogenous RAS is involved in modulating cardiovascular effects in the brain is not fully understood yet. It is a complex system that may work differently in diverse areas of the brain and is linked to the peripheral system by the circumventricular organs (CVO), which do not have a blood brain barrier (BBB). In this review, we focus on the brain angiotensin peptides, their interactions with each other, and the consequences in the central nervous system (CNS) concerning cardiovascular control. Additionally, we present potential drug targets in the brain RAS for the treatment of hypertension.
journal_name
Pharmacol Resjournal_title
Pharmacological researchauthors
Huber G,Schuster F,Raasch Wdoi
10.1016/j.phrs.2017.06.016subject
Has Abstractpub_date
2017-11-01 00:00:00pages
72-90issue
Pt Aeissn
1043-6618issn
1096-1186pii
S1043-6618(17)30514-5journal_volume
125pub_type
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